DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60A and HSP60-3A

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_566466.1	Gene:	HSP60-3A / 820599	AraportID:	AT3G13860	Length:	572	Species:	Arabidopsis thaliana

Alignment Length:	572	Identity:	297/572 - (51%)
Similarity:	409/572 - (71%)	Gaps:	12/572 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFRLPVSLAR---SSISRQL------AMRGY-AKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKG 55
            |:|:...|:.   ||.||:|      :.|.| |||:.||...||.|||||..:|:||.|||||||
plant     1 MYRVLSKLSSSIGSSTSRKLVSGRIISSRNYAAKDISFGIGARAAMLQGVSEVAEAVKVTMGPKG 65

  Fly    56 RNVIIEQSWGSPKITKDGVTVAKSIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIA 120
            ||||||.|:|.||||||||||||||..:.|.:||||:||:.||:.||:.||||||.||||.:||.
plant    66 RNVIIESSYGGPKITKDGVTVAKSISFQAKAKNIGAELVKQVASATNKVAGDGTTCATVLTQAIL 130

  Fly   121 KEGFEKISKGANPVEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQVATISANGDQAIGNLISEA 185
            .||.:.::.|.|.:::|.|:.:|:..|..:||:.:..:||||||.|||||||||::.||.||:.|
plant   131 IEGCKSVAAGVNVMDLRVGINMAIAAVVSDLKSRAVMISTPEEITQVATISANGEREIGELIARA 195

  Fly   186 MKKVGRDGVITVKDGKTLTDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALLLLSEKKISSV 250
            |:|||::|||||.||.||.:||||:||||..|||||||||...|..|.|.::.::|:.|||||.:
plant   196 MEKVGKEGVITVADGNTLDNELEVVEGMKLARGYISPYFITDEKTQKCELENPIILIHEKKISDI 260

  Fly   251 QSIIPALELANAQRKPLVIIAEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKSTLTDMAIA 315
            .|::..||.|....:||:|:|||::.:||:.|::|:...||:|.|:||||||||||::|.|:|:.
plant   261 NSLLKVLEAAVKSSRPLLIVAEDVESDALAMLILNKHHGGLKVCAIKAPGFGDNRKASLDDLAVL 325

  Fly   316 SGGIVFGDDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIEDTTSE 380
            :|..|..::..| .||.::...||...:|.:|:|||::|.|.|.|..:..|..:::...|.:||.
plant   326 TGAEVISEERGL-SLEKIRPELLGTAKKVTVTRDDTIILHGGGDKKLIEERCEELRSANEKSTST 389

  Fly   381 YEKEKLQERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAVEEGIVPGGGTALLRCIE 445
            :::||.||||::|:.|||:.:|||:||.||.|:||||.||||||||||||||:||||.|||...:
plant   390 FDQEKTQERLSKLSGGVAVFKVGGASESEVGERKDRVTDALNATRAAVEEGIIPGGGVALLYATK 454

  Fly   446 KLEGVETTNEDQKLGVEIVRRALRMPCMTIAKNAGVDGAMVVAK-VENQAGDYGYDALKGEYGNL 509
            .|:.::|.||||:.||:||:.||:.|..|||.|||.||::||.| :|....::|:||.||:|.::
plant   455 ALDNLQTENEDQRRGVQIVQNALKAPAFTIAANAGYDGSLVVGKLLEQDDCNFGFDAAKGKYVDM 519

  Fly   510 IEKGIIDPTKVVRTAITDASGVASLLTTAEAVVTEIPKEDGAPAMPGMGGMG 561
            ::.|||||.||:|||:|||:.|:.||||.||.|.....|:....:|.|..||
plant   520 VKAGIIDPVKVIRTALTDAASVSLLLTTTEASVLVKADENTPNHVPDMASMG 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	288/544 (53%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	281/520 (54%)
HSP60-3A	NP_566466.1	PTZ00114	20..570	CDD:185455	288/550 (52%)
HSP60-3A	NP_566466.1	GroEL	34..552	CDD:239460	280/518 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	580	1.000	Domainoid score	I40
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	652	1.000	Inparanoid score	I167
OMA	1	1.010	-	-		QHG61846
OrthoDB	1	1.010	-	-		D415781at2759
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		mtm993
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1504
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840