Protein Alignment sev and ltk

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_001006661.2
• Gene: ltk / 564470
• ZFINID: ZDB-GENE-030616-115
• Length: 1530
• Species: Danio rerio
• Alignment Length: 1012
• Identity: 266/1012 - (26%)
• Similarity: 406/1012 - (40%)
• Gaps: 285/1012 - (28%)

  Fly  1696 EEQRCLLH---LPMITASEDCPLPIPGVRY-QLNLTL---AKEPGSEEHDHGMEPLGQWLLGAGE 1753
            :|:..|:.   ||...:::||.|.....|| ..|.|:   ..|.|:.......|..|.|.....|
Zfish   331 DEREALVQSPALPSTISNQDCQLQFSLYRYGDFNGTVLLSVVESGASAPALIWERSGHWKDAWQE 395

  Fly  1754 -SLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPL-------EL--------LTASATPSPP 1802
             :|.:|::|.....:|....:|..:..:||..:.|:..       ||        |..|..|.|
Zfish   396 ITLPITEILNGFHLKVQAFWTSGSKADIALDDISLSAACFDTELNELLHEGLPHDLDFSPLPEP- 459

  Fly  1803 RNFSVRVLSPRELEVSW----------LPPEQLRSESVYYTLHWQQELDGEN-VQDRREWEAHER 1856
               |....||    ::|          ..|.|.:.:|.|...:....:..|. ::..:.|
Zfish   460 ---SASEASP----ITWWFTSCGASGPFGPTQAQCDSAYRNTNVSVVVGKEGPLRGVQMW----- 512

  Fly  1857 RLETAGTHRLT--GIKPGSG--------YSLWVQA-------------------HATPTKSNSSE 1892
            ::....|::::  |...|.|        :.:::.|                   .|.|.::..:.
Zfish   513 KVPATNTYKISAYGAAGGKGAKNHNKRSHGVFISATFPLEKGDILYILIGHQGEDACPGRNPQTH 577

  Fly  1893 RLHVRSFAELPELQLLELGPYS--LSLTWA-----------------GTPDPL-------GSLQL 1931
            ::.      |.|..::|.|..|  .:|.||                 |.|.||       |...|
Zfish   578 KIC------LGESSVIEDGFDSDGSALKWAGGGGGGGGATYIYRMENGQPLPLLIAAGGGGKAYL 636

  Fly  1932 E-CRSSAEQLRRNVAGNHT----------------------------KMVVEPLQPRTRY-QCRL 1966
            | ..||.:|..|....|.|                            |.:||..|..:.. :...
Zfish   637 EDPESSQDQSFREQYENDTTVSGVSGRSGAAGGGGGWSDVSSLSWAGKSLVEGGQGGSSCPEALS 701

  Fly  1967 LLGYA-------------ATPGAPLYHGTAEVYETLGDAP-----SQPGKPQLE--HIAEEVFRV 2011
            :||:|             |..|...|.|        ||||     |..|:..|.  |...::|..
Zfish   702 VLGWATFGGFGGGGGACSAGGGGGGYRG--------GDAPLLDDISADGQDGLSFVHPMGKIFLQ 758

  Fly  2012 TWTAARGNG-APIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTT 2075
            ...|...:| |.|.:| |.....::...:|                 .|:..::    |..|::.
Zfish   759 PLAAMESHGEAEIVVY-LNCSHCKTQSCKR-----------------DEDTKLI----LCLCDSD 801

  Fly  2076 E------LSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSL-------- 2126
            |      ::| ..:.||    |.:...:.|:|...|.      |..|.|.|  .|||
Zfish   802 EVLAPDNVTC-AGTKHS----LCQFINKHLQHNSSPL------VCPPLVVP--MGSLADGPPSLV 853

  Fly  2127 -----VLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRN 2186
                 :::.:....:::...|.|:..||  |..|.|.::..||            .:.:|..:|:
Zfish   854 FIMAGIVSTVVTGVVLTCASLTLIYYRK--KNHLHAVRIRLQS------------PEYKLSKIRS 904

  Fly  2187 RAFSTTLSD-----------ADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEE-PQRV 2239
               ||.::|           |.::.|.::....:.|||.||.||||||||||:...:.|. ..:|
Zfish   905 ---STIMTDYNPNYGYFGKAASLSELKEVPRKNITLLRALGHGAFGEVYEGQVLGMNGENTAMQV 966

  Fly  2240 AIKSLRKGASEFAEL--LQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAAR 2302
            |||:|.:..||..|:  |.||.:||.|.|:|||..:|:........:::|.|..||:.|:||..|
Zfish   967 AIKTLPEICSEQDEMDFLMEALIMSKFSHQNIVRCIGVSLQILPRFILLELMTGGDMKSFLRLNR 1031

  Fly  2303 ATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIG 2367
            ..:..    ::.||:.|||.|..|:|.||.|||:.||:|||:|.||||:|    .....|..|||
Zfish  1032 PRTNH----SSSLSMLELLHMARDIALGCRYLEENHFIHRDIAARNCLLT----CPGPDRVAKIG 1088

  Fly  2368 DFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARN 2432
            |||:|||||::.||||.|..:|||:||.||:.::|:||.::|.|:||||.|||.:||..||..:.
Zfish  1089 DFGMARDIYRASYYRKGGRAMLPVKWMPPEAFLEGIFTCKTDTWSFGVLLWEIFSLGYMPYPCKT 1153

  Fly  2433 NFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASAT 2497
            |.|||..|..|||:..|..|...:|.::..||:..|..||:|          :|.|.|....:..
Zfish  1154 NQEVLEFVTGGGRMDPPKSCPGPVYRIMTQCWQHCPEHRPNF----------TTILERINYCTQD 1208

  Fly  2498 ADTV-----VSCSRPEFKVRFDGQPLEEHREHNERPE 2529
            .|.:     |.|          |.|:||......||:
Zfish  1209 PDVINTPLPVEC----------GPPVEEEGGTVIRPD 1235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	18/130 (14%)
		FN3	1993..2111	CDD:238020	24/131 (18%)
		PTKc_c-ros	2213..2483	CDD:270640	122/272 (45%)
ltk	NP_001006661.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	635..671		8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1313..1334
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1389..1420
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1492..1530