DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and alk

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_001410894.1 Gene:alk / 563509 ZFINID:ZDB-GENE-031027-1 Length:1705 Species:Danio rerio


Alignment Length:428 Identity:163/428 - (38%)
Similarity:236/428 - (55%) Gaps:47/428 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly  2114 AEPFVSPEKRGSLVLAI-IAPAAIVSSCVLALVLVRKVQKRR---LRAKKLLQQSRPSIWSNL-- 2172
            |:|.:|     .|.|.: :..:|::::.:||:..|..:.:|:   |::.:|..||.....|.|  
Zfish  1023 AQPSLS-----HLALGLSVGTSALIAALLLAVSGVMIMYRRKHTELQSIQLELQSPDCKLSKLRA 1082

  Fly  2173 STLQTQQQLMAVRNRAF-STTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEG-QLKTEDSEE 2235
            ||:.|...    .|..| ..|.|..|:..:|:.|   :.|.|.||.||||||||| .:.......
Zfish  1083 STIMTDYN----PNYCFGGKTASVNDLKEVPRRN---ISLTRGLGHGAFGEVYEGLAVGIPGEPS 1140

  Fly  2236 PQRVAIKSLRKGASEFAEL--LQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYL 2298
            |.:||:|:|.:..||..||  |.||.::|.|.|:|||..:|:........:::|.|..|||.|:|
Zfish  1141 PMQVAVKTLPEVCSEQDELDFLMEALIISKFSHQNIVRCIGVSLQALPHFILLELMAGGDLKSFL 1205

  Fly  2299 RAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVT-ESTGSTDRRR 2362
            |..| ...:.|   :.|::.:||.:..|:|.||.|||:..|:|||:|.||||:| :..|     |
Zfish  1206 RETR-PRLEHP---SSLTMVDLLNIARDIARGCQYLEENQFIHRDIAARNCLLTCKGPG-----R 1261

  Fly  2363 TVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQP 2427
            ..||||||:|||||::.||||.|..:|||:||.||:.::|:||:::|.|:||||.|||.:||..|
Zfish  1262 VAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMP 1326

  Fly  2428 YAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQ 2492
            |.:|:|.|||..|..|||:..|..|...:|.::...|:..|.:||:|          ||.|.|..
Zfish  1327 YPSRSNQEVLEFVTNGGRMDPPKNCPGPVYRIMTQSWQHQPEDRPNF----------STILERID 1381

  Fly  2493 MASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPED 2530
            ......| ||:...|   |.:...|.||.|. ..||||
Zfish  1382 YCLQDPD-VVNVPLP---VEYGPIPEEEERV-PMRPED 1414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996
FN3 1993..2111 CDD:238020
PTKc_c-ros 2213..2483 CDD:270640 119/273 (44%)
alkNP_001410894.1 Heparin-binding region. /evidence=ECO:0000250|UniProtKB:Q9UM73 54..76
LDLa 449..475 CDD:197566
MAM 488..639 CDD:99706
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 842..892
EGF-like. /evidence=ECO:0000250|UniProtKB:Q9UM73 980..1016
FXa_inhibition 980..1012 CDD:464251
PTKc_ALK_LTK 1106..1382 CDD:270632 126/297 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1395..1499 10/24 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1505..1524
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1532..1557
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1588..1613
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1646..1681
Blue background indicates that the domain is not in the aligned region.

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