DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60A and Cct7

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001100073.1	Gene:	Cct7 / 297406	RGDID:	1306422	Length:	544	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	131/554 - (23%)
Similarity:	228/554 - (41%)	Gaps:	64/554 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIELKDKFQNIGAKLVQDVANNT 101
            :....|:|:||..|:||:|.:.:|....|...|:.||.|:.|.:::    .:..||.:.|:|.:.
  Rat    26 ISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDV----VHPAAKTLVDIAKSQ 86

  Fly   102 NEEAGDGTTTATVLARAIAKEGFEKISKGANPVEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQ 166
            :.|.|||||:.|:||....|:....:.:|.:|..|.|....|.:...:.:|.::..|...:::.|
  Rat    87 DAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKQDKVEQ 151

  Fly   167 VATISANGDQAIGNLISEAMKKVGRDGVITVK---DGKTLTDE---LEVIEGMKFDRGYISPYFI 225
            ...:......|:.:      |.:.:..|...|   |...:.||   |::|...|...|.:....:
  Rat   152 RKMLEKCAMTALSS------KLISQQKVFFAKMVVDAVMMLDELLQLKMIGIKKVQGGALEESRL 210

  Fly   226 NSSKGAKVEFQDALLLLSEKKISSVQSIIPALELA------NAQRKPLVIIAED----IDGEALS 280
            .:....|..|..|...:..||..:.:..:..:||.      ||:.:  |...||    :|.|  .
  Rat   211 VAGVAFKKTFSYAGFEMQPKKYKNPKIALLNVELELKAEKDNAEIR--VHTVEDYQAIVDAE--W 271

  Fly   281 TLVVNRL-KI---GLQVAAVKAPGFGDNRKSTLTDMAIASGGIVFGDDADLVKLEDVKVSDLGQV 341
            .::.::| ||   |.:|...|.| .||.......|..:...|        .|..||:|.:.:. .
  Rat   272 NILYDKLEKIHQSGAKVILSKLP-IGDVATQYFADRDMFCAG--------RVPEEDLKRTMMA-C 326

  Fly   342 GEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIEDTTSEYEKEKLQERLARLASGVALLRVGGSS 406
            |..:.|..:.|:       .|||.|. |:   .|:|....|:........:..:...:||.|...
  Rat   327 GGSIQTSVNALI-------PDVLGRC-QV---FEETQIGGERYNFFTGCPKAKTCTIILRGGAEQ 380

  Fly   407 EVEVNEKKDRVHDALNATRAAVE-EGIVPGGGTALLRCIEKLEGV-ETTNEDQKLGVEIVRRALR 469
            .:|..|:.  :|||:...|.|:: :.:|.|||...:...:.|... .|....|:|.:....:||.
  Rat   381 FMEETERS--LHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALE 443

  Fly   470 MPCMTIAKNAGVDGAMVVAKVENQAGD----YGYDALKGEYGNLIEKGIIDPTKVVRTAITDASG 530
            :....:..|||.|...::.|:..:...    ||.|....:..:..:..:.:|..|...|:|.||.
  Rat   444 IIPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDINNEDIADNFQAFVWEPAMVRINALTAASE 508

  Fly   531 VASLLTTAEAVVTEIPKEDGAPAMPGMGGMGGMG 564
            .|.|:.:.:..:........||| |..|...|.|
  Rat   509 AACLIVSVDETIKNPRSTVDAPA-PAAGRGRGQG 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	124/537 (23%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	124/532 (23%)
Cct7	NP_001100073.1	TCP1_eta	5..525	CDD:239456	124/535 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810