Protein Alignment sev and Insrr

DIOPT Version :9

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_071548.2
• Gene: Insrr / 60663
• RGDID: 67399
• Length: 1300
• Species: Rattus norvegicus
• Alignment Length: 1107
• Identity: 283/1107 - (25%)
• Similarity: 427/1107 - (38%)
• Gaps: 332/1107 - (29%)

  Fly  1527 KDLVALPQAQSLIWLEYEQGSPRNGSLRGRNLTDGSELEWATVQPL------------------- 1572
            |.:.::...|.|:...:.:||......:|.||....:.....|:.:
  Rat   333 KTIDSVQATQDLVGCTHVEGSLILNLRQGYNLEPELQRNLGLVETITGFLKIKHSFALVTLGFFK 397

  Fly  1573 -IRLHAG-SLEPGSETLNLVDNQG-------------------------KLC---VYDVA----- 1602
             ::|..| |:..|:.||.::|||.                         :||   :|.:.
  Rat   398 NLKLIRGDSMVDGNYTLYVLDNQNLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYQLEEVTGT 462

  Fly  1603 ----------------RQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQ 1651
                            |..|....||...||..||.|             :..|.
  Rat   463 RGRQSKAEINPRTNGDRAACQTRTLRFVFNLTEEDRI-------------LLRWE---------- 504

  Fly  1652 LEYTVELEPEEVRLLQAH--NYQAYPPKNCLLLPSSGGSLLKATDCEEQRCLLHL-PMITASEDC 1713
                 ..||.|.|.|.:.  .|:..|.:|             ||:        |: |....::..
  Rat   505 -----RYEPLEARDLLSFIVYYKESPFQN-------------ATE--------HVGPDACGTQSW 543

  Fly  1714 PLPIPGVRYQLNLTLAKEPGSEEHDHGMEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQK 1778
            .|    :..:|.|:..:|||                     :.|..|.|:|:|.|       :.:
  Rat   544 NL----LDVELPLSRTQEPG---------------------VTLAPLKPWTQYAV-------FVR 576

  Fly  1779 KLALPTLVLAP--------LELLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLH 1835
            .:.|.|...:|        :.|.|..|.|:.|::......|...|.|.|.||.|......||.:.
  Rat   577 AITLTTAEDSPHQGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVRWKPPVQRNGNITYYLVL 641

  Fly  1836 WQQ-ELDGE-NVQD------RREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSE 1892
            ||: ..||: .:.|      |....:|:.|.:....  ....:|..|  .....|:.|.::
  Rat   642 WQRLAEDGDLYINDYCHRGLRLPTSSHDTRFDREDP--ALEAEPEQG--CCPCQHSPPGQA---- 698

  Fly  1893 RLHVRSFAELPELQLLEL-------GPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVA----- 1945
                     ||.|:..|:       .....::|....|..:.|:....:..:|:.||...
  Rat   699 ---------LPALEAQEVTFQKKFENFLHHAITIPKAPWKVTSINKNPQRDSERHRRETGLLRLG 754

  Fly  1946 -GNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLY-------HGTAEVYETLG------------ 1990
             .|....:.|...||.|         |...|...:       |.......|:|
  Rat   755 KNNSDFEIHEDKVPRER---------AVLSGLRHFTEYRIDIHACNHAAHTVGCSAATFVFARTM 810

  Fly  1991 ---DAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLE-----ALQARSDIRRRRRRRRRN 2047
               :|...|||            |.|.|.  ..:.:.|:.||     .|..:.:|:.||
  Rat   811 PHREADGIPGK------------VVWKAV--GKSSVILHWLEPPDPNGLILKYEIKYRR------ 855

  Fly  2048 SGGSLEQLPWAEEPVVVEDQWLDFCNT--TELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEES 2110
                     ..||..|:....|.:...  ..|:.:....:|:     :|||.||. |.|.:   :
  Rat   856 ---------LGEEATVLCVSRLRYAKVGGVHLALLPPGNYSA-----KVRATSLA-GNGSW---T 902

  Fly  2111 ERVAEPFVSPEKR---GSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNL 2172
            :.||.....||:.   |..:|..:.|...:...:||.:.....:||.
  Rat   903 DGVAFYITGPEEEDTGGLRILLTVTPVGFMLLVMLAALGFFYSKKRN------------------ 949

  Fly  2173 STLQTQQQLMAVRNRAFSTTLSDADIALLPQINW----SQLKLLRFLGSGAFGEVYEGQLK-TED 2232
            |||.|     :|....||     |....:|. .|    .|:.::|.||.|:||.||||..: .|.
  Rat   950 STLYT-----SVNPEYFS-----ASHMYVPD-EWEVPREQIAIIRELGQGSFGMVYEGLARGLEA 1003

  Fly  2233 SEEPQRVAIKSLRKGAS--EFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLL 2295
            .||...||:|::.:.||  |..|.|:||.:|..||..::|.|:|:....:...:|||.|..|||.
  Rat  1004 GEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLK 1068

  Fly  2296 SYLRAARATSTQE---PQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGS 2357
            |:||:.|..:...   |||    :||:::.|..::|:|.:||....|||||||.|||:|::..
  Rat  1069 SHLRSLRPEAENNPGLPQP----ALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDF-- 1127

  Fly  2358 TDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILT 2422
                 ||||||||:.||:|::|||||.|:||||||||:||||.||:|||.||||:|||:.|||:|
  Rat  1128 -----TVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVT 1187

  Fly  2423 LGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTD 2487
            |.:|||...:|.:||..|.:||.|::...|..:|..|:..||:..|..||:|   .:.|..|..:
  Rat  1188 LAEQPYQGLSNEQVLKFVMDGGVLEEQEDCPIQLQELMRRCWQHTPRLRPTF---VHILDRIQDE 1249

  Fly  2488 LR 2489
            ||
  Rat  1250 LR 1251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020	23/105 (22%)
		FN3	1993..2111	CDD:238020	26/124 (21%)
		Pkinase_Tyr	2209..2481	CDD:285015	126/277 (45%)
		PTKc_c-ros	2213..2483	CDD:270640	127/275 (46%)
Insrr	NP_071548.2	Recep_L_domain	47..158	CDD:279382
		Furin-like	173..326	CDD:279142
		FU	228..275	CDD:238021
		Recep_L_domain	346..460	CDD:279382	18/113 (16%)
		FN3	494..600	CDD:238020	32/186 (17%)
		FN3	605..>649	CDD:238020	13/43 (30%)
		FN3	819..908	CDD:238020	28/126 (22%)
		PTKc_InsR_like	972..1248	CDD:173625	130/289 (45%)
		Pkinase_Tyr	979..1246	CDD:285015	127/280 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1270..1300

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010