DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60A and Cct6a

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001028856.1	Gene:	Cct6a / 288620	RGDID:	1304763	Length:	531	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	135/581 - (23%)
Similarity:	236/581 - (40%)	Gaps:	115/581 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RAMMLQGVDV-----LADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIELKDKFQNIGAK 92
            ||.....|::     |.|.:...:||||...::....|..|:||||..:...:::    |:..|.
  Rat    15 RAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQI----QHPTAS 75

  Fly    93 LVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPVEIRRGVMLA-------VETVKDN 150
            |:..||...::..|||||:..::...:.|:....||:|.:|..|..|...|       :|.||.:
  Rat    76 LIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVS 140

  Fly   151 LKTMSRPVSTPEEIAQVA--TISANGDQAIGNLISEAMKKVGRDGVITV--KD------------ 199
             |.|.|     |.:..||  ::.......:.::::||:.    |.::.:  ||
  Rat   141 -KEMDR-----ETLIDVARTSLRTKVHAELADVLTEAVV----DSILAIRKKDEPIDLFMVEIME 195

  Fly   200 --GKTLTDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALLLLSEKKISS---VQSIIPALEL 259
              .|:.|| ..:|.|:..|.|...|......:.|.:...:..|...:.:::|   .:|.....:|
  Rat   196 MKHKSETD-TSLIRGLVLDHGARHPDMKKRVENAYILTCNVSLEYEKTEVNSGFFYKSAEEREKL 259

  Fly   260 ANAQR-------KPLVIIAEDIDGEA-LSTLVVNRLKIG-LQVAAVKAPGFGDNRKSTLTDM--- 312
            ..|:|       |.:|.:.:.:.|:: ...:|:|:..|. ..:.|:...|....|::...:|
  Rat   260 VKAERKFIEDRVKKIVELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRNMERL 324

  Fly   313 AIASGGIVFGDDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIEDT 377
            .:|.|||.      |...:|:....||..|.|                             .|.|
  Rat   325 TLACGGIA------LNSFDDLNPDCLGHAGLV-----------------------------YEYT 354

  Fly   378 TSEYEKEKLQERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAVEEG-IVPGGGTALL 441
            ..| ||....|:.....| |.|| |.|.::..:.:.||.:.|.|.|.:.|:::| :|||.|...:
  Rat   355 LGE-EKFTFIEKCNNPRS-VTLL-VKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEV 416

  Fly   442 RCIEKLEGVETTNEDQ-KLGVEIVRRALRMPCMTIAKNAGVDGAMVVAKVE---NQAGD-YGYDA 501
            ...|.|...:.:.:.: :|||:....||.:....:|:|:|.|....:.||:   :::|. .|.|.
  Rat   417 ALAEALIKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDL 481

  Fly   502 LKGEYGNLIEKGIIDPTKVVRTAITDASGVASLLTTAEAVVTEIPKEDGAPAMPGMGGMGG 562
            ..||.....|.|:.|...|.:..:...:.:|    |...:|.||.:       .||..:.|
  Rat   482 NTGEPMVAAEMGVWDNYCVKKQLLHSCTVIA----TNILLVDEIMR-------AGMSSLKG 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	132/566 (23%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	130/561 (23%)
Cct6a	NP_001028856.1	chap_CCT_zeta	3..530	CDD:274088	134/578 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900