Protein Alignment Hsp60A and Cct3

DIOPT Version :10

• Sequence 1: NP_511115.2
• Gene: Hsp60A / 32045
• FlyBaseID: FBgn0015245
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_033966.1
• Gene: Cct3 / 12462
• MGIID: 104708
• Length: 545
• Species: Mus musculus
• Alignment Length: 605
• Identity: 119/605 - (19%)
• Similarity: 223/605 - (36%)
• Gaps: 164/605 - (27%)

  Fly    29 GPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIELKDKFQNIGAKL 93
            |.:|::..:.....:||.:...:|||....::....|...:|.||..:.:.|::    |:..||.
Mouse    19 GRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQV----QHPAAKS 79

  Fly    94 VQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPVEIRRGVMLAVETVKDNLKTMSRPV 158
            :.:::...:||.|||||:..:||..:.......:.:..:|..:.....:|::.:...||.:|.||
Mouse    80 MIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRMALDDMISTLKKISTPV 144

  Fly   159 STPEEIAQVATISANGDQAIGNLISEAMKKVGRDGVITVKDGKTLTDELE--------------- 208
            ........::.|:::....:.:..|.....:..|.|.||:..:....|::
Mouse   145 DVNNREMMLSIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGII 209

  Fly   209 ----VIEGMKFDRGYISPYFINSSKGAKVEFQDA-----------------------LLLLSEKK 246
                |:.|:..::....|......|..::...|:                       :|.:.|:.
Mouse   210 EDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEY 274

  Fly   247 ISSV-QSIIPALELANAQRKPLVIIAEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKSTLT 310
            |..: :.||        |.||.|:|.|    :.:|.|..:.| :...|.|::.....||.:
Mouse   275 IHQLCEDII--------QLKPDVVITE----KGISDLAQHYL-MRANVTAIRRVRKTDNNR---- 322

  Fly   311 DMAIASGGIVFGDDADLVKLEDVKVSDLG---------QVGEVVIT-----KDD---TLLLKGKG 358
             :|.|.|..:      :.:.|:::..|:|         ::|:...|     ||.   |:||:|..
Mouse   323 -IARACGARI------VSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGAS 380

  Fly   359 KKDDVLRRANQIKDQIEDTTSEYEKEKLQERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNA 423
            |  ::|                                         ||||.|     :.||:..
Mouse   381 K--EIL-----------------------------------------SEVERN-----LQDAMQV 397

  Fly   424 TR-AAVEEGIVPGGGTALLRCIEKLEGVETTNEDQKLGVE-----IVRRALRMPCMTIAKNAGVD 482
            .| ..::..:|||||.:.:.....|    |.......|||     .|.:||.:...|:.:|.|..
Mouse   398 CRNVLLDPQLVPGGGASEMAVAHAL----TEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGAS 458

  Fly   483 GAMVVAKV-----ENQAGDYGYDALKGEYGNLI---EKGIIDPTKVVRTAITDASGVASLLTTAE 539
            ...::..:     :.....:|   :.||.|.|:   |.||.:|..|.......|...|.||...:
Mouse   459 TIRLLTSLRAKHTQESCETWG---VNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRID 520

  Fly   540 AVVT-------EIPKEDGAP 552
            .:|:       :..::.|||
Mouse   521 DIVSGHKKKGDDQNRQTGAP 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	116/595 (19%)
Cct3	NP_033966.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		2/4 (50%)
		chap_CCT_gamma	6..529	CDD:274085	116/592 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..545		3/15 (20%)