DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and Fgfr1

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_077060.2 Gene:Fgfr1 / 79114 RGDID:620713 Length:822 Species:Rattus norvegicus


Alignment Length:801 Identity:216/801 - (26%)
Similarity:338/801 - (42%) Gaps:162/801 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  1827 SESVYYTLHWQQEL-DGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNS 1890
            |::.|::::....| ..|:..|..:..:.|:..:....:|    :|.:.|  |    .:|.|  .
  Rat   109 SDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNR----RPVAPY--W----TSPEK--M 161

  Fly  1891 SERLHVRSFAELPELQLLELGPYSLSLTWAGT-----PDP---------------LGSLQLECRS 1935
            .::||....|:..:.:....|..|.:|.|...     ||.               :.|:....:.
  Rat   162 EKKLHAVPAAKTVKFKCPSSGTPSPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKG 226

  Fly  1936 SAEQLRRNVAG--NHTKM--VVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQP 1996
            :...:..|..|  |||..  |||    |:.::..|..|..|.....|......:.:...|  .||
  Rat   227 NYTCIVENEYGSINHTYQLDVVE----RSPHRPILQAGLPANKTVALGSNVEFMCKVYSD--PQP 285

  Fly  1997 GKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEP 2061
            ....|:||  ||          ||:.|...||..:|.           .:.:|.:...    :|.
  Rat   286 HIQWLKHI--EV----------NGSKIGPDNLPYVQI-----------LKTAGVNTTD----KEM 323

  Fly  2062 VVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEH--GWGPYSEESERVAEPFVSPEKRG 2124
            .|:..:.:.|.:..|.:|:..:            :..|.|  .|....|..|.......||    
  Rat   324 EVLHLRNVSFEDAGEYTCLAGN------------SIGLSHHSAWLTVLEALEERPAVMTSP---- 372

  Fly  2125 SLVLAII--APAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNR 2187
             |.|.||  ...|.:.||::..|::.|::.   ..||....|:.::.....::..::|:....:.
  Rat   373 -LYLEIIIYCTGAFLISCMVGSVIIYKMKS---GTKKSDFHSQMAVHKLAKSIPLRRQVTVSADS 433

  Fly  2188 AFS----------TTLSDADIALLPQIN---------W----SQLKLLRFLGSGAFGEVYEGQLK 2229
            :.|          :.||.:...:|..::         |    .:|.|.:.||.|.||:|...:..
  Rat   434 SASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAI 498

  Fly  2230 TEDSEEPQR---VAIKSLRKGASE--FAELLQEAQLMSNF-KHENIVCLVGICFDTESISLIMEH 2288
            ..|.::|.|   ||:|.|:..|:|  .::|:.|.::|... ||:||:.|:|.|.....:.:|:|:
  Rat   499 GLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 563

  Fly  2289 MEAGDLLSYLRAARATSTQ-----EPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRN 2348
            ...|:|..||:|.|....:     ...|...||..:|::....||.|..||.....:|||||.||
  Rat   564 ASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARN 628

  Fly  2349 CLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAF 2413
            .||||.       ..:||.||||||||:..|||:|...|.|||:||:||:|.|.::|.|||||:|
  Rat   629 VLVTED-------NVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSF 686

  Fly  2414 GVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCY 2478
            |||.|||.|||..||......|:...:|||.|:.:|..||.:||.::..||...|.:||:|::..
  Rat   687 GVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLV 751

  Fly  2479 NTLHAI----------STDLRRTQMASATADTVVS-CSRPEFKVRFDGQPLEEHREHNERPEDEN 2532
            ..|..|          ...:...|.:.:..||..| ||..|..| |..:||         ||:..
  Rat   752 EDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSV-FSHEPL---------PEEPC 806

  Fly  2533 LTLREVPLKDKQLYANEGVSR 2553
            |     |....|| ||.|:.|
  Rat   807 L-----PRHPTQL-ANGGLKR 821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996 12/64 (19%)
FN3 1993..2111 CDD:238020 23/119 (19%)
PTKc_c-ros 2213..2483 CDD:270640 112/280 (40%)
Fgfr1NP_077060.2 IgI_1_FGFR 25..118 CDD:409362 2/8 (25%)
Ig strand A 25..28 CDD:409362
Ig strand A' 40..46 CDD:409362
Ig strand B 49..59 CDD:409362
Ig strand C 63..68 CDD:409362
Ig strand C' 71..73 CDD:409362
Ig strand D 78..82 CDD:409362
Ig strand E 85..90 CDD:409362
Ig strand F 96..105 CDD:409362
Ig strand G 108..118 CDD:409362 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..162 10/53 (19%)
IgI_2_FGFR 153..247 CDD:409443 19/101 (19%)
Ig strand A 153..156 CDD:409443 2/8 (25%)
Heparin-binding 160..177 4/18 (22%)
Ig strand A' 164..169 CDD:409443 2/4 (50%)
Ig strand B 173..181 CDD:409443 0/7 (0%)
Ig strand C 187..192 CDD:409443 2/4 (50%)
Ig strand C' 195..197 CDD:409443 0/1 (0%)
Ig strand D 206..209 CDD:409443 0/2 (0%)
Ig strand E 213..218 CDD:409443 0/4 (0%)
Ig strand F 227..234 CDD:409443 0/6 (0%)
Ig strand G 237..247 CDD:409443 4/9 (44%)
Ig 255..359 CDD:472250 27/144 (19%)
Ig strand B 273..277 CDD:409444 0/3 (0%)
Ig strand C 286..290 CDD:409444 0/3 (0%)
Ig strand E 324..328 CDD:409444 1/3 (33%)
Ig strand F 338..343 CDD:409444 2/4 (50%)
Ig strand G 351..354 CDD:409444 1/2 (50%)
PTKc_FGFR1 464..765 CDD:270678 116/307 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 770..822 21/68 (31%)
Blue background indicates that the domain is not in the aligned region.

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