DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2061 and LANCL3

DIOPT Version :9

Sequence 1:	NP_001259437.1	Gene:	CG2061 / 32042	FlyBaseID:	FBgn0027498	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_001163802.1	Gene:	LANCL3 / 347404	HGNCID:	24767	Length:	420	Species:	Homo sapiens

Alignment Length:	439	Identity:	170/439 - (38%)
Similarity:	243/439 - (55%)	Gaps:	46/439 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RRYLKNPFPDFAGGENTPFASDEEHIKNLICTYVDAILEHCHPNSDDEDNR----------GDLY 57
            :|...|.|.|:.|  :......||.:..|:...::.||:...|.....:.|          |.||
Human     4 KRCFANRFDDYQG--SLLAGQCEEAVAPLVTATIERILQELPPLGGGAEARGATAGASACQGGLY 66

  Fly    58 VGNAGIAFMFWKLNSCEQTRDLYPALDHAAS-FIRNAK------VNANRYKKRSAE-RYSFLCGN 114
            .|.||:|:|.:.::..       |....|.. ::|:||      ..|..:.:..|: |.:||.|.
Human    67 GGVAGVAYMLYHVSQS-------PLFATARERYLRSAKRLIDACARAEEWGEPDADTRAAFLLGG 124

  Fly   115 AGIYAVSAAISQALKETEELSDDLANFKSGIPCSKEFMHTKYGCDEVLVGRAGYLSGCYWLNDVL 179
            ||:|||:..:..||..::.: ..|..|::...........:.|.||:.|||||||.....|...|
Human   125 AGVYAVATLVYHALGRSDYV-QPLGKFRALCAVCAPVSFLECGSDELFVGRAGYLCAALVLKQKL 188

  Fly   180 PEKKITDDDLVSICQLIVTSGREYSKQNNSPCPLMYQYHGTEYLGAAHGLCAILHMLLD-----S 239
            .::.:|...:.||||.|:.||::|:.:...|.||||.|:|||||||||||.:||.|||.     .
Human   189 AQEVLTPAQIKSICQAILDSGKQYAIKKRKPFPLMYSYYGTEYLGAAHGLSSILQMLLSYHEHLK 253

  Fly   240 PWFRTLPISAPAAELRDIKRSIDFFLELQDSDGNFPVALEDLRSGRDKRLVHWCHGAPGAVYVLA 304
            |..|.|           :.:|:||.:| |:.:.|:|..|.:... |:..||||||||||..|:.|
Human   254 PSDREL-----------VWQSVDFLME-QEQNCNWPPELGETIE-RENELVHWCHGAPGIAYLFA 305

  Fly   305 KAYLIFKEEKYLASLRRCADMVWKKGFLRKGPGICHGVAGNGYVFLLLFRLTNEMRYLYRAHKFM 369
            ||||:.|:.:||.:..||.::.|:||.|:|||||||||||:.||||||:|||...:|:|||.:|.
Human   306 KAYLVSKKPQYLDTCIRCGELTWQKGLLKKGPGICHGVAGSAYVFLLLYRLTGNSKYIYRAQRFA 370

  Fly   370 ELLTNAEFKLRARTPDRPHSLYEGVAGTVCYLVDLLEPEQAYFPFMDVF 418
            :.|...|||..:|..:..:|||||.:||||:|:|||:|.||.||...||
Human   371 QFLFTEEFKAGSRVLESIYSLYEGFSGTVCFLIDLLQPNQAEFPLFSVF 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2061	NP_001259437.1	euk_LANCL	56..413	CDD:271202	153/369 (41%)
LANCL3	NP_001163802.1	euk_LANCL	65..414	CDD:271202	153/369 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141351
Domainoid	1	1.000	276	1.000	Domainoid score	I1755
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13421
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2848
Isobase	1	0.950	-	0	Normalized mean entropy	S6618
OMA	1	1.010	-	-		QHG49990
OrthoDB	1	1.010	-	-		D316897at33208
OrthoFinder	1	1.000	-	-		FOG0007580
OrthoInspector	1	1.000	-	-		oto90437
orthoMCL	1	0.900	-	-		OOG6_101476
Panther	1	1.100	-	-	LDO	PTHR12736
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8767
SonicParanoid	1	1.000	-	-		X807
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.890