DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42249 and AgaP_AGAP011971

DIOPT Version :9

Sequence 1:	NP_001259438.1	Gene:	CG42249 / 32043	FlyBaseID:	FBgn0259101	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	XP_320561.2	Gene:	AgaP_AGAP011971 / 1280699	VectorBaseID:	AGAP011971	Length:	558	Species:	Anopheles gambiae

Alignment Length:	561	Identity:	214/561 - (38%)
Similarity:	316/561 - (56%)	Gaps:	66/561 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LVVVVAVMAVM--CSSAE--AADK----EGFPVAIIHINDLHARFEATDTSGGTC---DEGEECI 65
            |:..:|.:|.|  ||:.:  ..|:    |.||:.|||:|||||||..|......|   :||:.||
Mosquito     7 LIGTLAWVASMQRCSATDHLPPDQRQLAELFPLTIIHMNDLHARFAETSERSSKCKAAEEGDTCI 71

  Fly    66 GGYPRTVYTVKRLLQEQAELNPIYINAGDSFQGTLWYNIGRWNVTQQLLNLLPADVMTLGNHEFD 130
            .|..|..:||:.|  .:...|.::.|.||:||||:|||..||.|..:.:.||..|.|||||||||
Mosquito    72 AGIARVFHTVQEL--RKRHRNALFFNVGDNFQGTIWYNYHRWRVVARFIKLLHPDAMTLGNHEFD 134

  Fly   131 HGVEGVVPFL--------ETVDTNMLVANMDCAHEPTMEGKYNKSMIIERSGRKIGVIGVILETT 187
            .|::|:.|:|        :||.||::.:.......|       :|:.|:|.||.||:||||.:.|
Mosquito   135 DGLKGLRPYLSALAKKDIQTVATNLIRSTDPFPALP-------RSVTIKRKGRSIGIIGVIADKT 192

  Fly   188 YDLANTGKVIFRNESDTIREEAQLLKAQGANIIIVVSHCGYDVDQQIAANAGDWIDVIVGSHSHT 252
            ::|:||..:.|.:....:||||..||.:..|||:|:||||.:||::||..|||.:|||:|.|||:
Mosquito   193 HELSNTESITFSDSVAAVREEAAALKKRDVNIILVLSHCGLEVDKRIALEAGDDVDVIIGGHSHS 257

  Fly   253 FLYTGDPPGPH----TPSGDYPTEVIHSSGHRVLIVQASAYARYVGNLIVYFDDNGDVLDYEGDP 313
            ||:......||    |..||||..|.:::|.::|||||.||.:|||.|..|||..|:|..:||.|
Mosquito   258 FLFPNASSKPHNQQDTILGDYPVVVSNANGRKILIVQAYAYGKYVGRLTAYFDAQGEVQHWEGFP 322

  Fly   314 LYMDQSVPEDDIVLQAMVPWQLEMKPIAERTVGQSRVNLQQSQCSSGECNLGNFFTDAMLHAFVK 378
            :|:..|||:..:.|:.:.|::.:::......:.|:.|:|.|:.|..|||:||....||:
Mosquito   323 VYLSNSVPQSPVALRILAPYRRQVEAYGATKIAQTTVDLVQATCRLGECSLGCLVADAI------ 381

  Fly   379 DASSSSEESWSNVT---IALTSTGTFRVPIPAGNITYKQLFAMCPWQNRLVTLSLRGKHIVELLE 440
                  .:.::|.|   :|:.:.|.||.|||.|:||.::.....|:.|.:..|:|||..:.:|:|
Mosquito   382 ------ADYYTNHTFHPVAIINAGNFRSPIPKGDITNEEAIGASPFSNTVDLLTLRGDALWQLVE 440

  Fly   441 H-----VVAPMNASSATPRSSRFLQVSGLRIRYDLNADQ--RVFSVRVRCSKCLVPRYIPLDLEH 498
            |     .|..:|.:          ||:|||:..||:...  ||.|:.||.....| .|.||:...
Mosquito   441 HSLVWDSVKRLNVA----------QVAGLRVVADLDRAPYGRVLSIDVRNLNDGV-SYEPLNRTA 494

  Fly   499 KYRVVVMEYLANGKNGFSVISENAEDPEFGPFDLDALMDYM 539
            .||||.|.::|.||:||....|.:| .:.||.|.|..:.|:
Mosquito   495 NYRVVTMSFIATGKDGFRWALERSE-RQIGPLDSDTFIQYL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42249	NP_001259438.1	UshA	26..547	CDD:223808	208/545 (38%)
		MPP_CD73_N	36..316	CDD:277354	130/294 (44%)
		5_nucleotid_C	345..514	CDD:280945	59/178 (33%)
AgaP_AGAP011971	XP_320561.2	UshA	3..538	CDD:223808	214/561 (38%)
		MPP_CD73_N	39..325	CDD:277354	130/294 (44%)
		5_nucleotid_C	353..510	CDD:280945	59/179 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52881
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11575
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1114
TreeFam	1	0.960	-	-
	8	7.890