DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42249 and Nt5e

DIOPT Version :9

Sequence 1:	NP_001259438.1	Gene:	CG42249 / 32043	FlyBaseID:	FBgn0259101	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_035981.1	Gene:	Nt5e / 23959	MGIID:	99782	Length:	576	Species:	Mus musculus

Alignment Length:	559	Identity:	181/559 - (32%)
Similarity:	304/559 - (54%)	Gaps:	32/559 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WSLVVVVAVMAVMCSSAEAADKEGFPVAIIHINDLHARFEATDTSGGTCDEGEECIGGYPRTVYT 74
            |.|:.:.|::....:::      .:.:.|:|.||:|:|.|.|......|.....|:||..|....
Mouse    11 WLLLALSALLPQWPAAS------AWELTILHTNDVHSRLEQTSDDSTKCLNASLCVGGVARLFTK 69

  Fly    75 VKRLLQEQAELNPIYINAGDSFQGTLWYNIGRWNVTQQLLNLLPADVMTLGNHEFDHGVEGVV-P 138
            |:::.:|  |.|.::::|||.:|||:|:.:.:.......:|:|..|.|.|||||||:||||:: |
Mouse    70 VQQIRKE--EPNVLFLDAGDQYQGTIWFTVYKGLEVAHFMNILGYDAMALGNHEFDNGVEGLIDP 132

  Fly   139 FLETVDTNMLVANMDC----AHEPTMEGKYNKSMIIERSGRKIGVIGVILETTYDLANTG-KVIF 198
            .|..|...:|.||:..    ||:  :.|.:..|.::...|..:|::|...:.|..|:|.| .::|
Mouse   133 LLRNVKFPILSANIKARGPLAHQ--ISGLFLPSKVLSVGGEVVGIVGYTSKETPFLSNPGTNLVF 195

  Fly   199 RNESDTIREEAQLLKAQGANIIIVVSHCGYDVDQQIAANAGDWIDVIVGSHSHTFLYTGDPPGPH 263
            .:|...::.|...||....|.||.:.|.|:::|:.||..... :|::||.||:||||||:||...
Mouse   196 EDEISALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRG-VDIVVGGHSNTFLYTGNPPSKE 259

  Fly   264 TPSGDYPTEVIHSSGHRVLIVQASAYARYVGNLIVYFDDNGDVLDYEGDPLYMDQSVPEDDIVLQ 328
            .|:|.||..|....|.:|.:|||.|:.:|:|.|.|.|||.|:|:...|:|:.::.|:|||..:..
Mouse   260 VPAGKYPFIVTADDGRQVPVVQAYAFGKYLGYLKVEFDDKGNVITSYGNPILLNSSIPEDATIKA 324

  Fly   329 AMVPWQLEMKPIAERTVGQSRVNLQQS--QCSSGECNLGNFFTDAMLHAFVKDASSSSEESWSNV 391
            .:..|::::...:.:.:|::.|.|..|  .|...|||:||...|||::   .:.....|..|::|
Mouse   325 DINQWRIKLDNYSTQELGRTIVYLDGSTQTCRFRECNMGNLICDAMIN---NNLRHPDEMFWNHV 386

  Fly   392 TIALTSTGTFRVPIPA---GNITYKQLFAMCPWQNRLVTLSLRGKHIVELLEHVVAPMNASSATP 453
            ::.:.:.|..|.||..   |.||::.|.|:.|:......:.|:|..:.:..||.|.....|
Mouse   387 SMCIVNGGGIRSPIDEKNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQS---- 447

  Fly   454 RSSRFLQVSGLRIRYDLNAD--QRVFSVRVRCSKCLVPRYIPLDLEHKYRVVVMEYLANGKNGFS 516
             :..||||.|:.:.||:|..  .||..:.|.|:||.||.|.||:::..|:|.:..|||||.:||.
Mouse   448 -TGEFLQVGGIHVVYDINRKPWNRVVQLEVLCTKCRVPIYEPLEMDKVYKVTLPSYLANGGDGFQ 511

  Fly   517 VISENAEDPEFGPFDLDALMDYMNSTGPITTAIEQRIQF 555
            :|.:.....:.|..|:..:.:|::....:..|:|.||:|
Mouse   512 MIKDELLKHDSGDQDISVVSEYISKMKVVYPAVEGRIKF 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42249	NP_001259438.1	UshA	26..547	CDD:223808	173/533 (32%)
		MPP_CD73_N	36..316	CDD:277354	104/285 (36%)
		5_nucleotid_C	345..514	CDD:280945	58/175 (33%)
Nt5e	NP_035981.1	UshA	21..534	CDD:223808	172/531 (32%)
		MPP_CD73_N	31..312	CDD:277354	104/285 (36%)
		5_nucleotid_C	354..509	CDD:280945	54/162 (33%)
		Substrate binding. /evidence=ECO:0000250	502..508		5/5 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0737
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52881
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101038
Panther	1	1.100	-	-	O	PTHR11575
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.710