Protein Alignment sev and fer

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: XP_012818421.1
• Gene: fer / 549656
• XenbaseID: XB-GENE-1015488
• Length: 822
• Species: Xenopus tropicalis
• Alignment Length: 682
• Identity: 167/682 - (24%)
• Similarity: 278/682 - (40%)
• Gaps: 156/682 - (22%)

  Fly  1853 AHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLSL 1917
            |..:.|||.    :..|.|.:.|..:::.|.|................|:..||..|       :
 Frog   242 AVHKELETC----VEEINPSTEYENFIEKHRTEETREPDIEFDTSLLEEIENLQANE-------I 295

  Fly  1918 TWAG-TPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHG 1981
            .|.. |.|.|.|:   .:::.|:|.:......||.     :..::.:..|             ..
 Frog   296 MWNNLTADSLNSM---LKTATEELSQTQQSLLTKE-----EQLSKLEVNL-------------EE 339

  Fly  1982 TAEVYETLGDAP---SQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRR 2043
            :|...|...||.   ||  |..:|.:.:.:.::....::          |.|.:...|     ::
 Frog   340 SASTCEKKSDAVLLLSQ--KQAIEELKQSIEQLKCAESK----------LSAQKMLLD-----QK 387

  Fly  2044 RRRNSGGSLEQLPWAEEPVVV--EDQWLDFCNTTE-------------LSCIV---KSLHSSRLL 2090
            .::|.|        .|.|.||  |:.....|:..:             ::.|:   ||:..|..|
 Frog   388 IQQNEG--------KEPPPVVNYEEDARSVCSVDKKEKVSKFDTFRHSIAGIIRSPKSMLGSSSL 444

  Fly  2091 LFRVRA-------RSLEHGWGPYSEESERVAE--PFVSPE---KRGSLVLAIIAPAAIVSSCVLA 2143
            |..:.|       :...||..|..|..|.:.:  .|:..|   |.|..||::.:.:
 Frog   445 LDGISAIEKPLSEQDWYHGAIPRVEAQELLKQQGDFLVRESHGKPGEYVLSVFSDS--------- 500

  Fly  2144 LVLVRKVQKRRLRAKKLLQQSR------PSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALLP 2202
                   |:|....:....|.|      |:|...:....|.:|::         |.....:.|.|
 Frog   501 -------QRRHFIIQFADNQYRFEGTGFPTIPQLIEHHYTTKQVI---------TKKSGVVLLNP 549

  Fly  2203 QI-------NWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAEL--LQEA 2258
            .:       |...:.|...||.|.|||||:|.||     :...||:|:.::...:..::  |.||
 Frog   550 VVKDKKWILNHEDVTLGELLGKGNFGEVYKGTLK-----DKTPVAVKTCKEDLPQELKIKFLSEA 609

  Fly  2259 QLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAM 2323
            :::..:.|.|||.|:|:|...:.|.::||.:..||.||:||..:          ..:...:|...
 Frog   610 RILKQYDHANIVKLIGVCTQRQPIYIVMELVPGGDFLSFLRKKK----------DDMKTKQLAKF 664

  Fly  2324 CIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSD-YYRKEGEG 2387
            ..|.|:|.:|||..:.:|||||.|||||.|:       ..:||.|||::|.  :.| .|...|..
 Frog   665 SFDAASGMAYLESKNCIHRDLAARNCLVGEN-------NVLKISDFGMSRQ--EDDGIYSSSGLK 720

  Fly  2388 LLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMC 2452
            .:|::|.:||:|..|.::::||||:||:|.||..:||..||....|.:....|::|.|:..|..|
 Frog   721 QIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVEKGYRMSAPQNC 785

  Fly  2453 TEKLYSLLLLCWRTDPWERPSFRRCYNTLHAI 2484
            .|:::.::..||...|..||.|......|..|
 Frog   786 PEEVFRIMQKCWEYKPENRPKFSEMQKELSLI 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	9/37 (24%)
		FN3	1993..2111	CDD:238020	26/145 (18%)
		PTKc_c-ros	2213..2483	CDD:270640	93/272 (34%)
fer	XP_012818421.1	F-BAR_Fer	5..238	CDD:153370
		SH2_Fps_family	453..538	CDD:198224	19/100 (19%)
		Protein Kinases, catalytic domain	566..815	CDD:473864	92/272 (34%)