DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60A and Hspd1

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001343441.1	Gene:	Hspd1 / 15510	MGIID:	96242	Length:	573	Species:	Mus musculus

Alignment Length:	577	Identity:	429/577 - (74%)
Similarity:	500/577 - (86%)	Gaps:	9/577 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFRLPVSLAR-SSISRQLA---MRGYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIE 61
            |.|||..|.: ..:||.||   .|.|||||:||.:.||:||||||:||||||||||||||.||||
Mouse     1 MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIE 65

  Fly    62 QSWGSPKITKDGVTVAKSIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEK 126
            |||||||:|||||||||||:||||::||||||||||||||||||||||||||||||:||||||||
Mouse    66 QSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEK 130

  Fly   127 ISKGANPVEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQVATISANGDQAIGNLISEAMKKVGR 191
            ||||||||||||||||||:.|...||..|:||:||||||||||||||||:.|||:||:|||||||
Mouse   131 ISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGR 195

  Fly   192 DGVITVKDGKTLTDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALLLLSEKKISSVQSIIPA 256
            .|||||||||||.||||:|||||||||||||||||:|||.|.|||||.:|||||||||||||:||
Mouse   196 KGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPA 260

  Fly   257 LELANAQRKPLVIIAEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKSTLTDMAIASGGIVF 321
            ||:|||.||||||||||:|||||||||:||||:||||.||||||||||||:.|.|||||:||.||
Mouse   261 LEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVF 325

  Fly   322 GDDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIEDTTSEYEKEKL 386
            |::...:.||||:..|||:||||::||||.:||||||.|..:.:|..:|.:|::.||||||||||
Mouse   326 GEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKL 390

  Fly   387 QERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAVEEGIVPGGGTALLRCIEKLEGVE 451
            .||||:|:.|||:|:|||:|:||||||||||.|||||||||||||||.|||.||||||..|:.::
Mouse   391 NERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLK 455

  Fly   452 TTNEDQKLGVEIVRRALRMPCMTIAKNAGVDGAMVVAKVENQAGDYGYDALKGEYGNLIEKGIID 516
            ..|||||:|:||::|||::|.|||||||||:|:::|.|:...:.:.||||:.|::.|::||||||
Mouse   456 PANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIID 520

  Fly   517 PTKVVRTAITDASGVASLLTTAEAVVTEIPKEDGAPAMPGMGGMGGMGGMGGMGGMM 573
            ||||||||:.||:|||||||||||||||||||:   ..||||.|||||  |||||.|
Mouse   521 PTKVVRTALLDAAGVASLLTTAEAVVTEIPKEE---KDPGMGAMGGMG--GGMGGGM 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	408/539 (76%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	396/519 (76%)
Hspd1	NP_001343441.1	GroEL	28..548	CDD:239460	396/519 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837751
Domainoid	1	1.000	760	1.000	Domainoid score	I84
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1626
Inparanoid	1	1.050	829	1.000	Inparanoid score	I458
Isobase	1	0.950	-	0	Normalized mean entropy	S222
OMA	1	1.010	-	-		QHG61846
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		otm43045
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	LDO	PTHR45633
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R572
SonicParanoid	1	1.000	-	-		X1504
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740