Protein Alignment Hsp60A and HSPD1

DIOPT Version :9

• Sequence 1: NP_511115.2
• Gene: Hsp60A / 32045
• FlyBaseID: FBgn0015245
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_002147.2
• Gene: HSPD1 / 3329
• HGNCID: 5261
• Length: 573
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 426/577 - (73%)
• Similarity: 496/577 - (85%)
• Gaps: 9/577 - (1%)

  Fly     1 MFRLP-VSLARSSISRQLA---MRGYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIE 61
            |.||| |......:||.||   .|.|||||:||.:.||:||||||:||||||||||||||.||||
Human     1 MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIE 65

  Fly    62 QSWGSPKITKDGVTVAKSIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEK 126
            |||||||:|||||||||||:||||::||||||||||||||||||||||||||||||:||||||||
Human    66 QSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEK 130

  Fly   127 ISKGANPVEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQVATISANGDQAIGNLISEAMKKVGR 191
            ||||||||||||||||||:.|...||..|:||:||||||||||||||||:.|||:||:|||||||
Human   131 ISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGR 195

  Fly   192 DGVITVKDGKTLTDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALLLLSEKKISSVQSIIPA 256
            .|||||||||||.||||:|||||||||||||||||:|||.|.|||||.:|||||||||:|||:||
Human   196 KGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPA 260

  Fly   257 LELANAQRKPLVIIAEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKSTLTDMAIASGGIVF 321
            ||:|||.||||||||||:|||||||||:||||:||||.||||||||||||:.|.|||||:||.||
Human   261 LEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVF 325

  Fly   322 GDDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIEDTTSEYEKEKL 386
            |::...:.||||:..|||:||||::||||.:||||||.|..:.:|..:|.:|::.||||||||||
Human   326 GEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKL 390

  Fly   387 QERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAVEEGIVPGGGTALLRCIEKLEGVE 451
            .||||:|:.|||:|:|||:|:||||||||||.|||||||||||||||.|||.||||||..|:.:.
Human   391 NERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLT 455

  Fly   452 TTNEDQKLGVEIVRRALRMPCMTIAKNAGVDGAMVVAKVENQAGDYGYDALKGEYGNLIEKGIID 516
            ..|||||:|:||::|.|::|.|||||||||:|:::|.|:...:.:.||||:.|::.|::||||||
Human   456 PANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIID 520

  Fly   517 PTKVVRTAITDASGVASLLTTAEAVVTEIPKEDGAPAMPGMGGMGGMGGMGGMGGMM 573
            ||||||||:.||:||||||||||.||||||||:   ..||||.|||||  |||||.|
Human   521 PTKVVRTALLDAAGVASLLTTAEVVVTEIPKEE---KDPGMGAMGGMG--GGMGGGM 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	405/539 (75%)
		GroEL	24..544	CDD:239460	393/519 (76%)
HSPD1	NP_002147.2	GroEL	28..548	CDD:239460	393/519 (76%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147668
Domainoid	1	1.000	750	1.000	Domainoid score	I92
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1626
Inparanoid	1	1.050	822	1.000	Inparanoid score	I469
Isobase	1	0.950	-	0	Normalized mean entropy	S222
OMA	1	1.010	-	-		QHG61846
OrthoDB	1	1.010	-	-		D183447at33208
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		otm40974
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	LDO	PTHR45633
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R572
SonicParanoid	1	1.000	-	-		X1504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750