DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sev and ROS1

DIOPT Version :9

Sequence 1:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster
Sequence 2:	XP_011534351.1	Gene:	ROS1 / 6098	HGNCID:	10261	Length:	2357	Species:	Homo sapiens

Alignment Length:	2535	Identity:	648/2535 - (25%)
Similarity:	1011/2535 - (39%)	Gaps:	607/2535 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 VTRDCVQRCIVEEDLFLDEFGIQCEKADNGEKCYKTRCTKGCAQW---------------YRALK 265
            |...|::.|:......|| .|.....::        .|.:||..|               |..:.
Human    29 VLNSCLKSCVTNLGQQLD-LGTPHNLSE--------PCIQGCHFWNSVDQKNCALKCNDTYATVC 84

  Fly   266 ELESCQEACLSLQFYPYDMPCIGACEMAQRDYWHLQRLAISHLVERTQPQLERAPRADG-QSTPL 329
            |.|||:..|.|.:         ||.|              ..::|..  .|..||.|.. .|..:
Human    85 ERESCEVGCSSAE---------GAYE--------------EEVLENA--DLPTAPFASSIGSHNM 124

  Fly   330 TIRW-AMHFPEHYLASRPFNIQYQFVDHHGEELDLEQEDQDASGETGSSAWFNLADYDCDEYYVC 393
            |:|| :.:|     :...:.||:::....|                   :|..........|
Human   125 TLRWKSANF-----SGVKYIIQWKYAQLLG-------------------SWTYTKTVSRPSY--- 162

  Fly   394 EILEALIPYTQYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISAPVIEHLMGLDDSHLAVHW 458
             :::.|.|:|:|.||....|.....  ||||.:|:|:|.|.|.|.:||:|.::.......:.|.|
Human   163 -VVKPLHPFTEYIFRVVWIFTAQLQ--LYSPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSW 224

  Fly   459 HPGRFTNGPIEGYRLRLSSSEGNATSEQLVPAG--RGSYIFSQLQAGTNYTLALSMINKQGEGPV 521
            .|.:|..|||.||.|||.|      ..|.:.||  |.|:.|......|.|..:::.:|:.||||.
Human   225 DPPQFPGGPILGYNLRLIS------KNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPE 283

  Fly   522 AKGFVQTHSARNEKPAKDLTESVLLVGRRAVMWQSLEPAGENSMIYQSQEELADIAWSKREQQLW 586
            |:..:.|.|:     |....|..|.:.|:            .|:..:|.:.|.|.|...|...::
Human   284 AESSITTSSS-----AVQQEEQWLFLSRK------------TSLRKRSLKHLVDEAHCLRLDAIY 331

  Fly   587 ------LLNVHGELRSLKFESGQMVSPAQQLKL----DLGNISSGRWVPRRLSFDWLHHRLYFAM 641
                  .::||.::  :.|..|.::...:...:    ||.....|..:...:|.|||:.|:||.|
Human   332 HNITGISVDVHQQI--VYFSEGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYFIM 394

  Fly   642 ESPERNQSSFQIISTDLLGESTQKVGE----SFDLPVEQLEVDALNGWIFWRNEESLWRQDL--- 699
            :.        .:...||  |:...:.|    |...| :::..|:.||::|:...:.::|.||
Human   395 DE--------LVCVCDL--ENCSNIEEITPPSISAP-QKIVADSYNGYVFYLLRDGIYRADLPVP 448

  Fly   700 HGRMIH--RLLRIRQPGWFLVQPQHFIIHLMLPQEGKFLEISYDGGFKH-PLPLPPPSNGAGNGP 761
            .||...  |::.......|.::||...|.........|:....||...| .||..|
Human   449 SGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIP--------- 504

  Fly   762 ASSHWQSFALLGRSLLLPDSGQLILVEQQ--------GQAASPSASWPLKNLPDCWAVILLVPES 818
             .:..:|||......|:.| |::|..:..        |...|....:...||       ::...|
Human   505 -FADVKSFACENNDFLVTD-GKVIFQQDALSFNEFIVGCDLSHIEEFGFGNL-------VIFGSS 560

  Fly   819 QPLTSAGGKPHSLKALLGAQAAKISWKEP------------------ERNPYQSADAARSWSYEL 865
            ..|....|:|..|..|.|:..|.:.||.|                  |..|    .|.::|:||:
Human   561 SQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGP----SAWQNWTYEV 621

  Fly   866 EVLDVASQSAFSIR----NIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTEPLAARTWPLGP 926
            :   |::|....:.    ||.|.:..:..||....|::.||| :....||.|:||....|
Human   622 K---VSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRA-SSPKRPGPWSEPSVGTT----- 677

  Fly   927 HRLRWASRQGSVIHTNELGEGLEVQQEQLERLP----GPMTMVNESVG------------YY--V 973
                       ::..:|....:.|:::.|...|    ||...::..:|            ||  .
Human   678 -----------LVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDT 731

