DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60A and Cct2

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001345696.1	Gene:	Cct2 / 12461	MGIID:	107186	Length:	535	Species:	Mus musculus

Alignment Length:	596	Identity:	131/596 - (21%)
Similarity:	241/596 - (40%)	Gaps:	125/596 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VSLARSSISRQLAMRGYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSW--GSPK 68
            :|||..:|.:..|....|:..|....:      |...:.|.|..|:||||.:.|:..|.  .:..
Mouse     4 LSLAPVNIFKAGADEERAETARLSSFI------GAIAIGDLVKSTLGPKGMDKILLSSGRDAALM 62

  Fly    69 ITKDGVTVAKSIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANP 133
            :|.||.|:.|:|.:    .|..||::.|::...::|.|||||:.||||..:.:|....|:|..:|
Mouse    63 VTNDGATILKNIGV----DNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHP 123

  Fly   134 VEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQVATISANGDQAIGNLIS---EAMKKVGRDGVI 195
            ..|..|...|.:..::.|.:.:....:.|.......::..|......|::   :...|:..:.|:
Mouse   124 QTIISGWREATKAAREALLSSAVDHGSDEARFWQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVL 188

  Fly   196 TVKDGKTLTDELEVIEGMK----------FDRGYISPYFINSSKGAKVEFQDALLLLSEKKISS- 249
            .:|.    :..||.|..:|          .|.|::....|..::..::|  :|.:|::...:.:
Mouse   189 RLKG----SGNLEAIHVIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIE--NAKILIANTGMDTD 247

  Fly   250 ----------VQSIIPALELANAQRKPLVIIAEDIDGEALSTLVVNRLKI---------GLQVAA 295
                      |.|.....|:.:|:::.:....|.|....::.. :||..|         ...|.|
Mouse   248 KIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCF-INRQLIYNYPEQLFGAAGVMA 311

  Fly   296 VKAPGFGDNRKSTLTDMAIASGGIVFG--DDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKG 358
            ::...|....:     :|:.:||.:..  |..:||||...|:     :.||:|.:|..:..
Mouse   312 IEHADFAGVER-----LALVTGGEIASTFDHPELVKLGSCKL-----IEEVMIGEDKLIHF---- 362

  Fly   359 KKDDVLRRANQIKDQIEDTTSEYEKEKLQERLARLASGVAL-----LRVGGSSEVEVNEKKDRVH 418
                                                |||||     :.:.|:::..::|.:..:|
Mouse   363 ------------------------------------SGVALGEACTIVLRGATQQILDEAERSLH 391

  Fly   419 DALNATRAAVEE-GIVPGGGTALLRCIEKL------EGVETTNEDQKLGVEIVRRALRMPCMTIA 476
            |||......|:: ..|.|||     |.|.|      :....|...:.:.:|...:||||....||
Mouse   392 DALCVLAQTVKDPRTVYGGG-----CSEMLMAHAVTQLANRTPGKEAVAMESFAKALRMLPTIIA 451

  Fly   477 KNAGVDGAMVVAKVENQAGD----YGYDALKGEYGNLIEKGIIDPTKVVRTAITDASGVASLLTT 537
            .|||.|.|.:||::.....:    .|.|..:|..|::...||.:..:|.|..:..|:..|.::..
Mouse   452 DNAGYDSADLVAQLRAAHSEGHITAGLDMKEGTIGDMAVLGITESFQVKRQVLLSAAEAAEVILR 516

  Fly   538 AEAVVTEIPKE 548
            .:.::...|::
Mouse   517 VDNIIKAAPRK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	128/590 (22%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	124/572 (22%)
Cct2	NP_001345696.1	TCP1_beta	11..527	CDD:239452	128/587 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810