DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42249 and nt5e

DIOPT Version :9

Sequence 1:	NP_001259438.1	Gene:	CG42249 / 32043	FlyBaseID:	FBgn0259101	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	XP_002933973.1	Gene:	nt5e / 100489347	XenbaseID:	XB-GENE-984211	Length:	578	Species:	Xenopus tropicalis

Alignment Length:	560	Identity:	180/560 - (32%)
Similarity:	301/560 - (53%)	Gaps:	31/560 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTWSLVVVVAVMAVMCSSAEAADKEGFPVAIIHINDLHARFEATDTSGGTCDEGEECIGGYPRTV 72
            |.|.|        ::||...:.......:.|:|.||:|||.|.|:...|.|.:.::|.||..|..
Frog     5 LVWLL--------LLCSQRCSPSAATLQLTILHTNDVHARVEQTNRDSGKCGDPQDCYGGVARRF 61

  Fly    73 YTVKRLLQEQAELNPIYINAGDSFQGTLWYNIGRWNVTQQLLNLLPADVMTLGNHEFDHGVEGVV 137
            ..::.:  .....:.:.::|||.:|||:|:|..:.:.....:|.|..|.|.|||||||:||.|::
Frog    62 AKIEEI--RSTHRHVLLLDAGDQYQGTIWFNYYKGHEAAYFMNYLKYDAMALGNHEFDNGVSGLL 124

  Fly   138 -PFLETVDTNMLVANM--DCAHEPTMEGKYNKSMIIERSGRKIGVIGVILETTYDLANTG-KVIF 198
             |||:.|...:|.||:  |....|.:.|.|....|:|....||||||.....|..|:|:| .::|
Frog   125 SPFLQEVKFPILSANIKSDKQLAPNITGYYLPYKILEVGTEKIGVIGYSSRETPVLSNSGPHLVF 189

  Fly   199 RNESDTIREEAQLLKAQGANIIIVVSHCGYDVDQQIAANAGDWIDVIVGSHSHTFLYTGDPPGPH 263
            .:|...::.:...|...|.|.||.:.|.|::.|:.||... ..|||:||.|::||||||.||...
Frog   190 EDEVLALQPQVDKLLTLGVNKIIALGHSGFETDKLIAQKV-KGIDVVVGGHTNTFLYTGPPPSND 253

  Fly   264 TPSGDYPTEVIHSSGHRVLIVQASAYARYVGNLIVYFDDNGDVLDYEGDPLYMDQSVPEDDIVLQ 328
            .|.|:||..|:...|..|.:|||.|:.:|:|.|.:.||:.|.|:...|:|:.:|:|:|||..:|.
Frog   254 VPVGEYPFSVMSDDGRSVPVVQAYAFGKYLGYLNITFDEQGTVVHSFGNPILLDRSIPEDATLLG 318

  Fly   329 AMVPWQLEMKPIAERTVGQSRVNLQQS--QCSSGECNLGNFFTDAMLHAFVKDASSSSEESWSNV 391
            .:..|:..::..:.:.:|::.|.|..|  :|.:.|||:||...|||:...::   ...|..|::|
Frog   319 EVNQWKEAIRNYSSQPIGKTLVYLNGSSLECRNRECNMGNLICDAMIDNNIR---HPDEVRWNHV 380

  Fly   392 TIALTSTGTFRVPIPA----GNITYKQLFAMCPWQNRLVTLSLRGKHIVELLEHVVAPMNASSAT 452
            ::.:.:.|..|..|..    |.||.:.|.::.|::.....:.::|..:....||.|....:.
Frog   381 SLCILNGGGIRAAIDERISNGTITTEDLISVLPFEGTFDLIEIKGSTLKSAFEHSVHRYGSG--- 442

  Fly   453 PRSSRFLQVSGLRIRYDL--NADQRVFSVRVRCSKCLVPRYIPLDLEHKYRVVVMEYLANGKNGF 515
              :..||||.|:::.:|.  :..|||..:.|.|::|.||:|:|::::..|:||:..|:|.|.:||
Frog   443 --TGEFLQVGGIKVVFDTEKSPGQRVVKLEVICTECRVPKYVPVEMDKIYKVVLPSYIAAGGDGF 505

  Fly   516 SVISENAEDPEFGPFDLDALMDYMNSTGPITTAIEQRIQF 555
            |::.:.:...:.|..||..:.:|:.....:..|:|.||.|
Frog   506 SMLKDESLKHDSGDTDLTVVSNYIAQRQRVYPAVEGRITF 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42249	NP_001259438.1	UshA	26..547	CDD:223808	170/532 (32%)
		MPP_CD73_N	36..316	CDD:277354	106/283 (37%)
		5_nucleotid_C	345..514	CDD:280945	50/176 (28%)
nt5e	XP_002933973.1	MPP_CD73_N	25..306	CDD:277354	106/283 (37%)
nt5e	XP_002933973.1	5_nucleotid_C	334..510	CDD:376948	53/183 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010