Protein Alignment sev and fes

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: XP_005166438.1
• Gene: fes / 566739
• ZFINID: ZDB-GENE-100812-10
• Length: 835
• Species: Danio rerio
• Alignment Length: 1072
• Identity: 244/1072 - (22%)
• Similarity: 401/1072 - (37%)
• Gaps: 321/1072 - (29%)

  Fly  1490 DATAPQ--AAIIYRLDLCNFEGKILQGERVWSTPRGRLLKDL-VALPQAQSLIWLEYEQGSPRNG 1551
            |...||  ||:   :.|.:.|.::::..:.|...|.:..::. :.|.|..:::  |..:|:...|
Zfish     6 DLWCPQGHAAL---MKLQDSELRLMEVMKKWMMQRAKSDREFSMQLHQMSAMV--EKMEGTQPGG 65

  Fly  1552 SLRGRNLTDGSELEW-------ATVQPLIRLHAGSLEPG---SETLNLVDNQGKLCVYD-----V 1601
               |.|........|       .::..::|.|:..|..|   ..||.:.|.|.....|.     :
Zfish    66 ---GLNYISQFNKSWNVLVSQTESLSRIMRKHSDDLMVGPLSKLTLLIRDKQQLRKTYGEQWTLL 127

  Fly  1602 ARQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQ-----LEYTVELEPE 1661
            .:.:|..:  :.:|:.|  .|...||.:|:  .||.|.:...:..|.|.:     ::.|::|...
Zfish   128 NQDMCRVT--QTELDRL--KSSYRQLVRDA--TYAKKKYQEASKDRERDKAKERFIKATLKLHEH 186

  Fly  1662 ------EVRLLQAHNYQAYPPKNCLLLPSSGGSL----------LK---------ATDCEEQRCL 1701
                  .|:..|.|:...|......||    |:|          ||         ::..:::...
Zfish   187 HNEYVLSVKAAQVHHQLHYGQSQPALL----GALQTLQEEMVLILKEILQEYFDLSSLIQDEVVS 247

  Fly  1702 LHLPMITASEDCPLPIPGVRY----QLNLTLAKEPGSEEHD-------HGMEPLGQWLLGAGESL 1755
            :|..|..|.:...   |...|    |.|.:..:.|...|.|       ..:||         |.|
Zfish   248 VHTEMANALKAIQ---PHKEYDNFIQQNRSRGEVPACVEFDCSLLEEADALEP---------EDL 300

  Fly  1756 NLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATPSPPRNFSVRVLSPRELEVSWL 1820
            .|.:|      .|.||     |.:     |.....|||..::|           ||.::..|:
Zfish   301 QLNEL------TVEGI-----QHR-----LTAVEEELLGLAST-----------LSSQQATVN-- 336

  Fly  1821 PPEQLRSESVYYTLHWQQELDGENVQD-RREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHAT 1884
                            |.|||   :|| .|.....:|..:.:..:.|...:.....|:.|:|...
Zfish   337 ----------------QLELD---LQDEERSANIGQRVYQFSKRNALEDSRQQVVLSMVVRARLE 382

  Fly  1885 PTKSNSSERLHVRSFAELPELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHT 1949
            ..:...:::|......|||.   |.|....:|||         |...|.....:.|..:|..||.
Zfish   383 AQRRLLADKLQCLGTNELPS---LGLDDDRISLT---------SSNSERDKDHKHLNIDVIRNHL 435

  Fly  1950 KMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWT 2014
            ..:.:|     :|                   |:.|:.|....|  |....:..:.:.:.:..|.
Zfish   436 SSLFKP-----KY-------------------TSSVFYTPQQVP--PALTPVPDVEKPLTQQVWY 474

  Fly  2015 AARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSC 2079
                :||...:...|.|              :|.|..|.:....::..|:...|...|.
Zfish   475 ----HGAIPRMEVQELL--------------KNDGDFLVRESQGKQEYVLSVHWGGQCR------ 515

  Fly  2080 IVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLAL 2144
                 |      |.:::..     |.|..:    .|.|:|                     |..|
Zfish   516 -----H------FLIQSTD-----GVYRLD----GEGFIS---------------------VPLL 539

  Fly  2145 VLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFS---TTLSDADIAL---LPQ 2203
            |                                        |..|:   |.....:|.|   :|:
Zfish   540 V----------------------------------------NHLFNSHQTVTKRTEIVLKKPIPK 564

  Fly  2204 INW----SQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKG--ASEFAELLQEAQLMS 2262
            ..|    ..:.|.:.:|.|.||||:.|:|:::::.    ||:|:.|:.  |....:.|.||:::.
Zfish   565 DKWVLEHDDVILGQSIGRGNFGEVFSGRLRSDNTP----VAVKACRENLPAEHKNKFLMEARILK 625

  Fly  2263 NFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAG--LSLSELLAMCI 2325
            .:.|.|||.|:|:|...:.|.:|||.::.||.|::||            |.|  |..|.|:.|..
Zfish   626 QYDHPNIVKLIGVCTQKQPIYIIMELVQGGDFLTFLR------------TEGHNLKSSMLIRMAE 678

  Fly  2326 DVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLP 2390
            :||:|.:|||....:|||:|.|||||.|.:       .|||.|||::|:.....|....|...:|
Zfish   679 NVASGLAYLESKKCIHRDVAARNCLVGEES-------VVKISDFGMSREEQDGVYSATGGMKQIP 736

  Fly  2391 VRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPY---AARNNFEVLAHVKEGGRLQQPPMC 2452
            |:|.:||:|..|.:||:||||:||||.||..:.|..||   ...:|.:....|:.|.|:..|..|
Zfish   737 VKWTAPEALNYGRYTTESDVWSFGVLLWETFSRGVTPYTIPTVMSNQQTRDEVERGYRMPAPNNC 801

  Fly  2453 TEKLYSLLLLCWRTDPWERPSFRRCYNTLHAI 2484
            .:::|:|:..||:.||.:||||.:....|.|:
Zfish   802 PDEIYTLMCQCWQYDPRKRPSFLKLKADLGAL 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	15/91 (16%)
		FN3	1993..2111	CDD:238020	17/117 (15%)
		PTKc_c-ros	2213..2483	CDD:270640	102/276 (37%)
fes	XP_005166438.1	F-BAR_Fes	7..243	CDD:153369	49/253 (19%)
		SH2_Fps_family	466..550	CDD:198224	23/188 (12%)
		Protein Kinases, catalytic domain	577..831	CDD:473864	101/276 (37%)