DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60A and HSP60-2

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_850203.1	Gene:	HSP60-2 / 817883	AraportID:	AT2G33210	Length:	585	Species:	Arabidopsis thaliana

Alignment Length:	585	Identity:	339/585 - (57%)
Similarity:	453/585 - (77%)	Gaps:	15/585 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFRLPVSLA-RSSISRQL---------AMRGY-AKDVRFGPEVRAMMLQGVDVLADAVAVTMGPK 54
            |:||..::| ::.|:|:.         :.|.| |||:|||.|.||:||:||:.|||||.||||||
plant     1 MYRLVSNVASKARIARKCTSQIGSRLNSTRNYAAKDIRFGVEARALMLRGVEDLADAVKVTMGPK 65

  Fly    55 GRNVIIEQSWGSPKITKDGVTVAKSIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAI 119
            |||||||||||:||:||||||||||||.||:.:|:||.||:.|||.||:.||||||.||||.|||
plant    66 GRNVIIEQSWGAPKVTKDGVTVAKSIEFKDRIKNVGASLVKQVANATNDVAGDGTTCATVLTRAI 130

  Fly   120 AKEGFEKISKGANPVEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQVATISANGDQAIGNLISE 184
            ..||.:.::.|.|.:::|||:.|||:||..||::.:|.:||.||||||.|||||||:.||.||::
plant   131 FTEGCKSVAAGMNAMDLRRGIKLAVDTVVTNLQSRARMISTSEEIAQVGTISANGDREIGELIAK 195

  Fly   185 AMKKVGRDGVITVKDGKTLTDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALLLLSEKKISS 249
            ||:.||::||||::|||||.:||||:||||.||||||||||.:.|..|.|.:|.|:|:.|||||:
plant   196 AMETVGKEGVITIQDGKTLFNELEVVEGMKIDRGYISPYFITNPKTQKCELEDPLILIHEKKISN 260

  Fly   250 VQSIIPALELANAQRKPLVIIAEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKSTLTDMAI 314
            :.:::..||||..:::||:|:|||::.:||:||::|:|:..::|.||||||||:|||:.|.|:|.
plant   261 INAMVKVLELALKKQRPLLIVAEDVESDALATLILNKLRANIKVCAVKAPGFGENRKANLHDLAA 325

  Fly   315 ASGGIVFGDDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIEDTTS 379
            .:|..|..::..: .|:::.:|..|...:|.::||||::|.|.|.|..:..|..||:..:|.:||
plant   326 LTGAQVITEELGM-NLDNIDLSMFGNCKKVTVSKDDTVVLDGAGDKQAIGERCEQIRSMVEASTS 389

  Fly   380 EYEKEKLQERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAVEEGIVPGGGTALLRCI 444
            :|:|||||||||:|:.|||:|::||:||.||:||||||.||||||:||||||||||||.|||...
plant   390 DYDKEKLQERLAKLSGGVAVLKIGGASETEVSEKKDRVTDALNATKAAVEEGIVPGGGVALLYAS 454

  Fly   445 EKLEGVETTNEDQKLGVEIVRRALRMPCMTIAKNAGVDGAMVVAK-VENQAGDYGYDALKGEYGN 508
            ::||.:.|.|.|||:||:|::.||:.|..|||.||||:||:||.| :|....|.||||.||||.:
plant   455 KELEKLSTANFDQKIGVQIIQNALKTPVYTIASNAGVEGAVVVGKLLEQDNPDLGYDAAKGEYVD 519

  Fly   509 LIEKGIIDPTKVVRTAITDASGVASLLTTAEAVVTEIP-KEDGAPAMPGMGGMGGMGGMGGMGGM 572
            :|:.|||||.||:|||:.||:.|:|||||.|||||||| ||..:|.|.| |||||||||||||||
plant   520 MIKAGIIDPLKVIRTALVDAASVSSLLTTTEAVVTEIPTKEVASPGMGG-GGMGGMGGMGGMGGM 583

Fly 573 572
plant 584 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	316/548 (58%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	306/520 (59%)
HSP60-2	NP_850203.1	PTZ00114	21..560	CDD:185455	313/539 (58%)
HSP60-2	NP_850203.1	GroEL	35..555	CDD:239460	306/520 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	580	1.000	Domainoid score	I40
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	652	1.000	Inparanoid score	I167
OMA	1	1.010	-	-		QHG61846
OrthoDB	1	1.010	-	-		D415781at2759
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		mtm993
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1504
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840