DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42249 and AgaP_AGAP007139

DIOPT Version :9

Sequence 1:	NP_001259438.1	Gene:	CG42249 / 32043	FlyBaseID:	FBgn0259101	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	XP_565056.3	Gene:	AgaP_AGAP007139 / 3290312	VectorBaseID:	AGAP007139	Length:	558	Species:	Anopheles gambiae

Alignment Length:	532	Identity:	244/532 - (45%)
Similarity:	352/532 - (66%)	Gaps:	16/532 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FPVAIIHINDLHARFEATDTSGGTCD-----EGEECIGGYPRTVYTVKRLLQEQAELNPIYINAG 93
            ||::::||||:||.:|..||:..|||     ..|:|:|||.|||..|::||||:.  ||:|:|.|
Mosquito    33 FPLSLVHINDIHAHWEEIDTASVTCDPKRDGAAEQCLGGYARTVTIVRQLLQERP--NPVYLNIG 95

  Fly    94 DSFQGTLWYNIGRWNVTQQLLNLLPADVMTLGNHEFDHGVEGVVPFLETVDTNMLVANMDCAHEP 158
            |:|||||||||.|||.|...|||||||.:|:||||||.|:.|||||||.:.:.:|:.|:|.:.||
Mosquito    96 DNFQGTLWYNIHRWNATAFFLNLLPADAVTVGNHEFDDGIAGVVPFLEAIQSPVLLVNVDNSKEP 160

  Fly   159 TMEGKYNKSMIIERSGRKIGVIGVILETTYDLANTGKVIFRNESDTIREEAQLLKAQGANIIIVV 223
            :. .|:..||::||:|||||:|||||.|||::|:||.::|.:|::|:|.||..|.|:|.:|::|:
Mosquito   161 SF-SKFRPSMVLERAGRKIGLIGVILRTTYNMADTGALVFEDEAETVRLEADRLAAEGVDIVVVL 224

  Fly   224 SHCGYDVDQQIAANAGDWIDVIVGSHSHTFLYTG-DPPGPHTPSGDYPTEVIHSSGHRVLIVQAS 287
            ||||.|||..||||||..:|:|||.|||:|||:| :...|.||:.:|||.|....||||||||||
Mosquito   225 SHCGLDVDHIIAANAGPNVDIIVGGHSHSFLYSGQNDKIPMTPASEYPTVVNQPDGHRVLIVQAS 289

  Fly   288 AYARYVGNLIVYFDDNGDVLDYEGDPLYMDQSVPEDDIVLQAMVPWQLEMKPIAERTVGQSRVNL 352
            ||.:.||::::||||.|.|..:||:|:|:...:..|..||:|:.||::.:..:.|||:|.:.|:|
Mosquito   290 AYTKLVGDIVLYFDDQGIVQHWEGNPIYLSNDIVPDAEVLEAIAPWKVAIDAVGERTIGATAVDL 354

  Fly   353 QQSQCSSGECNLGNFFTDAMLHAFVKDASSSSEESWSNVTIALTSTGTFRVPIPAGNITYKQLFA 417
            .:..|:.|||.|||...|:|:.|||..|   .|.||:..:||..:.|..|..:..|:|::|.|..
Mosquito   355 LKPPCNFGECVLGNLIADSMVEAFVPMA---EEGSWTYASIAAIAVGRIRQSLVPGDISFKHLIE 416

  Fly   418 MCPWQNRLVTLSLRGKHIVELLEHVVAPMNASSATPRSSRFLQVSGLRIRYDLN--ADQRVFSVR 480
            :.|::|:||.|.|||..:|.|||| .|.::.......:...:.|||||:.|::.  ...||.||.
Mosquito   417 VLPFENKLVCLELRGFQLVGLLEH-GAELSWDEHRFNAKNLMHVSGLRVVYNVTNPIGHRVLSVE 480

  Fly   481 VRCSKCLVPRYIPLDLEHKYRVVVMEYLANGKNGFSVISENAEDPEFGPF-DLDALMDYMNSTGP 544
            ..|..|.:|.|.|:::...||||.:.|||.|.:||.:......:....|. |:.|..:|:....|
Mosquito   481 ALCQDCSMPSYAPVEMFKMYRVVTVSYLAEGGDGFEIFPRYGRNRVVAPMDDVQAFEEYVKPRSP 545

  Fly   545 ITTAIEQRIQFV 556
            :...:|:|||.:
Mosquito   546 VAPVLEERIQIL 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42249	NP_001259438.1	UshA	26..547	CDD:223808	240/521 (46%)
		MPP_CD73_N	36..316	CDD:277354	157/285 (55%)
		5_nucleotid_C	345..514	CDD:280945	64/170 (38%)
AgaP_AGAP007139	XP_565056.3	UshA	8..548	CDD:223808	240/521 (46%)
		MPP_CD73_N	35..318	CDD:277354	157/285 (55%)
		5_nucleotid_C	347..514	CDD:280945	64/170 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0737
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80551
Inparanoid	1	1.050	505	1.000	Inparanoid score	I3004
OMA	1	1.010	-	-		QHG52881
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	1	1.000	-	-		otm50819
Panther	1	1.100	-	-	O	PTHR11575
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1114
TreeFam	1	0.960	-	-
	12	11.940