DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60A and cct-1

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_495722.1	Gene:	cct-1 / 174318	WormBaseID:	WBGene00000377	Length:	549	Species:	Caenorhabditis elegans

Alignment Length:	590	Identity:	136/590 - (23%)
Similarity:	235/590 - (39%)	Gaps:	144/590 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIELKDKFQNIGAKL 93
            |..:|:..:.....:|:.|..::||.|.:.::....|...:|.||.|:.|.:|:    ::...|:
Worm    18 GQGIRSQNVTAAVAIANIVKSSLGPVGLDKMLVDDVGDVIVTNDGATILKQLEV----EHPAGKV 78

  Fly    94 VQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPVEIRRGVMLAVETVKDNLKTMSRPV 158
            :.::|...:||.|||||:..::|..:.|...|.:.:..:|..|..|..||   .|:.:|.:|..:
Worm    79 LVELAQLQDEEVGDGTTSVVIVAAELLKRADELVKQKVHPTTIINGYRLA---CKEAVKYISENI 140

  Fly   159 S-TPEEIAQVATISAN---------GDQA--IGNLISEAMK--KVGRDGVITV---------KDG 200
            | |.:.|.:.:.::|.         |..|  .|.|:.:|.:  :|..:|.:|.         ..|
Worm   141 SFTSDSIGRQSVVNAAKTSMSSKIIGPDADFFGELVVDAAEAVRVENNGKVTYPINAVNVLKAHG 205

  Fly   201 KTLTDELEVIEGMKFDRGY---------ISPYFINSSKGAKVEFQDALLLLSEKKISSVQSII-- 254
            |:..:.:.|       :||         ..|..:.::|.|.::|.    |:..|....:..::
Worm   206 KSARESVLV-------KGYALNCTVASQAMPLRVQNAKIACLDFS----LMKAKMHLGISVVVED 259

  Fly   255 PALELANAQRKPLVIIAEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGD---------------- 303
            || :|...:|:...|....||         ..||.|..| .:...|..|
Worm   260 PA-KLEAIRREEFDITKRRID---------KILKAGANV-VLTTGGIDDLCLKQFVESGAMAVRR 313

  Fly   304 NRKSTLTDMAIASGGIVFGDDADLVKLEDVKVSDLGQVGEVV---ITKDDTLLLKGKGKKDDVLR 365
            .:||.|..:|.|:|..:....|.|...|....|.||...|:|   |:.|:.:|:||.
Worm   314 CKKSDLKRIAKATGATLTVSLATLEGDEAFDASLLGHADEIVQERISDDELILIKGP-------- 370

  Fly   366 RANQIKDQIEDTTSEYEKEKLQERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAVE- 429
                                    .:|.||.: :||  |:::|.::|.:..|||:|...|..:|
Worm   371 ------------------------KSRTASSI-ILR--GANDVMLDEMERSVHDSLCVVRRVLES 408

  Fly   430 EGIVPGGG---TALLRCIEKLEGVETTNEDQKLGVEIVRRALRMPCMTIAKNAGVDGAMVVAKVE 491
            :.:|.|||   |:|...:|..  .:|.:..::|.|.....||.:....:|.||..|...:|.|:.
Worm   409 KKLVAGGGAVETSLSLFLETY--AQTLSSREQLAVAEFASALLIIPKVLASNAARDSTDLVTKLR 471

  Fly   492 NQAGD------------YGYDALKGEYGNLIEKGIIDPTKVVRTAITDASGVASLLTTAEAVVTE 544
            .....            .|.|..:|...:..|.||::|.         .|.|.||....||.:|.
Worm   472 AYHSKAQLIPQLQHLKWAGLDLEEGTIRDNKEAGILEPA---------LSKVKSLKFATEAAITI 527

  Fly   545 IPKED 549
            :..:|
Worm   528 LRIDD 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	135/588 (23%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	134/583 (23%)
cct-1	NP_495722.1	chap_CCT_alpha	9..543	CDD:274081	136/590 (23%)
cct-1	NP_495722.1	TCP1_alpha	13..538	CDD:239451	136/590 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810