DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and fgfr3

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:XP_009305459.1 Gene:fgfr3 / 58129 ZFINID:ZDB-GENE-000816-1 Length:820 Species:Danio rerio


Alignment Length:875 Identity:221/875 - (25%)
Similarity:351/875 - (40%) Gaps:215/875 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1787 LAPLELLTASATPSPPRNFSVRVLSPRELEVSWLPPE------------------QLRSESVYYT 1833
            :.||.||...||...|..:|..:|||...:  |:..|                  ....:.....
Zfish    20 MVPLCLLLYLATLVFPPVYSAHLLSPEPTD--WVSSEVEVFLEDYVAGVGDTVVLSCTPQDFLLP 82

  Fly  1834 LHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIK-PGSGYSLWVQAHATPTKSNSSERLHVR 1897
            :.||:  ||:.|.........::.|      |:..:. ..||......||.:...||.:.::   
Zfish    83 IVWQK--DGDAVSSSNRTRVGQKAL------RIINVSYEDSGVYSCRHAHKSMLLSNYTVKV--- 136

  Fly  1898 SFAELPELQLLELG---PYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPR 1959
                   :..|..|   .|......||.    |:.:....:.::::.:       |::..|....
Zfish   137 -------IDSLSSGDDEDYDEDEDEAGN----GNAEAPYWTRSDRMEK-------KLLAVPAANT 183

  Fly  1960 TRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAA----RGN- 2019
            .:::|.     ||....|..|......|..|:  .:.|..:|.   ::.:.:...:|    ||| 
Zfish   184 VKFRCP-----AAGNPTPSIHWLKNGKEFKGE--QRMGGIKLR---DQQWSLVMESAVPSDRGNY 238

  Fly  2020 --------GAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVED---------- 2066
                    |.....|.|:.|:      |...|....:|     ||..:..||..|          
Zfish   239 TCVVQNKYGTIKHTYQLDVLE------RSPHRPILQAG-----LPANQTVVVGSDVEFHCKVYSD 292

  Fly  2067 -----QWLDFC---------NTTELSCIVKSLHSS------RLLLFRVRARSL------EHGWGP 2105
                 |||...         |......::||..|:      .|.::.|..:..      .|.:..
Zfish   293 AQPHIQWLKHIEVNGSQYGPNGAPYVNVLKSFVSNVKEAQDTLTVYNVSEKDAGQYWCRAHNFLG 357

  Fly  2106 YSEES--ERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVL---------------------V 2147
            .||.|  ..|::|.|..|:.......:|    .|:||||.::.                     |
Zfish   358 MSENSFWLTVSQPAVEMEREDDYADILI----YVTSCVLFILTMVIIILCRMWINTQKTLPAPPV 418

  Fly  2148 RKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALLPQIN------- 2205
            :|:.|..|:.:::..:|..|:.||...::..:             ||.:|..:||.::       
Zfish   419 QKLSKFPLKRQQVSLESNSSMNSNTPLVRIAR-------------LSSSDGPMLPNVSELELPSD 470

  Fly  2206 --W----SQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQR---VAIKSLRKGAS--EFAELLQEAQ 2259
              |    ::|.|.:.||.|.||:|...:....|.|:|.:   ||:|.|:...:  :.::|:.|.:
Zfish   471 PKWEFTRTKLTLGKPLGEGCFGQVVMAEAIGIDKEKPNKPLTVAVKMLKDDGTDKDLSDLVSEME 535

  Fly  2260 LMSNF-KHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARA-------TSTQEPQPTAGLS 2316
            :|... ||:||:.|:|.|.....:.:::|:...|:|..||||.|.       .:.:.|..|  |:
Zfish   536 MMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPNET--LT 598

  Fly  2317 LSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYY 2381
            ..:|::....||.|..||.....:|||||.||.||||.       ..:||.|||||||::..|||
Zfish   599 FKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED-------NVMKIADFGLARDVHNIDYY 656

  Fly  2382 RKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRL 2446
            :|...|.|||:||:||:|.|.::|.|||||::|||.|||.|||..||......|:...:|||.|:
Zfish   657 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRM 721

  Fly  2447 QQPPMCTEKLYSLLLLCWRTDPWERPSFRRCY----NTLHAISTD------LRRTQMASATADTV 2501
            .:|..||.:||.::..||...|.:||:||:..    ..|...|||      :...|.:....|:.
Zfish   722 DKPANCTHELYMIMRECWHAVPSQRPTFRQLVEDHDRVLSMTSTDEYLDLSVPFEQYSPTCPDSN 786

  Fly  2502 VSCSRPEFKVRFDGQPLEE------HREHN 2525
            .:||..:..| |...||.|      |...|
Zfish   787 STCSSGDDSV-FAHDPLPEEPCLPKHHHSN 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996 20/109 (18%)
FN3 1993..2111 CDD:238020 31/168 (18%)
PTKc_c-ros 2213..2483 CDD:270640 109/286 (38%)
fgfr3XP_009305459.1 Ig 46..120 CDD:472250 11/83 (13%)
Ig strand B 70..74 CDD:409353 0/3 (0%)
Ig strand C 82..86 CDD:409353 0/3 (0%)
Ig strand E 103..107 CDD:409353 1/9 (11%)
IgI_2_FGFR 163..257 CDD:409443 18/110 (16%)
Ig strand A 163..166 CDD:409443 0/2 (0%)
Ig strand A' 174..179 CDD:409443 1/4 (25%)
Ig strand B 183..191 CDD:409443 1/12 (8%)
Ig strand C 197..202 CDD:409443 1/4 (25%)
Ig strand C' 205..207 CDD:409443 0/1 (0%)
Ig strand D 216..219 CDD:409443 0/2 (0%)
Ig strand E 223..228 CDD:409443 0/4 (0%)
Ig strand F 237..244 CDD:409443 1/6 (17%)
Ig strand G 247..257 CDD:409443 3/9 (33%)
IgI_3_FGFR 265..366 CDD:409363 19/105 (18%)
Ig strand A 265..268 CDD:409363 0/2 (0%)
Ig strand A' 272..276 CDD:409363 1/3 (33%)
Ig strand B 284..291 CDD:409363 0/6 (0%)
Ig strand C 295..302 CDD:409363 3/6 (50%)
Ig strand D 317..322 CDD:409363 0/4 (0%)
Ig strand E 333..338 CDD:409363 1/4 (25%)
Ig strand F 346..354 CDD:409363 0/7 (0%)
Ig strand G 357..365 CDD:409363 3/7 (43%)
PTKc_FGFR3 467..800 CDD:173652 121/342 (35%)
Blue background indicates that the domain is not in the aligned region.

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