DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sev and lmtk2

DIOPT Version :9

Sequence 1:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster
Sequence 2:	NP_001313401.1	Gene:	lmtk2 / 564666	ZFINID:	ZDB-GENE-100812-11	Length:	1446	Species:	Danio rerio

Alignment Length:	364	Identity:	110/364 - (30%)
Similarity:	171/364 - (46%)	Gaps:	47/364 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  2197 DIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEP--QRVAIKSLRKGAS--EFAELLQE 2257
            |::..|.:....|..::.:|:|.||:|    |.:|...:|  .|..::.|:..||  |..|.||:
Zfish   123 DVSSGPHVARHSLSYIQEIGNGWFGKV----LLSEIYVDPGVARAVVRELKANASSKEQNEFLQQ 183

  Fly  2258 AQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLA 2322
            .......:|.||:..:|.|.:.....|:.|:.|.|||.||:       :|.........|.:|..
Zfish   184 GDPYRVLQHPNILQCLGQCVEAIPFLLVFEYCELGDLKSYV-------SQHEWLYRNGELLQLQK 241

  Fly  2323 MCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEG 2387
            |..::|.|.:::...:|:|.|||.|||.:|     ||  .|||:||:|:....:|.||...|.:.
Zfish   242 MACEIAAGVTHMHKHNFLHSDLALRNCFLT-----TD--LTVKVGDYGIGPTNFKEDYITTEDDQ 299

  Fly  2388 LLPVRWMSPE---SLVDGLFTTQ----SDVWAFGVLCWEILTLGQQPYAARNNFEVLAHV--KEG 2443
            .:.:||:|||   .|..||.|::    |:|||.||..||:....:|||...::.|||.||  .:.
Zfish   300 CVALRWLSPELIGELHGGLITSEQTKPSNVWALGVTIWELFECAKQPYHHLSDREVLHHVLKDQQ 364

  Fly  2444 GRLQQPPM---CTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVV--S 2503
            .||.:|.:   .:|:.|.:|..||.  |.::   |.....:|.:.|.||.........|...  |
Zfish   365 VRLLKPQLDLPYSERWYEVLQFCWL--PADK---RATAEEVHRLLTYLRMQGQKDVEDDFEQRWS 424

  Fly  2504 CSRP-----EFKVRFDGQPLEEHREHNERPEDENLTLRE 2537
            ..:|     :..|.....|:.|..:....| ||.||:.|
Zfish   425 SLKPNPSTRQATVSHSSFPILEQFDDGREP-DEVLTVTE 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020
		FN3	1993..2111	CDD:238020
		Pkinase_Tyr	2209..2481	CDD:285015	92/287 (32%)
		PTKc_c-ros	2213..2483	CDD:270640	91/285 (32%)
lmtk2	NP_001313401.1	STYKc	135..404	CDD:214568	93/291 (32%)
lmtk2	NP_001313401.1	PKc_like	137..406	CDD:304357	92/291 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000