Protein Alignment Hsp60A and Mkks

DIOPT Version :9

• Sequence 1: NP_511115.2
• Gene: Hsp60A / 32045
• FlyBaseID: FBgn0015245
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_001135418.1
• Gene: Mkks / 59030
• MGIID: 1891836
• Length: 570
• Species: Mus musculus
• Alignment Length: 591
• Identity: 103/591 - (17%)
• Similarity: 196/591 - (33%)
• Gaps: 183/591 - (30%)

  Fly    40 VDVLADAVAVTMGPKGRNVIIEQSWGS-PKITKDGVTVAKSIELKDKFQNIGAKLVQDVANNTNE 103
            :.||...:|...||.||...:....|. ...|.....:.:::.:......|   |...|.|:.:.
Mouse    26 LSVLKGVIASCYGPSGRLKQLHNGLGGCVYTTSQSSALLRNLSVTHPVLKI---LTSSVQNHVSC 87

  Fly   104 EAGDGTTTATVLARAIAKEGFEKIS-KGANPVEIRRGVM-LAVETVKDNLKTMSRPV---STPEE 163
            .:..|..||.:....|  |..:::. ..|..:::.:.:: |....:|....:...||   ||...
Mouse    88 FSDCGLFTAILCCNLI--ENIQRLDLTPATAIKLNKYLLSLCTSYLKSEACSCRIPVDFRSTHTF 150

  Fly   164 IAQVATI---------SANGDQAIGNLI-----------SEAMKKVGRDGVITVKDGKTLTDELE 208
            ::.|.:|         :......||.||           :|....:|:..::.:| |:.:||. .
Mouse   151 LSLVHSILTSKPACMLTRKETDHIGALILKAFLLTIPESTEERMVLGKSIIVPLK-GQRVTDS-T 213

  Fly   209 VIEGMKFDRGYI-----------------------SPYFINSSKGA-----KVEFQDA----LLL 241
            |:.|:..:...:                       |..|.|:.:|.     :|..::|    ||.
Mouse   214 VLPGLLIEASEVQLRRLLPTQKASGLRVALFCTSLSGDFSNAGEGVVVAHYQVSLENAVLEQLLN 278

  Fly   242 LSEKKISS------VQSII-PALELANAQRKPLVIIAEDIDG----EALSTLVVNRLKIGL---- 291
            |..:.::.      .|.:| |:|:...::|.   ::|.|..|    |:||. |.....||.
Mouse   279 LGRRLVTDHVDLVLCQKVIHPSLKQFFSERH---VMAIDRVGVTLMESLSK-VTGATPIGSLNPI 339

  Fly   292 ------QVAAVKAPGFGDN-------RKSTLTDMAIASGGIVFGDDADLVKLEDVKVSDLGQVGE 343
                  .|..|.:..||..       .::|:..:.:.|.    .|.|    .|::|::....:..
Mouse   340 VSTTYGSVKDVCSARFGSKHFFHLLPNEATVCTLLLCSR----NDTA----WEELKLTCQTAMHV 396

  Fly   344 VVITKDDTLLLKGKGKKDDVLRRANQIKDQIEDTTSEYEKEKLQERLARLASGVALLRVGGSSEV 408
            :.:|..:..:|.|.|..:..|              :.|.:.|:..      ...|::|..|.::.
Mouse   397 LQLTIKEPWVLLGGGCTETHL--------------AAYVRHKVHH------EAEAIVRDDGCTQA 441

  Fly   409 EVNEKKDRVHDALNATRAAVEEGIVPGGGTALL-------------------------RCIEKLE 448
            :::...:....||.:...::|.    .||..|:                         ||
Mouse   442 KLHVAAEAFCSALESVAGSLEH----DGGEILIDTKYGHLWSCQADSASVGNWSDTLSRC----- 497

  Fly   449 GVETTNEDQKLGVEIVRRA--------------------LRMPCMTIAKNAGVDGAMVVAKVENQ 493
            |....|..::|...::|..                    |.:.|.|    |.:.|..|..:..|.
Mouse   498 GCGLYNSQEELSWSVLRSTYHPFAPQTCLPQAALGSASNLTVDCFT----AKLSGLQVAVETANL 558

  Fly   494 AGDYGY 499
            ..|..|
Mouse   559 ILDLSY 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	103/591 (17%)
		GroEL	24..544	CDD:239460	103/591 (17%)
Mkks	NP_001135418.1	Cpn60_TCP1	29..569	CDD:395068	102/588 (17%)
		Substrate-binding apical domain. /evidence=ECO:0000250|UniProtKB:Q9NPJ1	198..370		33/177 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900