Protein Alignment Hsp60A and CCT6B

DIOPT Version :9

• Sequence 1: NP_511115.2
• Gene: Hsp60A / 32045
• FlyBaseID: FBgn0015245
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_006575.2
• Gene: CCT6B / 10693
• HGNCID: 1621
• Length: 530
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 137/582 - (23%)
• Similarity: 230/582 - (39%)
• Gaps: 127/582 - (21%)

  Fly    24 KDVRFGPEV-RAMMLQGVDV-----LADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIEL 82
            |.|....|| ||.....|::     |.|.:...:||||...::....|..|:||||..:...:::
Human     5 KAVNSKAEVARARAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLDEMQI 69

  Fly    83 KDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPVEIRRGVMLA---- 143
                |:..|.|:..||...::..|||||:..::...:.|:....||:|.:|..|..|...|
Human    70 ----QHPTASLIAKVATAQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEAAKIKA 130

  Fly   144 ---VETVKDNLKTMSRPV-----------STPEEIAQVATISANGDQAIGNLISEAMKKVGRDG- 193
               :|.||.. |.|.|.:           ....|:|.|.|          .::.:::..|.|.|
Human   131 LEVLEEVKVT-KEMKRKILLDVARTSLQTKVHAELADVLT----------EVVVDSVLAVRRPGY 184

  Fly   194 -----VITVKDGK-TLTDELEVIEGMKFDRGYISPYF----------------------INSSKG 230
                 ::.:.:.| .|..:.::|:|:..|.|...|..                      :||...
Human   185 PIDLFMVEIMEMKHKLGTDTKLIQGLVLDHGARHPDMKKRVEDAFILICNVSLEYEKTEVNSGFF 249

  Fly   231 AKVEFQDALLLLSEKKI--SSVQSIIPALELANAQ-RKPLVII-AEDIDGEALSTLVVNRLKIGL 291
            .|...:...|:.:|:|.  ..||.||...:...|| .|..|:| .:.||..:|.:|.    |.|:
Human   250 YKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDSLA----KHGI 310

  Fly   292 QVAAVKAPGFGDNRKSTLTDMAIASGGIVFGDDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKG 356
             ||..:|      ::..:..:::|.||:...      ..||:.|..||..|.|
Human   311 -VALRRA------KRRNMERLSLACGGMAVN------SFEDLTVDCLGHAGLV------------ 350

  Fly   357 KGKKDDVLRRANQIKDQIEDTTSEYEKEKLQERLARLASGVALLRVGGSSEVEVNEKKDRVHDAL 421
                             .|.|..| ||....|......| |.|| |.|.::..:.:.||.:.|.|
Human   351 -----------------YEYTLGE-EKFTFIEECVNPCS-VTLL-VKGPNKHTLTQVKDAIRDGL 395

  Fly   422 NATRAAVEEG-IVPGGGTALLRCIEKLEGVETTNEDQ-KLGVEIVRRALRMPCMTIAKNAGVDGA 484
            .|.:.|:|:| :|||.|...:...|.|...:.:.:.: :|||:....||.:....:|:|||.|..
Human   396 RAIKNAIEDGCMVPGAGAIEVAMAEALVTYKNSIKGRARLGVQAFADALLIIPKVLAQNAGYDPQ 460

  Fly   485 MVVAKVENQAGD----YGYDALKGEYGNLIEKGIIDPTKVVRTAITDASGVASLLTTAEAVV 542
            ..:.||:.:..:    .|.|...||.....:.|:.|...|.:..:...:.:|:.:...:.::
Human   461 ETLVKVQAEHVESKQLVGVDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIM 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	137/582 (24%)
		GroEL	24..544	CDD:239460	137/582 (24%)
CCT6B	NP_006575.2	chap_CCT_zeta	3..530	CDD:274088	137/582 (24%)
		TCP1_zeta	23..526	CDD:239458	130/564 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810