Protein Alignment Hsp60A and Cct2

DIOPT Version :10

• Sequence 1: NP_511115.2
• Gene: Hsp60A / 32045
• FlyBaseID: FBgn0015245
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_031662.2
• Gene: Cct2 / 12461
• MGIID: 107186
• Length: 535
• Species: Mus musculus
• Alignment Length: 596
• Identity: 131/596 - (21%)
• Similarity: 241/596 - (40%)
• Gaps: 125/596 - (20%)

  Fly     6 VSLARSSISRQLAMRGYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSW--GSPK 68
            :|||..:|.:..|....|:..|....:      |...:.|.|..|:||||.:.|:..|.  .:..
Mouse     4 LSLAPVNIFKAGADEERAETARLSSFI------GAIAIGDLVKSTLGPKGMDKILLSSGRDAALM 62

  Fly    69 ITKDGVTVAKSIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANP 133
            :|.||.|:.|:|.:    .|..||::.|::...::|.|||||:.||||..:.:|....|:|..:|
Mouse    63 VTNDGATILKNIGV----DNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHP 123

  Fly   134 VEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQVATISANGDQAIGNLIS---EAMKKVGRDGVI 195
            ..|..|...|.:..::.|.:.:....:.|.......::..|......|::   :...|:..:.|:
Mouse   124 QTIISGWREATKAAREALLSSAVDHGSDEARFWQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVL 188

  Fly   196 TVKDGKTLTDELEVIEGMK----------FDRGYISPYFINSSKGAKVEFQDALLLLSEKKISS- 249
            .:|.    :..||.|..:|          .|.|::....|..::..::|  :|.:|::...:.:
Mouse   189 RLKG----SGNLEAIHVIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIE--NAKILIANTGMDTD 247

  Fly   250 ----------VQSIIPALELANAQRKPLVIIAEDIDGEALSTLVVNRLKI---------GLQVAA 295
                      |.|.....|:.:|:::.:....|.|....::.. :||..|         ...|.|
Mouse   248 KIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCF-INRQLIYNYPEQLFGAAGVMA 311

  Fly   296 VKAPGFGDNRKSTLTDMAIASGGIVFG--DDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKG 358
            ::...|....:     :|:.:||.:..  |..:||||...|:     :.||:|.:|..:..
Mouse   312 IEHADFAGVER-----LALVTGGEIASTFDHPELVKLGSCKL-----IEEVMIGEDKLIHF---- 362

  Fly   359 KKDDVLRRANQIKDQIEDTTSEYEKEKLQERLARLASGVAL-----LRVGGSSEVEVNEKKDRVH 418
                                                |||||     :.:.|:::..::|.:..:|
Mouse   363 ------------------------------------SGVALGEACTIVLRGATQQILDEAERSLH 391

  Fly   419 DALNATRAAVEE-GIVPGGGTALLRCIEKL------EGVETTNEDQKLGVEIVRRALRMPCMTIA 476
            |||......|:: ..|.|||     |.|.|      :....|...:.:.:|...:||||....||
Mouse   392 DALCVLAQTVKDPRTVYGGG-----CSEMLMAHAVTQLANRTPGKEAVAMESFAKALRMLPTIIA 451

  Fly   477 KNAGVDGAMVVAKVENQAGD----YGYDALKGEYGNLIEKGIIDPTKVVRTAITDASGVASLLTT 537
            .|||.|.|.:||::.....:    .|.|..:|..|::...||.:..:|.|..:..|:..|.::..
Mouse   452 DNAGYDSADLVAQLRAAHSEGHITAGLDMKEGTIGDMAVLGITESFQVKRQVLLSAAEAAEVILR 516

  Fly   538 AEAVVTEIPKE 548
            .:.::...|::
Mouse   517 VDNIIKAAPRK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	124/572 (22%)
Cct2	NP_031662.2	TCP1_beta	11..527	CDD:239452	128/587 (22%)