DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42249 and AgaP_AGAP001601

DIOPT Version :9

Sequence 1:	NP_001259438.1	Gene:	CG42249 / 32043	FlyBaseID:	FBgn0259101	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	XP_321497.2	Gene:	AgaP_AGAP001601 / 3290489	VectorBaseID:	AGAP001601	Length:	566	Species:	Anopheles gambiae

Alignment Length:	562	Identity:	250/562 - (44%)
Similarity:	356/562 - (63%)	Gaps:	28/562 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VVVVAVMAVMCSS-------------AEAADKEGFPVAIIHINDLHARFEATDTSGGTC--DEGE 62
            :.|.||..|.|::             ||.:|...:|:.|||:||.|||||.|:|....|  ||||
Mosquito    14 LTVTAVCGVCCAAASEQGVLISKTWRAEKSDDPLYPLTIIHLNDFHARFEETNTVSTRCKPDEGE 78

  Fly    63 ECIGGYPRTVYTVKRLLQEQAELNPIYINAGDSFQGTLWYNIGRWNVTQQLLNLLPADVMTLGNH 127
            .|||||.|.|..||.|.||.|:.||||:|||||||||:||.:.|||||...|||||||.||||||
Mosquito    79 RCIGGYARVVSRVKSLQQEYADRNPIYLNAGDSFQGTIWYTLLRWNVTAYFLNLLPADAMTLGNH 143

  Fly   128 EFDHGVEGVVPFLETVDTNMLVANMDCAHEPTMEGKYNKSMIIERSGRKIGVIGVILETTYDLAN 192
            ||||||||:||||..:|:.|||||:|...|||::|||.:|:::||.|||||:||||...|..|:.
Mosquito   144 EFDHGVEGLVPFLGAIDSPMLVANIDDREEPTLQGKYQRSVVLERGGRKIGIIGVIHHATDTLSM 208

  Fly   193 TGKVIFRNESDTIREEAQLLKAQGANIIIVVSHCGYDVDQQIAANAGDWIDVIVGSHSHTFLYTG 257
            |.:|.|.:|...|.:||..||..|.:||:|:||||:.:|||||....| :||:||.||||.|:||
Mosquito   209 TDRVRFLDEVQCINQEATALKQLGVDIIVVLSHCGFTIDQQIARECPD-VDVVVGGHSHTLLHTG 272

  Fly   258 D-PPGPHTPSGDYPTEVIHSSGHRVLIVQASAYARYVGNLIVYFDDNGDVLDYEGDPLYMDQSVP 321
            . ...|..|:|.||..|..::|.|||||||.::.:|:|:|:||||:.|:.:.:||:..|:|:|.|
Mosquito   273 TVADWPDVPAGSYPFVVEQAAGRRVLIVQAGSFTKYLGHLVVYFDERGEAVRWEGNTEYLDESFP 337

  Fly   322 EDDIVLQAMVPWQLEMKPIAERTVGQSRVNLQQSQCSSGECNLGNFFTDAMLHAFVKDASSSSEE 386
            :|:.:.:.:|||:.::..:|.|.||.|||.|.:..|.:||||.|:|..||.:..:|  ....:|.
Mosquito   338 KDEQIERELVPWRTQVDALAVRPVGVSRVFLSKPACRTGECNFGSFVADAFVDYYV--GRGEAEH 400

  Fly   387 SWSNVTIALTSTGTFRVPIPAGNITYKQLFAMCPWQNRLVTLSLRGKHIVELLEHVVAPMNASSA 451
            .|:...|.:|:.|..|..:..|.:||:.|....|::|.:.|..|||:::::.||:       |::
Mosquito   401 EWTYAAIGITNDGGLRTSLAPGTLTYEDLVTAIPYENTVDTFELRGQYLLDALEY-------SAS 458

  Fly   452 TPRSSRFLQVSGLRIRYDLN--ADQRVFSVRVRCSKCLVPRYIPLDLEHKYRVVVMEYLANGKNG 514
            ...::..||.:|||:.::|.  |.|||..|.|||..|.:|||.|||:...||:.:..::.:|.||
Mosquito   459 RYDTADVLQFAGLRVVFNLTRPALQRVQRVDVRCRVCRIPRYEPLDVNATYRIAIAAWIGSGGNG 523

  Fly   515 FSVISENAEDPEFGPFDLDALMDYMNSTGPITTAIEQRIQFV 556
            :::..::..:...||.|:|....|:....||....:.|:.||
Mosquito   524 YTMFGQHRTNVRVGPLDIDVFERYVAKMSPIMQGTDGRMVFV 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42249	NP_001259438.1	UshA	26..547	CDD:223808	242/525 (46%)
		MPP_CD73_N	36..316	CDD:277354	160/282 (57%)
		5_nucleotid_C	345..514	CDD:280945	59/170 (35%)
AgaP_AGAP001601	XP_321497.2	UshA	31..566	CDD:223808	245/545 (45%)
		MPP_CD73_N	50..332	CDD:277354	160/282 (57%)
		5_nucleotid_C	360..523	CDD:280945	59/171 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	121	1.000	Domainoid score	I11247
eggNOG	1	0.900	-	-		E1_COG0737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52881
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	1	1.000	-	-		otm50819
Panther	1	1.100	-	-	O	PTHR11575
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1114
TreeFam	1	0.960	-	-
	10	9.890