  Fly   974 TGDGLLHCINLVHSQWGCPISE-----PLQHVGSVTYDWRGGRVYWTDLARNCVV-RMDPWSGSR 1032
            .||..:..:|      |..|||     .:...|::.::|.|..:||.  .:..|: |....:|..
Human   732 KGDVFVWLLN------GTDISENYHLPSIAGAGALAFEWLGHFLYWA--GKTYVIQRQSVLTGHT 788

  Fly  1033 ELLPVFE--ANFLALDPRQGHLYYAT-----SSQLSRHGSTPDEAVTYYRVNGLEGSIASFVLDT 1090
            :::...:  .|.:.:|...|:||:.|     |::|:...|...:...::  :|.:  :.:..||.
Human   789 DIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWF--SGKK--VIALTLDL 849

  Fly  1091 QQDQLFWLVKGSGALRLYRAPL---TAGGDSLQMIQQIKGVFQAVPDSLQLLRPLGALLWLERSG 1152
            ....|:|||:.|..:.||.|.|   ::.||:  .|.:......:......|:...|.|.|:  :|
Human   850 SDGLLYWLVQDSQCIHLYTAVLRGQSSTGDT--TITEFAAWSTSEISQNALMYYSGRLFWI--NG 910

  Fly  1153 RRARLVRLAAPLDVMELPTPDQASPASALQLLDP-------------QPLP------PRDEGVIP 1198
            .|              :.|..:....:::.:|:|             :|||      |:   |||
Human   911 FR--------------IITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPK---VIP 958

  Fly  1199 MTVLPDSVRLDDGHWDDFHVRWQ--PSTSGG--NHSVSYRLLLEFGQRLQTLDLSTPFARLTQL- 1258
            .:|...|.|: :|:...|.:.|.  |:...|  .:||.:....:|   |.:...|.|...:..|
Human   959 DSVQESSFRI-EGNASSFQILWNGPPAVDWGVVFYSVEFSAHSKF---LASEQHSLPVFTVEGLE 1019

  Fly  1259 PQAQLQLKISITPRTAWRSGDTTRVQLTTPPVAPSQPRRLRVFVERLATALQEANVSAVLRWDAP 1323
            |.|...|  |:||.|.|..|..|.:.|..|...||.|...|:|:........:..|....||:.|
Human  1020 PYALFNL--SVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKP 1082

  Fly  1324 --EQGQEAPMQALEYHIS--------C--WVGSELHEELRLNQSALEARVEHLQPDQTYHFQVEA 1376
              |.|.....: :.|:||        |  |:.      :.:..|.:..::|.:.|.....|||.
Human  1083 KHENGVLTKFE-IFYNISNQSITNKTCEDWIA------VNVTPSVMSFQLEGMSPRCFIAFQVR- 1139

  Fly  1377 RVAATGAAAGA-ASHALHVAPEVQAVPRVLYANAEFIGELDLDTRNRRRLVHTASPVEHLVGIEG 1440
              |.|....|. |........|:...|.::......|..||:| :|:.....:|..|...|....
Human  1140 --AFTSKGPGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMD-QNQVVWTFSAERVISAVCYTA 1201

  Fly  1441 EQRLLWVNEHVEL-LTHVPGSAPAKLAR--MRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRL 1502
            :..:.:..|...| |.|:...:.::|.:  :..::..:.:|||.|.:|:|..:  :.....::.:
Human  1202 DNEMGYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKE--SQNGMQVFDV 1264

  Fly  1503 DLCNFEGKILQGERVWSTPRGRLLKDLVALPQAQSLIWLE-----YE------------------ 1544
            ||   |.|:.....|....|...:......|....|.|.|     |:
Human  1265 DL---EHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPT 1326

  Fly  1545 ---QGSPRNG--------SLRGRNLTDGSELEWATVQPLIRLHAGSLEPGSETLNLVDNQGKLCV 1598
               |.:.||.        .|.|....|.|.||    :|||..      ..::.:..:|.:|..|
Human  1327 ATNQQNKRNQCSCNVTEFELSGAMAIDTSNLE----KPLIYF------AKAQEIWAMDLEGCQC- 1380

  Fly  1599 YDVARQLCTASALRAQLNLLGEDSIAGQL------AQDSGYLYAVKNWS------IRAYGRRRQQ 1651
                .::.|..|:.|...|:.. ::.|.|      |:||..:|..|..:      ::|. |.|..
Human  1381 ----WRVITVPAMLAGKTLVSL-TVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKAL-RSRHI 1439

  Fly  1652 LEYTVELEPEEVRLLQAHNYQAYPPKNCLLLPSS--GGSLLKATDCEEQRCLLHLPM-------- 1706
            |.|:..::|             :|.|..|.|.|.  ..::|.||:..   ..:.||:
Human  1440 LAYSSVMQP-------------FPDKAFLSLASDTVEPTILNATNTS---LTIRLPLAKTNLTWY 1488

