DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42249 and Nt5e

DIOPT Version :9

Sequence 1:	NP_001259438.1	Gene:	CG42249 / 32043	FlyBaseID:	FBgn0259101	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_067587.2	Gene:	Nt5e / 58813	RGDID:	61956	Length:	576	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	179/557 - (32%)
Similarity:	302/557 - (54%)	Gaps:	28/557 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WSLVVVVAVMAVMCSSAEAADKEGFPVAIIHINDLHARFEATDTSGGTCDEGEECIGGYPRTVYT 74
            |.|:.:.|::.:..::      :.:.:.|:|.||:|:|.|.|......|.....|:||..|....
  Rat    11 WLLLALSALLPLWPTA------KSWELTILHTNDVHSRLEQTSDDSTKCLNASLCVGGVARLFTK 69

  Fly    75 VKRLLQEQAELNPIYINAGDSFQGTLWYNIGRWNVTQQLLNLLPADVMTLGNHEFDHGVEGVV-P 138
            |:::.:|  |.|.:.::|||.:|||:|:.:.:.......:|||..|.|.|||||||:||||:: |
  Rat    70 VQQIRKE--EPNVLLLDAGDQYQGTIWFTVYKGLEVAHFMNLLGYDAMALGNHEFDNGVEGLIDP 132

  Fly   139 FLETVDTNMLVANMDCAH--EPTMEGKYNKSMIIERSGRKIGVIGVILETTYDLANTG-KVIFRN 200
            .|..|...:|.||:....  .|.:.|.|....::...|..:|::|...:.|..|:|.| .::|.:
  Rat   133 LLRNVKFPILSANIKARGPLAPQISGLYLPYKVLSVGGEVVGIVGYTSKETPFLSNPGTNLVFED 197

  Fly   201 ESDTIREEAQLLKAQGANIIIVVSHCGYDVDQQIAANAGDWIDVIVGSHSHTFLYTGDPPGPHTP 265
            |...::.|...||....|.||.:.|.|:::|:.||..... :||:||.|::||||||:||....|
  Rat   198 EVTALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRG-VDVVVGGHTNTFLYTGNPPSKEVP 261

  Fly   266 SGDYPTEVIHSSGHRVLIVQASAYARYVGNLIVYFDDNGDVLDYEGDPLYMDQSVPEDDIVLQAM 330
            :|.||..|....|.:|.:|||.|:.:|:|.|.|.|||.|:|:...|:|:.::.::.||..:...:
  Rat   262 AGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKVEFDDKGNVVTSYGNPILLNSTIREDAAIKADI 326

  Fly   331 VPWQLEMKPIAERTVGQSRVNLQQS--QCSSGECNLGNFFTDAMLHAFVKDASSSSEESWSNVTI 393
            ..|::::...:.:.:|::.|.|..|  :|...|||:||...|||::   .:.....|..|::|::
  Rat   327 NQWRIKLDNYSTQELGRTIVYLNGSAQECRFRECNMGNLICDAMIN---NNLRHPDEMFWNHVSM 388

  Fly   394 ALTSTGTFRVPIPA---GNITYKQLFAMCPWQNRLVTLSLRGKHIVELLEHVVAPMNASSATPRS 455
            .:.:.|..|.||..   |.||::.|.|:.|:......:.|:|..:.:..||.|.....|     :
  Rat   389 CIVNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQS-----T 448

  Fly   456 SRFLQVSGLRIRYDLNAD--QRVFSVRVRCSKCLVPRYIPLDLEHKYRVVVMEYLANGKNGFSVI 518
            ..||||.|:.:.||::..  .||..::|.|:||.||.|.||:::..|:||:..||.||.:||.:|
  Rat   449 GEFLQVGGIHVVYDISRKPWDRVVQLKVLCTKCRVPIYEPLEMDKVYKVVLPSYLVNGGDGFQMI 513

  Fly   519 SENAEDPEFGPFDLDALMDYMNSTGPITTAIEQRIQF 555
            .:.....:.|..|:..:.:|::....|..|:|.||:|
  Rat   514 KDELLKHDSGDQDISVVSEYISKMKVIYPAVEGRIKF 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42249	NP_001259438.1	UshA	26..547	CDD:223808	171/531 (32%)
		MPP_CD73_N	36..316	CDD:277354	104/283 (37%)
		5_nucleotid_C	345..514	CDD:280945	57/175 (33%)
Nt5e	NP_067587.2	UshA	23..534	CDD:223808	169/527 (32%)
		MPP_CD73_N	31..312	CDD:277354	104/283 (37%)
		5_nucleotid_C	341..509	CDD:280945	57/175 (33%)
		Substrate binding. /evidence=ECO:0000250	502..508		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352765
Domainoid	1	1.000	162	1.000	Domainoid score	I3894
eggNOG	1	0.900	-	-		E1_COG0737
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52881
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101038
Panther	1	1.100	-	-	O	PTHR11575
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1114
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.720