DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60A and Cct7

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_031664.3	Gene:	Cct7 / 12468	MGIID:	107184	Length:	544	Species:	Mus musculus

Alignment Length:	552	Identity:	129/552 - (23%)
Similarity:	226/552 - (40%)	Gaps:	65/552 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIELKDKFQNIGAKLVQDVANNT 101
            :....|:|:||..|:||:|.:.:|....|...|:.||.|:.|.:::    .:..||.:.|:|.:.
Mouse    26 ISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDV----VHPAAKTLVDIAKSQ 86

  Fly   102 NEEAGDGTTTATVLARAIAKEGFEKISKGANPVEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQ 166
            :.|.|||||:.|:||....|:....:.:|.:|..|.|....|.:...:.:|.::..|...:::.|
Mouse    87 DAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKQDKVEQ 151

  Fly   167 VATISANGDQAIGNLISEAMKKVGRDGVITVK---DGKTLTDE---LEVIEGMKFDRGYISPYFI 225
            ...:......|:.:      |.:.:..|...|   |...:.||   |::|...|...|.:....:
Mouse   152 RKMLEKCAMTALSS------KLISQQKVFFAKMVVDAVMMLDELLQLKMIGIKKVQGGALEESQL 210

  Fly   226 NSSKGAKVEFQDALLLLSEKKISSVQSIIPALELA------NAQRKPLVIIAED----IDGEALS 280
            .:....|..|..|...:..||..:.:..:..:||.      ||:.:  |...||    :|.|  .
Mouse   211 VAGVAFKKTFSYAGFEMQPKKYKNPKIALLNVELELKAEKDNAEIR--VHTVEDYQAIVDAE--W 271

  Fly   281 TLVVNRL-KI---GLQVAAVKAPGFGDNRKSTLTDMAIASGGIVFGDDADLVKLEDVKVSDLGQV 341
            .::.::| ||   |.:|...|.| .||.......|..:...|        .|..||:|.:.:. .
Mouse   272 NILYDKLEKIHQSGAKVILSKLP-IGDVATQYFADRDMFCAG--------RVPEEDLKRTMMA-C 326

  Fly   342 GEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIEDTTSEYEKEKLQERLARLASGVALLRVGGSS 406
            |..:.|..:.|:       .|||... |:   .|:|....|:........:..:...:||.|...
Mouse   327 GGSIQTSVNALV-------PDVLGHC-QV---FEETQIGGERYNFFTGCPKAKTCTIILRGGAEQ 380

  Fly   407 EVEVNEKKDRVHDALNATRAAVE-EGIVPGGGTALLRCIEKLEGV-ETTNEDQKLGVEIVRRALR 469
            .:|..|:.  :|||:...|.|:: :.:|.|||...:...:.|... .|....|:|.:....:||.
Mouse   381 FMEETERS--LHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALE 443

  Fly   470 MPCMTIAKNAGVDGAMVVAKVENQAGD----YGYDALKGEYGNLIEKGIIDPTKVVRTAITDASG 530
            :....:..|||.|...::.|:..:...    ||.|.......:..:..:.:|..|...|:|.||.
Mouse   444 IIPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDINNENIADNFQAFVWEPAMVRINALTAASE 508

  Fly   531 VASLLTTAEAVVTEIPKEDGAPAMPGMG-GMG 561
            .|.|:.:.:..:.. |:....|..|..| |.|
Mouse   509 AACLIVSVDETIKN-PRSTVDPPAPSAGRGRG 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	124/537 (23%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	123/532 (23%)
Cct7	NP_031664.3	chap_CCT_eta	3..525	CDD:274086	124/536 (23%)
		TCP1_eta	5..525	CDD:239456	124/536 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..544		6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810