Protein Alignment sev and Frk

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_077344.1
• Gene: Frk / 79209
• RGDID: 621423
• Length: 506
• Species: Rattus norvegicus
• Alignment Length: 285
• Identity: 104/285 - (36%)
• Similarity: 164/285 - (57%)
• Gaps: 33/285 - (11%)

  Fly  2203 QINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHE 2267
            :|:.:.::||:.||||.||||:||   ..::..|  ||:|:|:.|:.:..:.|:|||:|.:.:|.
  Rat   229 EIDRNSIQLLKRLGSGQFGEVWEG---LWNNTTP--VAVKTLKPGSMDPNDFLREAQIMKSLRHP 288

  Fly  2268 NIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAG--LSLSELLAMCIDVANG 2330
            .::.|..:|...:.|.:|.|.|..|.|..||           |...|  :.|::.:.|...||:|
  Rat   289 KLIQLYAVCTLEDPIYIITELMRHGSLQEYL-----------QNDGGSKIRLTQQVDMAAQVASG 342

  Fly  2331 CSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYK---SDYYRKEGEGLLPVR 2392
            .:|||..:::|||||.||.||.|       ....|:.|||||| ::|   .|.|..:.|..|||:
  Rat   343 MAYLESQNYIHRDLAARNVLVGE-------HNIYKVADFGLAR-VFKVDNEDIYESKHEIKLPVK 399

  Fly  2393 WMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLY 2457
            |.:||::....|:.:||||:||:|.:||:|.|:.||:.....:|:..:.:..||.||..|.|:.|
  Rat   400 WTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIHMLGQNYRLPQPSNCPEQFY 464

  Fly  2458 SLLLLCWRTDPWERPSFRRCYNTLH 2482
            |:::.||..:|.:||:|    .|||
  Rat   465 SIMMECWNVEPKQRPTF----ETLH 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996
		FN3	1993..2111	CDD:238020
		PTKc_c-ros	2213..2483	CDD:270640	101/275 (37%)
Frk	NP_077344.1	SH3_Src_like	48..105	CDD:212779
		SH2_Src_Frk	113..208	CDD:199831
		PTKc_Frk_like	226..495	CDD:270653	104/285 (36%)