DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60A and Cpn60beta3

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001032083.1	Gene:	Cpn60beta3 / 835751	AraportID:	AT5G56500	Length:	597	Species:	Arabidopsis thaliana

Alignment Length:	572	Identity:	268/572 - (46%)
Similarity:	379/572 - (66%)	Gaps:	19/572 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VSLARSSISR--QLAMRG-------YAKDVRFGPEVRAM--MLQGVDVLADAVAVTMGPKGRNVI 59
            ||::.||..|  .:|.|.       .||.:.|..:..|:  :..||:.|||.|.||:|||||||:
plant    26 VSISSSSFGRTQSIAQRKARFPKIYAAKQLHFNKDGTAIKKLQAGVNKLADLVGVTLGPKGRNVV 90

  Fly    60 IEQSWGSPKITKDGVTVAKSIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGF 124
            :|..:|||:|..||||||:.:||:|..:|||||||:..|:.||:.|||||||:.|||:.:..||.
plant    91 LESKYGSPRIVNDGVTVAREVELEDPVENIGAKLVRQAASKTNDLAGDGTTTSVVLAQGLIAEGV 155

  Fly   125 EKISKGANPVEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQVATISANGDQAIGNLISEAMKKV 189
            :.::.|||||.|.||:....:.:...||.||:.|. ..|:|.||.:||..:..:||:|:|||.||
plant   156 KVVAAGANPVLITRGIEKTTKALVAELKKMSKEVE-DSELADVAAVSAGNNYEVGNMIAEAMAKV 219

  Fly   190 GRDGVITVKDGKTLTDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALLLLSEKKISSVQSII 254
            ||.||:|:::||:..:.|.|:|||:||||||||||:..|:....|:::..|.|.:|||::.:.||
plant   220 GRKGVVTLEEGKSAENSLYVVEGMQFDRGYISPYFVTDSEKMCAEYENCKLFLVDKKITNARDII 284

  Fly   255 PALELANAQRKPLVIIAEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKSTLTDMAIASGGI 319
            ..||.|.....||:||||||:.|.|:|||||:|:..::|||:||||||:.:...|.|:|..:|..
plant   285 SILEDAIKGGYPLLIIAEDIEQEPLATLVVNKLRGTIKVAALKAPGFGERKSQYLDDIAALTGAT 349

  Fly   320 VFGDDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKGKKDDVL-RRANQIKDQIEDTTSEYEK 383
            |..::..| :||.|....||..|:||:|||.|.:: |.|..::|: :|..|||:.||....:|||
plant   350 VIREEVGL-QLEKVGPEVLGNAGKVVLTKDTTTIV-GDGSTEEVVKKRVEQIKNLIEAAEQDYEK 412

  Fly   384 EKLQERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAVEEGIVPGGGTALLRCIEKLE 448
            |||.||:|:|:.|||:::||..:|.|:.|||.||.||||||:||||||||.|||..|||...|::
plant   413 EKLNERIAKLSGGVAVIQVGAQTETELKEKKLRVEDALNATKAAVEEGIVVGGGCTLLRLASKVD 477

  Fly   449 GVETT--NEDQKLGVEIVRRALRMPCMTIAKNAGVDGAMVVAKV-ENQAGDYGYDALKGEYGNLI 510
            .::.|  |:::|:|.:||::||..|...|||||||:|::|..|| .:....:||:|..|:|.:|:
plant   478 AIKETLANDEEKVGADIVKKALSYPLKLIAKNAGVNGSVVSEKVLSSDNPKHGYNAATGKYEDLM 542

  Fly   511 EKGIIDPTKVVRTAITDASGVASLLTTAEAVVTEIPK-EDGAPAMPGMGGMG 561
            ..||||||||||..:..||.||.....::.||.||.: |..|||...|...|
plant   543 AAGIIDPTKVVRCCLEHASSVAKTFLMSDCVVVEIKEPESAAPAGNPMDNSG 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	259/552 (47%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	252/525 (48%)
Cpn60beta3	NP_001032083.1	PLN03167	1..597	CDD:215611	268/572 (47%)
Cpn60beta3	NP_001032083.1	groEL	51..597	CDD:237231	261/547 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D415781at2759
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780