Protein Alignment sev and Alk

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_652600.1
• Gene: Alk / 53425
• FlyBaseID: FBgn0040505
• Length: 1701
• Species: Drosophila melanogaster
• Alignment Length: 1678
• Identity: 365/1678 - (21%)
• Similarity: 570/1678 - (33%)
• Gaps: 622/1678 - (37%)

  Fly  1220 WQPSTSGGNHSVSYRLLLEFGQRLQTLDLSTPFARLTQLPQAQLQLKISITPRTAWRSGDTTRVQ 1284
            | ||.|||....:.||      ..|.|.|..|     .||.|.........|..:.|.......|
  Fly    47 W-PSASGGKQLRNGRL------HEQPLPLPQP-----TLPVATQYEDYEAAPPGSRRDNKRRLAQ 99

  Fly  1285 LTTPPVAPSQPRRLRVFVERLATALQEANV--------------------SAVLRWDAPEQGQEA 1329
            :...|.:.:..||   .:|.|...|...:|                    |::.|.|...||
  Fly   100 MAQRPGSGNGGRR---GMESLRKELMNPSVGGPGGGISGGGSGYPSYSATSSIGRIDGLGQG--- 158

  Fly  1330 PMQALEYHISCWVGS-----ELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAAGAAS 1389
                        :||     .|:::||             ||         :.:||..|......
  Fly   159 ------------LGSADRYGALYDQLR-------------QP---------SGMAAMTAGPLGGP 189

  Fly  1390 HALHVAPEVQAVPRVLYANAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVELL 1454
            ::....|        |||..:     |...|:.|:     :.:..|..:  ::.|...:|....:
  Fly   190 YSTRFPP--------LYAGVD-----DQPKRSNRK-----NSISELYKL--KKALNQADEPAGGV 234

  Fly  1455 TH-------VPGSAPAKLARMRAEVLALAVDWIQRI------------VYWAELDATAPQAAIIY 1500
            ||       .|.||                |.:|.|            .|....||| |.:...|
  Fly   235 THGNFEGDPQPSSA----------------DPLQEIKDRIRDTSPNANTYAPHTDAT-PSSEYEY 282

  Fly  1501 RLDL-CNFE-------GKILQGERVWSTPR--GRLLKDLVALPQAQSLIWLEYEQGSPRNG---- 1551
            .|.: ||||       |....|.:|.:...  .|.|..|:..|.|.|:        ...||
  Fly   283 ELGVKCNFETPCSWTWGNYSDGFQVITGTELSKRNLTGLLPGPAADSI--------DDANGHFLY 339

  Fly  1552 -----SLRGRNLTDGSELEWATVQPL----IRLHAGSLEPGSETLNLVDNQGKLCVYDVARQLCT 1607
                 |.|..|||..   |::|....    :.:|...:..|...:             |...|.|
  Fly   340 ARVNPSSRPLNLTSP---EFSTTMEKCFLEVYMHQSDMSHGLSRV-------------VVELLHT 388

  Fly  1608 ASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAY--GRRRQQLEYTVELEPE-------EV 1663
            |.:......:||::               |:.|:.:.|  ||..:......|:.|:       .|
  Fly   389 AESSWVPAEILGDN---------------VRQWTRKVYRLGRVSRDFRIVFEVVPDLRVGQKGHV 438

  Fly  1664 RLLQAHNYQAYP----PKNCLLLPSSGGSLLKATDCEEQRCLLHLPMI-TASEDC---------- 1713
            .|........:|    .:.|      ..|.:|.|..:...| :|||.| ..:.||
  Fly   439 ALDNLRMVNCFPEGTKSEKC------STSQVKCTSSKVPVC-IHLPRICDITRDCDEAEDEQQSC 496

  Fly  1714 -PLPIPG------------VRYQLNLTLAKEPGSE-------EHDHGMEPL-----GQWLL-GAG 1752
             .:|..|            ...:..||.::..||.       :.||.|:.|     |.::| ...
  Fly   497 DKIPYGGRCDFEEDWCGWRDSGKTTLTWSRHTGSSPTHDTGPDGDHTMQHLQNNTSGYYMLVNMN 561

  Fly  1753 ESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATP-SPPRN-----FSVRVLS 1811
            :.:|.::......:..:.|:.|   |....|..|         ...| ||.||     |.:....
  Fly   562 QHMNNSEKNSIIGFASNAIMVS---KTFNPPPSV---------HGNPDSPYRNSCVVRFFIHQFG 614

  Fly  1812 PRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYS 1876
            .....::....|....|::..||.|..:..|.      :|...|        :.|..|.  |.|.
  Fly   615 KNPGSINLSVVEMKEKENITTTLWWSTKNQGS------DWMRAE--------YVLPNIT--SKYY 663

