DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and Fgfr3

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:XP_006251454.1 Gene:Fgfr3 / 84489 RGDID:620714 Length:803 Species:Rattus norvegicus


Alignment Length:859 Identity:207/859 - (24%)
Similarity:340/859 - (39%) Gaps:215/859 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1718 PGVRYQLNLTLAKEPGSEEHDHGMEPLGQWLLGAGESLNLTDLLPF------TRYRVSGILSSFY 1776
            ||...::....|:.||.|....     .|...|:|:::.|:...|.      |.:...|:     
  Rat    23 PGPEQRVGRRAAEVPGPEPSQQ-----EQVAFGSGDTVELSCHPPGGAPTGPTLWAKDGV----- 77

  Fly  1777 QKKLALPTLVLAPLELLTASATP------SPPRNFSVRVLSPRELEVS----------------- 1818
             ..:|...:::.|..|...:||.      |..:..:.|||....:.|:                 
  Rat    78 -GLVASHRILVGPQRLQVLNATHEDAGVYSCQQRLTRRVLCHFSVRVTDAPSSGDDEDGEDVAED 141

  Fly  1819 -----WLPPEQLRSESVYY----TLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPGSG 1874
                 |..||::..:.:..    |:.::....| |......|..:.:  |..|.||:.|||  ..
  Rat   142 TGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG-NPTPSISWLKNGK--EFRGEHRIGGIK--LR 201

  Fly  1875 YSLW--VQAHATPTKSNSSERLHVRSFAELPE---LQLLELGPYSLSLTWAGTPDPLGSLQLECR 1934
            :..|  |.....|:...:...:....|..:.:   |.:||..|:. .:..||.|           
  Rat   202 HQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHR-PILQAGLP----------- 254

  Fly  1935 SSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKP 1999
                       .|.|.::...::    :.|:                   ||     :.:||...
  Rat   255 -----------ANQTAVLGSDVE----FHCK-------------------VY-----SDAQPHIQ 280

  Fly  2000 QLEHIAEEVFRVTWTAARGNGAPIALY-------NLEALQARSDIRRRRRRRRRNSGGSLEQLPW 2057
            .|:|:     .|..:....:|.|....       |:||     |.|.|........||..     
  Rat   281 WLKHV-----EVNGSKVGPDGTPYVTVLKSWISENVEA-----DARLRLANVSERDGGEY----- 330

  Fly  2058 AEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEK 2122
                         .|..|....:.:.       .|.:|..      ||.:.|.|     .:..::
  Rat   331 -------------LCRATNFIGVAEK-------AFWLRVH------GPQAAEEE-----LMEVDE 364

  Fly  2123 RGSLVLAI----------IAPAAIVSSC--------VLALVLVRKVQKRRLRAKKLLQQSRPSIW 2169
            .||:...:          |...|.|:.|        .|....|.||.:..|:.:::..:|..|:.
  Rat   365 AGSVYAGVLSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKVSRFPLKRQQVSLESNSSMN 429

  Fly  2170 SNLSTLQTQQQLMAVRNRAFSTTLSDADIALLP--QINWSQLKLLRFLGSGAFGEVYEGQ---LK 2229
            ||...::..:  ::.........:|:.::...|  :::.::|.|.:.||.|.||:|...:   :.
  Rat   430 SNTPLVRIAR--LSSGEGPVLANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGID 492

  Fly  2230 TEDSEEPQRVAIKSLRKGAS--EFAELLQEAQLMSNF-KHENIVCLVGICFDTESISLIMEHMEA 2291
            .:.:.:|..||:|.|:..|:  :.::|:.|.::|... ||:||:.|:|.|.....:.:::|:...
  Rat   493 KDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK 557

  Fly  2292 GDLLSYLRAAR---------ATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACR 2347
            |:|..:|||.|         |....|.|    |:..:|::....||.|..||.....:|||||.|
  Rat   558 GNLREFLRARRPPGMDYSFDACRLPEEQ----LTCKDLVSCAYQVARGMEYLASQKCIHRDLAAR 618

  Fly  2348 NCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWA 2412
            |.||||.       ..:||.|||||||::..|||:|...|.|||:||:||:|.|.::|.|||||:
  Rat   619 NVLVTED-------NVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 676

  Fly  2413 FGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRC 2477
            ||||.|||.|||..||......|:...:|||.|:.:|..||..||.::..||...|.:||:|::.
  Rat   677 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAVPSQRPTFKQL 741

  Fly  2478 YNTLHAI----STD 2487
            ...|..|    |||
  Rat   742 VEDLDRILTVTSTD 755

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996 22/118 (19%)
FN3 1993..2111 CDD:238020 22/124 (18%)
PTKc_c-ros 2213..2483 CDD:270640 108/284 (38%)
Fgfr3XP_006251454.1 IG_like 52..123 CDD:214653 14/76 (18%)
Ig strand B 55..59 CDD:409358 1/3 (33%)
Ig strand C 69..73 CDD:409358 1/3 (33%)
Ig strand E 91..94 CDD:409358 1/2 (50%)
Ig strand F 104..108 CDD:409358 1/3 (33%)
IgI_2_FGFR 145..239 CDD:409443 19/98 (19%)
Ig strand A 145..148 CDD:409443 0/2 (0%)
Ig strand A' 156..161 CDD:409443 0/4 (0%)
Ig strand B 165..173 CDD:409443 1/7 (14%)
Ig strand C 179..184 CDD:409443 1/4 (25%)
Ig strand C' 187..189 CDD:409443 0/3 (0%)
Ig strand D 198..201 CDD:409443 2/4 (50%)
Ig strand E 205..210 CDD:409443 2/4 (50%)
Ig strand F 219..226 CDD:409443 0/6 (0%)
Ig strand G 229..239 CDD:409443 1/9 (11%)
IgI_3_FGFR 247..347 CDD:409363 26/184 (14%)
Ig strand A 247..250 CDD:409363 0/2 (0%)
Ig strand A' 254..258 CDD:409363 2/25 (8%)
Ig strand B 266..273 CDD:409363 3/34 (9%)
Ig strand C 277..284 CDD:409363 2/6 (33%)
Ig strand D 299..304 CDD:409363 0/4 (0%)
Ig strand E 315..320 CDD:409363 2/4 (50%)
Ig strand F 328..336 CDD:409363 2/25 (8%)
Ig strand G 339..347 CDD:409363 1/14 (7%)
PTKc_FGFR3 456..789 CDD:173652 115/311 (37%)
Blue background indicates that the domain is not in the aligned region.

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