DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60A and Cct2

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	XP_038934664.1	Gene:	Cct2 / 299809	RGDID:	1359143	Length:	561	Species:	Rattus norvegicus

Alignment Length:	601	Identity:	134/601 - (22%)
Similarity:	242/601 - (40%)	Gaps:	135/601 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VSLARSSISRQLAMRGYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSW--GSPK 68
            :|||..:|.:..|....|:..|....:      |...:.|.|..|:||||.:.|:..|.  .|..
  Rat    30 LSLAPVNIFKAGADEERAETARLSSFI------GAIAIGDLVKSTLGPKGMDKILLSSGRDASLM 88

  Fly    69 ITKDGVTVAKSIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANP 133
            :|.||.|:.|:|.:    .|..||::.|::...::|.|||||:.||||..:.:|....|:|..:|
  Rat    89 VTNDGATILKNIGV----DNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHP 149

  Fly   134 VEIRRGVMLAVETVKDNLKTM-----SRPVSTPEEIAQVATISANGDQAIGNLIS---EAMKKVG 190
            ..|..|...|.:..::.|.:.     |..|...:::..:|     |......|::   :...|:.
  Rat   150 QTIIAGWREATKAAREALLSSAVDHGSDEVKFWQDLMNIA-----GTTLSSKLLTHHKDHFTKLA 209

  Fly   191 RDGVITVKDGKTLTDELEVIEGMK----------FDRGYISPYFINSSKGAKVEFQDALLLLSEK 245
            .:.|:.:|.    :..||.|..:|          .|.|::....|..::..::|  :|.:|::..
  Rat   210 VEAVLRLKG----SGNLEAIHVIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIE--NAKILIANT 268

  Fly   246 KISS-----------VQSIIPALELANAQRKPLVIIAEDIDGEALSTLVVNRLKI---------G 290
            .:.:           |.|.....|:.:|:::.:....|.|....::.. :||..|         .
  Rat   269 GMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCF-INRQLIYNYPEQLFGA 332

  Fly   291 LQVAAVKAPGFGDNRKSTLTDMAIASGGIVFG--DDADLVKLEDVKVSDLGQVGEVVITKDDTLL 353
            ..|.|::...|....:     :|:.:||.:..  |..:||||...|:     :.||:|.:|..:.
  Rat   333 AGVMAIEHADFAGVER-----LALVTGGEIASTFDHPELVKLGSCKL-----IEEVMIGEDKLIH 387

  Fly   354 LKGKGKKDDVLRRANQIKDQIEDTTSEYEKEKLQERLARLASGVAL-----LRVGGSSEVEVNEK 413
            .                                        |||||     :.:.|:::..::|.
  Rat   388 F----------------------------------------SGVALGEACTIVLRGATQQILDEA 412

  Fly   414 KDRVHDALNATRAAVEE-GIVPGGGTALLRCIEKLEG------VETTNEDQKLGVEIVRRALRMP 471
            :..:||||......|:: ..|.|||     |.|.|..      ...|...:.:.:|...:||||.
  Rat   413 ERSLHDALCVLAQTVKDPRTVYGGG-----CSEMLMAHAVTMLASRTPGKEAVAMESFAKALRML 472

  Fly   472 CMTIAKNAGVDGAMVVAKVENQAGD----YGYDALKGEYGNLIEKGIIDPTKVVRTAITDASGVA 532
            ...||.|||.|.|.:||::.....:    .|.|..:|..|::...||.:..:|.|..:..|:..|
  Rat   473 PTIIADNAGYDSADLVAQLRAAHSEGRITAGLDMKEGSIGDMAVLGITESFQVKRQVLLSAAEAA 537

  Fly   533 SLLTTAEAVVTEIPKE 548
            .::...:.::...|::
  Rat   538 EVILRVDNIIKAAPRK 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	131/595 (22%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	127/577 (22%)
Cct2	XP_038934664.1	TCP1_beta	37..553	CDD:239452	131/592 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810