DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42249 and NT5E

DIOPT Version :9

Sequence 1:	NP_001259438.1	Gene:	CG42249 / 32043	FlyBaseID:	FBgn0259101	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_002517.1	Gene:	NT5E / 4907	HGNCID:	8021	Length:	574	Species:	Homo sapiens

Alignment Length:	556	Identity:	181/556 - (32%)
Similarity:	302/556 - (54%)	Gaps:	29/556 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VVVAVMAVMCSSAEAADKEGFPVAIIHINDLHARFEATDTSGGTCDEGEECIGGYPRTVYTVKRL 78
            :::|:.||:..:|.|     :.:.|:|.||:|:|.|.|......|.....|:||..|....|:::
Human    12 LLLALGAVLWPAAGA-----WELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQI 71

  Fly    79 LQEQAELNPIYINAGDSFQGTLWYNIGRWNVTQQLLNLLPADVMTLGNHEFDHGVEGVV-PFLET 142
              .:||.|.:.::|||.:|||:|:.:.:.......:|.|..|.|.|||||||:||||:: |.|:.
Human    72 --RRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKE 134

  Fly   143 VDTNMLVANMDCAHEP---TMEGKYNKSMIIERSGRKIGVIGVILETTYDLANTG-KVIFRNESD 203
            ....:|.||:. |..|   .:.|.|....::......:|::|...:.|..|:|.| .::|.:|..
Human   135 AKFPILSANIK-AKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEIT 198

  Fly   204 TIREEAQLLKAQGANIIIVVSHCGYDVDQQIAANAGDWIDVIVGSHSHTFLYTGDPPGPHTPSGD 268
            .::.|...||....|.||.:.|.|:::|:.||..... :||:||.||:||||||:||....|:|.
Human   199 ALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRG-VDVVVGGHSNTFLYTGNPPSKEVPAGK 262

  Fly   269 YPTEVIHSSGHRVLIVQASAYARYVGNLIVYFDDNGDVLDYEGDPLYMDQSVPEDDIVLQAMVPW 333
            ||..|....|.:|.:|||.|:.:|:|.|.:.||:.|:|:...|:|:.::.|:|||..:...:..|
Human   263 YPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKW 327

  Fly   334 QLEMKPIAERTVGQSRVNLQQS--QCSSGECNLGNFFTDAMLHAFVKDASSSSEESWSNVTIALT 396
            ::::...:.:.:|::.|.|..|  .|...|||:||...|||::   .:...:.|..|::|::.:.
Human   328 RIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMIN---NNLRHTDEMFWNHVSMCIL 389

  Fly   397 STGTFRVPIPA---GNITYKQLFAMCPWQNRLVTLSLRGKHIVELLEHVVAPMNASSATPRSSRF 458
            :.|..|.||..   |.||::.|.|:.|:......:.|:|..:.:..||.|.....|     :..|
Human   390 NGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQS-----TGEF 449

  Fly   459 LQVSGLRIRYDLN--ADQRVFSVRVRCSKCLVPRYIPLDLEHKYRVVVMEYLANGKNGFSVISEN 521
            |||.|:.:.|||:  ...||..:.|.|:||.||.|.||.::..|:|::..:||||.:||.:|.:.
Human   450 LQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDE 514

  Fly   522 AEDPEFGPFDLDALMDYMNSTGPITTAIEQRIQFVT 557
            ....:.|..|::.:..|::....|..|:|.||:|.|
Human   515 LLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFST 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42249	NP_001259438.1	UshA	26..547	CDD:223808	172/532 (32%)
		MPP_CD73_N	36..316	CDD:277354	101/284 (36%)
		5_nucleotid_C	345..514	CDD:280945	57/175 (33%)
NT5E	NP_002517.1	UshA	11..532	CDD:223808	173/536 (32%)
		MPP_CD73_N	29..310	CDD:277354	101/284 (36%)
		5_nucleotid_C	339..507	CDD:280945	57/175 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158759
Domainoid	1	1.000	160	1.000	Domainoid score	I4045
eggNOG	1	0.900	-	-		E1_COG0737
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52881
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101038
Panther	1	1.100	-	-	O	PTHR11575
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.720