  Fly  1877 LWVQAHATPTKSNSSERLHVRSFAEL--------PE---LQLLE--LGPYS-------------- 1914
            |..:|           |:.:|.::::        ||   |.:.|  ||.|:
  Fly   664 LQFEA-----------RMGMRIYSDVAVDDFSLSPECFGLNIPEDHLGGYNYWDVRQNLKSPTYK 717

  Fly  1915 -------LSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCR------- 1965
                   |.||...|...:|..|.:|.::..:..:    .|....|..::.::.|:..
  Fly   718 DFEYTNYLELTTCDTRGMIGPSQAQCEAAYREQNK----THVLREVHVVEDQSSYKGMQKWKVPH 778

  Fly  1966 ----LLLGYAATPG---------------APL-YHGTAEVYETLGDAPSQPGKPQ---------- 2000
                .::...|:.|               |.| .|...|:|..:|    |.|:..
  Fly   779 EGHYTIIAKGASGGLGSGGVGSSRGSVAVAILELHKNEELYFLVG----QQGENACIKSMGVLKE 839

  Fly  2001 ----LEH---IAEEVFRVTWTAAR-----------GNGAPIALYNLEALQARS------------ 2035
                .:|   :|:..||......:           |.|:.:.|.|    ||::
  Fly   840 AGCGTDHDLDLAQYSFRSKQDMVKNIYIENGAGGGGGGSYVFLLN----QAKNEAVPLLVAGGGG 900

  Fly  2036 ----------DIRRRRRRR--RRNSGGSLEQLP-----------WAEEPVVVEDQWLDFCNTTEL 2077
                      |.:..::.:  :....|.:...|           |..:    |||.|.......|
  Fly   901 GLGIGQYIDEDFQHGQKAKPLQAPESGQINGEPLNKKTAGPGGGWRAK----EDQALSPTYGAAL 961

  Fly  2078 --------SCIVK------SLHSSRLLLFRVRARSLEHGWGPY---------------------- 2106
                    ||.|:      |:|              .||.|.:
  Fly   962 LQGGRGGHSCYVELADNGTSVH--------------RHGQGGFGGGGGGCNTGGGGGGYAGGDVY 1012

  Fly  2107 -SEESERVAEPFVSP-------------------------------------------------- 2120
             :|.:......::||
  Fly  1013 LTESNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIPAIEGCGCDYRCVALDEFRSKVRCIC 1077

  Fly  2121 -----------------EKRGS-----LVLAIIAPAAIVSSCVLALVLV------RKVQKRRLRA 2157
                             |:.|.     ||..::...|::..|:.||:.:      ||.|.:: |.
  Fly  1078 PDGWSLKRDNHTACEIREEAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQSKK-RH 1141

  Fly  2158 KKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSD--------------ADIALLPQINWSQ 2208
            |.|::|              ..||..:||....:.|::              .|:..|||:....
  Fly  1142 KMLVEQ--------------DLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARDS 1192

  Fly  2209 LKLLRFLGSGAFGEVYEGQLKTEDSEEPQR-VAIKSLRKGASEFAE--LLQEAQLMSNFKHENIV 2270
            |:|:..||.|||||||....:..|.:..:. ||:|:||:......|  .|:||.:|:.|.|.|:|
  Fly  1193 LQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMV 1257

  Fly  2271 CLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLE 2335
            .|:|:|||.:...:::|.:..|||..:||..|.|    |:..:.|::.:||...:|||.||.|:|
  Fly  1258 HLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNT----PERPSLLTMKDLLFCALDVAKGCRYME 1318

  Fly  2336 DMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLV 2400
            ...|:|||:|.||||::    |....|.|||.|||::||||:||||||.|:.:||::||.||:.:
  Fly  1319 SKRFIHRDIAARNCLLS----SKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFL 1379

  Fly  2401 DGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWR 2465
            ||:||:::|||:||:|.||:.:||:.||..::|.:|:..|..||||..|..|...:|.::..||.
  Fly  1380 DGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWN 1444

  Fly  2466 TDPWERPSFRRCYNTLHAISTD-----------LRRTQMASATADTVVSCSRP 2507
            ..|.:||:|......|.|.:.|           |..|  ||...|||:   ||
  Fly  1445 PTPEDRPTFITLLEHLTACTQDASIMNAPLPNILGPT--ASERDDTVI---RP 1492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495	18/106 (17%)
		fn3	1800..1891	CDD:394996	19/95 (20%)
		FN3	1993..2111	CDD:238020	30/217 (14%)
		PTKc_c-ros	2213..2483	CDD:270640	115/272 (42%)
Alk	NP_652600.1	MAM	288..447	CDD:99706	39/197 (20%)
		MAM	505..689	CDD:99706	39/222 (18%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	119/283 (42%)