  Fly  1707 -ITASEDCPLPIPGVRYQLNLTLAKEPGSEEHDH-GMEPLGQWLLGAGESLNL-TDLLPFTRYRV 1768
             ||:    |.|...|.|           :|.:|. ....|...:|...:|:.| .||.||:.|.:
Human  1489 GITS----PTPTYLVYY-----------AEVNDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMI 1538

  Fly  1769 SGILSSFYQKKLALPTLVLAPLELL---------TASATPSPPRNFSVRVLSPRELEVSWLPPEQ 1824
            ...:.::|..          |||.|         |.:..|...:..:..|.|...|.:||....:
Human  1539 QIAVKNYYSD----------PLEHLPPGKEIWGKTKNGVPEAVQLINTTVRSDTSLIISWRESHK 1593

  Fly  1825 LR--SESVYYTL---HW---------QQE------------LDGENVQDRREWEAHERRLETAGT 1863
            ..  .|||.|.|   |.         |.|            |.|.|:...:....|...:....:
Human  1594 PNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLACHSEEMWCTES 1658

  Fly  1864 HRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPE---LQLLELGPYSLSLT--WAGTP 1923
            |.:|           |:...||.|          .::.:||   ||.....|.:::|.  |.
Human  1659 HPVT-----------VEMFNTPEK----------PYSLVPENTSLQFNWKAPLNVNLIRFWV--- 1699

  Fly  1924 DPLGSLQ-------LECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHG 1981
                .||       ...::|..|....|..      :..|||.|.|..|:::.|.....:.   .
Human  1700 ----ELQKWKYNEFYHVKTSCSQGPAYVCN------ITNLQPYTSYNVRVVVVYKTGENST---S 1751

  Fly  1982 TAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRR 2046
            ..|.::|....|::||.|:|...::.  .:.|..|..||..|..|.||       ||:......:
Human  1752 LPESFKTKAGVPNKPGIPKLLEGSKN--SIQWEKAEDNGCRITYYILE-------IRKSTSNNLQ 1807

  Fly  2047 NSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESE 2111
            |     :.|.|.          :.|..:....|..||.:...:..|||.|.: ..|:|.||..||
Human  1808 N-----QNLRWK----------MTFNGSCSSVCTWKSKNLKGIFQFRVVAAN-NLGFGEYSGISE 1856

  Fly  2112 R---VAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLS 2173
            .   |.:.|..||.  |.:|.||....:|.:..|..     |..|||:.:|..::....:
Human  1857 NIILVGDDFWIPET--SFILTIIVGIFLVVTIPLTF-----VWHRRLKNQKSAKEGVTVL----- 1909

  Fly  2174 TLQTQQQLMAVRNRAFSTTLSDA-----------DIALLPQINWSQLKLLRFLGSGAFGEVYEGQ 2227
             :...::|..:|..|....|::|           :|..||.....:|.|...||||||||||||.
Human  1910 -INEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGT 1973

  Fly  2228 ----LKTEDSEEPQRVAIKSLRKGAS--EFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIM 2286
                |.....|  .:||:|:|:||::  |..|.|:||.|||.|.|.||:..:|:|...|...:|:
Human  1974 AVDILGVGSGE--IKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIIL 2036

  Fly  2287 EHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLV 2351
            |.||.||||:|||.||..:...|.    |:|.:|:.:|:|::.||.|||.|||:|||||.|||||
Human  2037 ELMEGGDLLTYLRKARMATFYGPL----LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLV 2097

  Fly  2352 TESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVL 2416
              |.......|.||||||||||||||:|||||.||||||||||:||||:||:||||||||:||:|
Human  2098 --SVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGIL 2160

  Fly  2417 CWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTL 2481
            .|||||||.|||.|.:|.:||.:|:.||||:.|..|.:.|::|:..||..:|.:||:|.|..:.|
Human  2161 IWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL 2225

Fly 2482 2481
Human 2226 2225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470	27/82 (33%)
		FN3	826..921	CDD:238020	31/116 (27%)
		LY	993..1026	CDD:214531	10/38 (26%)
		FN3	1292..1374	CDD:214495	20/93 (22%)
		FN3	1799..1897	CDD:238020	24/123 (20%)
		FN3	1993..2111	CDD:238020	30/117 (26%)
		Pkinase_Tyr	2209..2481	CDD:285015	152/277 (55%)
		PTKc_c-ros	2213..2483	CDD:270640	151/275 (55%)
ROS1	XP_011534351.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157050
Domainoid	1	1.000	291	1.000	Domainoid score	I1541
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2207
Inparanoid	1	1.050	507	1.000	Inparanoid score	I1342
Isobase	1	0.950	-	0	Normalized mean entropy	S6145
OMA	1	1.010	-	-		QHG47409
OrthoDB	1	1.010	-	-		D203310at2759
OrthoFinder	1	1.000	-	-		FOG0006628
OrthoInspector	1	1.000	-	-		oto90241
orthoMCL	1	0.900	-	-		OOG6_108587
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5629
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.620