DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60A and Bbs10

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_082190.1	Gene:	Bbs10 / 71769	MGIID:	1919019	Length:	713	Species:	Mus musculus

Alignment Length:	468	Identity:	91/468 - (19%)
Similarity:	162/468 - (34%)	Gaps:	126/468 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIELKDKFQNIGAKLVQDVANNT 101
            |:..:||.......:||:|..|:..:..|...:::||..:.:::.|:...    |:::....::.
Mouse    11 LRVAEVLESIANRCVGPEGGQVLCTKPTGEVLLSRDGGCLLEALHLEHPL----ARMIVACVSSH 71

  Fly   102 NEEAGDGTTTATVLARAIAKEGFEKISKGANPVEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQ 166
            .::.|||..|..:..                 ..:.||:....|..||:.        |.|.|..
Mouse    72 LKKTGDGAKTFIIFL-----------------CHLLRGLHAIGEKGKDSF--------TSENIQS 111

  Fly   167 VATISANGDQAIGNLISEAMKKVGRDGVITVKDGKTLTDELEVIEGMKFDRGYISPYFINSSKGA 231
            ......|..|  ...||:|::..             .|..|..|......|.|:| .|.:|::|.
Mouse   112 HERHWKNCCQ--WKSISQALQTF-------------QTQTLGCIVDRSLSRHYLS-VFSSSTEGR 160

  Fly   232 KVEFQDALLLLSEK-----------------------KISSVQSIIPALELAN---AQRKPLVII 270
            |: .:.:|.||.|.                       |..:.:|.:...||.:   |:....|..
Mouse   161 KL-CRHSLELLLEAYFCGRVGRNNHRFISQLMCDYVFKCMACESGVEVFELLDHCFAELNVGVTG 224

  Fly   271 AEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKSTLTDM-----AIASGGIVFGDDADLVKL 330
            ....|...:..||:.|      ..::..|..||.|...:|::     :.|....|...:...
Mouse   225 LPVSDSRIIDGLVLPR------DFSMYCPADGDIRMVIVTEILQPQFSSAGSEFVLNSETQF--- 280

  Fly   331 EDVKVSDLGQVGEVVIT-KDDTLL--LKGKG--------KKDDVL---RRANQIKDQIEDTTSEY 381
                     |..:..|| :..|::  |:|:.        |:.|::   .|.|.|  .:.:..|.
Mouse   281 ---------QASQCWITDRTKTVMNHLRGQNVKLLLTSVKQPDLVIYCARLNSI--SVVECLSA- 333

  Fly   382 EKEKLQERLARLASGVALLRVGGSSEVE-----------VNEKKDRVHDALNATRAAVEEGIVPG 435
            |:..|.:|:..| |...|..|....|:.           :...|..||..|.:|.|.:...:|..
Mouse   334 EEVSLVQRITGL-SPCVLPEVASQCEISDSTLVKFCKPLILRSKRYVHLGLISTCAFIPHSMVLC 397

  Fly   436 GGTALLRCIEKLE 448
            |  .:|..:|:.|
Mouse   398 G--PVLGLVEQHE 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	91/468 (19%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	91/468 (19%)
Bbs10	NP_082190.1	chaperonin_like	7..>111	CDD:295468	24/128 (19%)
		Cpn60_TCP1	13..>424	CDD:278544	90/466 (19%)
		CNH	111..>209	CDD:295303	21/114 (18%)
		chaperonin_like	<587..695	CDD:295468
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900