DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and MAP3K21

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_115811.2 Gene:MAP3K21 / 84451 HGNCID:29798 Length:1036 Species:Homo sapiens


Alignment Length:369 Identity:107/369 - (28%)
Similarity:169/369 - (45%) Gaps:42/369 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly  2204 INWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRK-----GASEFAELLQEAQLMSN 2263
            :.:.:|:|...:|:|.||:||..      :.:.|.||:|:.|:     .|:....:.:||:|.:.
Human   119 VAFERLELKELIGAGGFGQVYRA------TWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAM 177

  Fly  2264 FKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTA-------GLSLSELL 2321
            .:|.||:.|.|:|.....:.|::|....|.|...|.||.|.    |.|.|       .:....|:
Human   178 LRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAA----PDPRAPGPRRARRIPPHVLV 238

  Fly  2322 AMCIDVANGCSYLEDMHFV---HRDLACRNCLVTESTGSTD-RRRTVKIGDFGLARDIYKSDYYR 2382
            ...:.:|.|..||.:..||   ||||...|.|:.|.....| ..:|:||.||||||:.:::....
Human   239 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMS 303

  Fly  2383 KEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGG-RL 2446
            ..|    ...||:||.:...||:..||:|::|||.||:|| |:.||...:...|...|.... .|
Human   304 TAG----TYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAVNKLTL 363

  Fly  2447 QQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAIS----TDLRRTQMASATADTVVSCSRP 2507
            ..|..|.|....|:..||:.||..||||......|.||.    |::.:....|...|..:...:.
Human   364 PIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQM 428

  Fly  2508 EFKVRFDGQPLEEHREH------NERPEDENLTLREVPLKDKQL 2545
            ..::|...:.|....|.      .::.::|.|..||..|.::::
Human   429 FDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREI 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996
FN3 1993..2111 CDD:238020
PTKc_c-ros 2213..2483 CDD:270640 92/286 (32%)
MAP3K21NP_115811.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
SH3_MLK4 42..97 CDD:212991
Protein Kinases, catalytic domain 129..401 CDD:473864 92/286 (32%)
Leucine-zipper 1 425..446 3/20 (15%)
Leucine-zipper 2 460..481 4/13 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 517..551
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..791
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 923..954
Blue background indicates that the domain is not in the aligned region.

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