DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42249 and nt5e

DIOPT Version :9

Sequence 1:	NP_001259438.1	Gene:	CG42249 / 32043	FlyBaseID:	FBgn0259101	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_957226.1	Gene:	nt5e / 393906	ZFINID:	ZDB-GENE-040426-1261	Length:	571	Species:	Danio rerio

Alignment Length:	559	Identity:	197/559 - (35%)
Similarity:	300/559 - (53%)	Gaps:	34/559 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SLVVVVAVMAVMCSSAEAADKEGFPVAIIHINDLHARFEATDTSGGTCDEGEECIGGYPRTVYTV 75
            |.::::.:...:|.||:      |.:.::|.||:|||.|.|:...|.|.: ..|..|..|....:
Zfish     8 SALLLLFIHCQLCWSAD------FQLTLLHTNDVHARVEETNKDSGKCSK-PPCFAGVSRRSTKI 65

  Fly    76 KRLLQEQAELNPIYINAGDSFQGTLWYNIGRWNVTQQLLNLLPADVMTLGNHEFDHGVEGVV-PF 139
            |.:  ...|.|.:.::|||.||||:|:|..:.......:|.|..|.|.|||||||:||:|:: ||
Zfish    66 KEI--RSKEKNVLLLDAGDQFQGTVWFNYYKGAEAAYFMNQLKYDAMALGNHEFDNGVDGLLKPF 128

  Fly   140 LETVDTNMLVANM--DCAHEPTMEGKYNKSMIIERSGRKIGVIGVILETTYDLANTGKVI-FRNE 201
            |:.|:..:|.||:  |....|.:.|.|....|......|:||:|.....|..|:..|..: |.:|
Zfish   129 LQEVNCTVLSANIKADETLAPRISGYYFPYKIFTLGSEKVGVVGYTSAETPALSLPGPHLKFEDE 193

  Fly   202 SDTIREEAQLLKAQGANIIIVVSHCGYDVDQQIAANAGDWIDVIVGSHSHTFLYTGDPPGPHTPS 266
            ...::.:...|...|.|.||.:.|.|:.:||.||... ..:||::|.|::|||||||||....|:
Zfish   194 ITALQPQVDKLLTLGVNKIIALGHSGFLMDQMIAKKV-QGVDVVIGGHTNTFLYTGDPPSTEVPA 257

  Fly   267 GDYPTEVIHSSGHRVLIVQASAYARYVGNLIVYFDDNGDVLDYEGDPLYMDQSV-PEDDIVLQAM 330
            |.||..|....|.:|.:|||.|:.:|:|.|.|.||.||:||:..|:|:.::.|| |:.||  ||.
Zfish   258 GPYPLMVKSDDGRQVPVVQAYAFGKYLGFLKVTFDANGNVLESTGNPILLNSSVEPDPDI--QAK 320

  Fly   331 V-PWQLEMKPIAERTVGQSRVNLQQS--QCSSGECNLGNFFTDAMLHAFVKDASSSSEESWSNVT 392
            | .|::.:...:.:.|||:.|.|..:  :|...||||||...|||:|..:|.|   .|..|::|:
Zfish   321 VDSWRMNLANYSSQQVGQTLVFLNGTFEECRFRECNLGNLICDAMVHHNIKYA---DELQWNHVS 382

  Fly   393 IALTSTGTFRVPIPA----GNITYKQLFAMCPWQNRLVTLSLRGKHIVELLEHVVAPMNASSATP 453
            ..:.:.|..|.||..    |:||.:.|.|:.|:......:.|.|..::|..||.|.....:
Zfish   383 SCILNGGGIRGPIDERNRNGSITMEDLIAVLPFGGTFDLVQLNGSTLLEAFEHSVRRHGGN---- 443

  Fly   454 RSSRFLQVSGLRIRYDLN--ADQRVFSVRVRCSKCLVPRYIPLDLEHKYRVVVMEYLANGKNGFS 516
             :..||||||.::.|||:  ...||.||:|.|::|.||.|.||.....|:||:..||.:|.:||:
Zfish   444 -TGEFLQVSGFQVVYDLSKAPGSRVKSVKVLCTQCRVPHYEPLVPNKVYKVVLPSYLVDGGDGFT 507

  Fly   517 VISENAEDPEFGPFDLDALMDYMNSTGPITTAIEQRIQF 555
            :|.|.....:.|..|:..:..|::....:..|:|.|.||
Zfish   508 MIKEKKLKHDSGDLDISVVAGYISERKRVHPAVEGRFQF 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42249	NP_001259438.1	UshA	26..547	CDD:223808	189/534 (35%)
		MPP_CD73_N	36..316	CDD:277354	107/283 (38%)
		5_nucleotid_C	345..514	CDD:280945	64/176 (36%)
nt5e	NP_957226.1	UshA	23..525	CDD:223808	188/521 (36%)
		MPP_CD73_N	27..307	CDD:277354	107/283 (38%)
		5_nucleotid_C	335..505	CDD:280945	64/177 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0737
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52881
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101038
Panther	1	1.100	-	-	O	PTHR11575
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.760