DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60A and hspd1

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001096355.1	Gene:	hspd1 / 100124945	XenbaseID:	XB-GENE-980059	Length:	576	Species:	Xenopus tropicalis

Alignment Length:	573	Identity:	426/573 - (74%)
Similarity:	494/573 - (86%)	Gaps:	14/573 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PVSLARS-SISRQLAMRGYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPK 68
            |.|.|.| |:|||     |||||:||.:.||:||||||:||||||||||||||.|||||||||||
Frog    13 PASRALSLSLSRQ-----YAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPK 72

  Fly    69 ITKDGVTVAKSIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANP 133
            :|||||||||:|:||||::||||||||||||||||||||||||||||||:|||||||||||||||
Frog    73 VTKDGVTVAKAIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANP 137

  Fly   134 VEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQVATISANGDQAIGNLISEAMKKVGRDGVITVK 198
            ||||||||:||:.|...||..|:||:|||||||||||||||||.||.:||:|||:|||.||||||
Frog   138 VEIRRGVMMAVDAVIKELKNQSKPVTTPEEIAQVATISANGDQEIGKIISDAMKRVGRRGVITVK 202

  Fly   199 DGKTLTDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALLLLSEKKISSVQSIIPALELANAQ 263
            |||||.||||:|||||||||||||||||::||.|.|||||.||||||||||||||:||||:|||.
Frog   203 DGKTLHDELEIIEGMKFDRGYISPYFINTAKGQKCEFQDAYLLLSEKKISSVQSIVPALEIANAH 267

  Fly   264 RKPLVIIAEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKSTLTDMAIASGGIVFGDDADLV 328
            ||||||||||:|||||||||:||||:||||.||||||||||||:.|.||||:|||:|||::...:
Frog   268 RKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAISSGGVVFGEEGLTL 332

  Fly   329 KLEDVKVSDLGQVGEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIEDTTSEYEKEKLQERLARL 393
            .:||::..|.|:||||::|||||:||||||.|..:.:|..:|.:|:|.|.||||||||.||||:|
Frog   333 NIEDIQPHDFGKVGEVIVTKDDTMLLKGKGDKAQIEKRIQEIHEQLESTNSEYEKEKLNERLAKL 397

  Fly   394 ASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAVEEGIVPGGGTALLRCIEKLEGVETTNEDQK 458
            :.|||:::|||:|:||||||||||.|||||||||||||||.|||.||||||..||.:...||||:
Frog   398 SDGVAVIKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALEALNPANEDQR 462

  Fly   459 LGVEIVRRALRMPCMTIAKNAGVDGAMVVAKVENQAGDYGYDALKGEYGNLIEKGIIDPTKVVRT 523
            :|:||:||.|::|.|||||||||:|::||.|:.....:.||||:..|:.||:|||||||||||||
Frog   463 VGIEIIRRTLKIPAMTIAKNAGVEGSLVVEKIIQSPVEIGYDAMHAEFVNLVEKGIIDPTKVVRT 527

  Fly   524 AITDASGVASLLTTAEAVVTEIPKE--DGAPAMPGMGGMGGMGGM-GGMGGMM 573
            |:.||:|||||||||||||||||||  ||     ||.|||||||| |||||.|
Frog   528 ALMDAAGVASLLTTAEAVVTEIPKEEKDG-----GMAGMGGMGGMPGGMGGGM 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	404/538 (75%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	392/519 (76%)
hspd1	NP_001096355.1	GroEL	28..548	CDD:239460	392/519 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	749	1.000	Domainoid score	I97
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1626
Inparanoid	1	1.050	816	1.000	Inparanoid score	I466
OMA	1	1.010	-	-		QHG61846
OrthoDB	1	1.010	-	-		D183447at33208
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		otm48170
Panther	1	1.100	-	-	LDO	PTHR45633
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R572
SonicParanoid	1	1.000	-	-		X1504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110