DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60A and CPN60B

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001320637.1	Gene:	CPN60B / 841996	AraportID:	AT1G55490	Length:	600	Species:	Arabidopsis thaliana

Alignment Length:	545	Identity:	256/545 - (46%)
Similarity:	363/545 - (66%)	Gaps:	9/545 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AKDVRF---GPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIELKD 84
            ||::.|   |..:|.:. .||:.|||.|.||:|||||||::|..:|||:|..||||||:.:||:|
plant    56 AKELHFNKDGTTIRRLQ-AGVNKLADLVGVTLGPKGRNVVLESKYGSPRIVNDGVTVAREVELED 119

  Fly    85 KFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPVEIRRGVMLAVETVKD 149
            ..:|||||||:..|..||:.|||||||:.|||:....||.:.::.|||||.|.||:....:.:..
plant   120 PVENIGAKLVRQAAAKTNDLAGDGTTTSVVLAQGFIAEGVKVVAAGANPVLITRGIEKTAKALVT 184

  Fly   150 NLKTMSRPVSTPEEIAQVATISANGDQAIGNLISEAMKKVGRDGVITVKDGKTLTDELEVIEGMK 214
            .||.||:.|. ..|:|.||.:||..:..|||:|:|||.||||.||:|:::||:..:.|.|:|||:
plant   185 ELKKMSKEVE-DSELADVAAVSAGNNDEIGNMIAEAMSKVGRKGVVTLEEGKSAENNLYVVEGMQ 248

  Fly   215 FDRGYISPYFINSSKGAKVEFQDALLLLSEKKISSVQSIIPALELANAQRKPLVIIAEDIDGEAL 279
            ||||||||||:..|:...|||.:..|||.:|||::.:.::..||.|.....|::||||||:.|||
plant   249 FDRGYISPYFVTDSEKMSVEFDNCKLLLVDKKITNARDLVGVLEDAIRGGYPILIIAEDIEQEAL 313

  Fly   280 STLVVNRLKIGLQVAAVKAPGFGDNRKSTLTDMAIASGGIVFGDDADLVKLEDVKVSDLGQVGEV 344
            :|||||:|:..|::||::|||||:.:...|.|:||.:|..|..::..| .|:......||...:|
plant   314 ATLVVNKLRGTLKIAALRAPGFGERKSQYLDDIAILTGATVIREEVGL-SLDKAGKEVLGNASKV 377

  Fly   345 VITKDDTLLLKGKGKKDDVLRRANQIKDQIEDTTSEYEKEKLQERLARLASGVALLRVGGSSEVE 409
            |:||:.:.::.....:|.|.:|..|||:.||....:||||||.||:|:|:.|||:::||..:|.|
plant   378 VLTKETSTIVGDGSTQDAVKKRVTQIKNLIEQAEQDYEKEKLNERIAKLSGGVAVIQVGAQTETE 442

  Fly   410 VNEKKDRVHDALNATRAAVEEGIVPGGGTALLRCIEKLEGVETT--NEDQKLGVEIVRRALRMPC 472
            :.|||.||.||||||:||||||||.|||..|||...|::.::.|  |:::|:|.:||:|||..|.
plant   443 LKEKKLRVEDALNATKAAVEEGIVVGGGCTLLRLASKVDAIKATLDNDEEKVGADIVKRALSYPL 507

  Fly   473 MTIAKNAGVDGAMVVAKV-ENQAGDYGYDALKGEYGNLIEKGIIDPTKVVRTAITDASGVASLLT 536
            ..|||||||:|::|..|| .|....:||:|..|:|.:|:..||||||||||..:..|:.||....
plant   508 KLIAKNAGVNGSVVSEKVLSNDNVKFGYNAATGKYEDLMAAGIIDPTKVVRCCLEHAASVAKTFL 572

  Fly   537 TAEAVVTEIPKEDGAPAMPGMGGMG 561
            .::.||.||.:.:..|....|...|
plant   573 MSDCVVVEIKEPEPVPVGNPMDNSG 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	253/531 (48%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	250/525 (48%)
CPN60B	NP_001320637.1	PLN03167	1..600	CDD:215611	256/545 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D415781at2759
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780