DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60A and CCT6

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	121/574 - (21%)
Similarity:	223/574 - (38%)	Gaps:	135/574 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIELKDKFQNIGAKLVQDVA 98
            |:.:.....|.|.:...:||||...::....|..||||||..:...:::    |:..|.::...:
  Fly    21 AINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLHEMQI----QHPTASMIARAS 81

  Fly    99 NNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPVEIRRGVMLAVETVKDNLKTMSRPVSTPEE 163
            ...::..||||||..:|...:.|:....:|:|.:|..:..|    .|..:|....:...|..|.|
  Fly    82 TAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDG----FEKARDKALEVLDQVKVPVE 142

  Fly   164 I-----AQVA--TISANGDQAIGNLISEAMKKVGRDGVITVKDG-KTLTDELEVIE--------- 211
            |     .:||  ::......|:.:|:::    |..:.|:|:... ||...:|.::|
  Fly   143 INKKNLVEVANTSLKTKVHPALADLLTD----VCVNAVLTIASADKTKPVDLHMVELMEMQHKSD 203

  Fly   212 -------GMKFDRGYISP---------YFINSSKGAKVEFQDA------LLLLSEKKISSVQSII 254
                   |:..|.|...|         |.:.::  ..:|::.|      ....:|::.:.|::
  Fly   204 TDTQLVRGLVMDHGARHPDMPKRLENAYILTAN--VSLEYEKAEVNSGFFYKTAEEREAFVRA-- 264

  Fly   255 PALELANAQRKPLVIIAEDI-DGEALSTLVVNRLKIG-LQVAAVKAPGFGDNRKSTLTDM---AI 314
             ..|..:.:.|.::.:...: ||...:.:::|:..|. :.:.|:...|....|::...:|   ::
  Fly   265 -EREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALRRAKRRNMERLSL 328

  Fly   315 ASGGIVFGDDADLVKLEDVKVSDLGQVG---EVVITKDD-------------TLLLKGKGKKDDV 363
            |.||....      ..:|::...||..|   |.|:.::.             |:|:||..|
  Fly   329 ACGGTAMN------SFDDLQEEHLGYAGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNK---- 383

  Fly   364 LRRANQIKDQIEDTTSEYEKEKLQERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAV 428
             ....||||.|.|.                      ||                  |:|.|.|
  Fly   384 -HTITQIKDAIRDG----------------------LR------------------AINNTIA-- 405

  Fly   429 EEGIVPGGGTALLRCIEKLEGV-ETTNEDQKLGVEIVRRALRMPCMTIAKNAGVDGAMVVAK--V 490
            ::.:|||.|...:|...:|... :|.....:|.|:....||.:...|:|.|:|.|....:.|  |
  Fly   406 DKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADALLVIPKTLAVNSGYDAQDTIVKLTV 470

  Fly   491 ENQAGD--YGYDALKGEYGNLIEKGIIDPTKVVRTAITDASGVASLLTTAEAVV 542
            |::...  .|.|...||....::.|:.|...|.:..:...|.:||.|...:.|:
  Fly   471 EDRLSPELVGLDLATGEPMKPVDLGVYDNYIVKKQILNSCSIIASNLLLVDEVM 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	121/574 (21%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	121/574 (21%)
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	121/574 (21%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	121/574 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453448
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830