DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sev and Alk

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_001261027.1 Gene:Alk / 53425 FlyBaseID:FBgn0040505 Length:1701 Species:Drosophila melanogaster


Alignment Length:1678 Identity:365/1678 - (21%)
Similarity:570/1678 - (33%) Gaps:622/1678 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  1220 WQPSTSGGNHSVSYRLLLEFGQRLQTLDLSTPFARLTQLPQAQLQLKISITPRTAWRSGDTTRVQ 1284
            | ||.|||....:.||      ..|.|.|..|     .||.|.........|..:.|.......|
  Fly    47 W-PSASGGKQLRNGRL------HEQPLPLPQP-----TLPVATQYEDYEAAPPGSRRDNKRRLAQ 99

  Fly  1285 LTTPPVAPSQPRRLRVFVERLATALQEANV--------------------SAVLRWDAPEQGQEA 1329
            :...|.:.:..||   .:|.|...|...:|                    |::.|.|...||   
  Fly   100 MAQRPGSGNGGRR---GMESLRKELMNPSVGGPGGGISGGGSGYPSYSATSSIGRIDGLGQG--- 158

  Fly  1330 PMQALEYHISCWVGS-----ELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAAGAAS 1389
                        :||     .|:::||             ||         :.:||..|......
  Fly   159 ------------LGSADRYGALYDQLR-------------QP---------SGMAAMTAGPLGGP 189

  Fly  1390 HALHVAPEVQAVPRVLYANAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVELL 1454
            ::....|        |||..:     |...|:.|:     :.:..|..:  ::.|...:|....:
  Fly   190 YSTRFPP--------LYAGVD-----DQPKRSNRK-----NSISELYKL--KKALNQADEPAGGV 234

  Fly  1455 TH-------VPGSAPAKLARMRAEVLALAVDWIQRI------------VYWAELDATAPQAAIIY 1500
            ||       .|.||                |.:|.|            .|....||| |.:...|
  Fly   235 THGNFEGDPQPSSA----------------DPLQEIKDRIRDTSPNANTYAPHTDAT-PSSEYEY 282

  Fly  1501 RLDL-CNFE-------GKILQGERVWSTPR--GRLLKDLVALPQAQSLIWLEYEQGSPRNG---- 1551
            .|.: ||||       |....|.:|.:...  .|.|..|:..|.|.|:        ...||    
  Fly   283 ELGVKCNFETPCSWTWGNYSDGFQVITGTELSKRNLTGLLPGPAADSI--------DDANGHFLY 339

  Fly  1552 -----SLRGRNLTDGSELEWATVQPL----IRLHAGSLEPGSETLNLVDNQGKLCVYDVARQLCT 1607
                 |.|..|||..   |::|....    :.:|...:..|...:             |...|.|
  Fly   340 ARVNPSSRPLNLTSP---EFSTTMEKCFLEVYMHQSDMSHGLSRV-------------VVELLHT 388

  Fly  1608 ASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAY--GRRRQQLEYTVELEPE-------EV 1663
            |.:......:||::               |:.|:.:.|  ||..:......|:.|:       .|
  Fly   389 AESSWVPAEILGDN---------------VRQWTRKVYRLGRVSRDFRIVFEVVPDLRVGQKGHV 438

  Fly  1664 RLLQAHNYQAYP----PKNCLLLPSSGGSLLKATDCEEQRCLLHLPMI-TASEDC---------- 1713
            .|........:|    .:.|      ..|.:|.|..:...| :|||.| ..:.||          
  Fly   439 ALDNLRMVNCFPEGTKSEKC------STSQVKCTSSKVPVC-IHLPRICDITRDCDEAEDEQQSC 496

  Fly  1714 -PLPIPG------------VRYQLNLTLAKEPGSE-------EHDHGMEPL-----GQWLL-GAG 1752
             .:|..|            ...:..||.::..||.       :.||.|:.|     |.::| ...
  Fly   497 DKIPYGGRCDFEEDWCGWRDSGKTTLTWSRHTGSSPTHDTGPDGDHTMQHLQNNTSGYYMLVNMN 561

  Fly  1753 ESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATP-SPPRN-----FSVRVLS 1811
            :.:|.::......:..:.|:.|   |....|..|         ...| ||.||     |.:....
  Fly   562 QHMNNSEKNSIIGFASNAIMVS---KTFNPPPSV---------HGNPDSPYRNSCVVRFFIHQFG 614

  Fly  1812 PRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYS 1876
            .....::....|....|::..||.|..:..|.      :|...|        :.|..|.  |.|.
  Fly   615 KNPGSINLSVVEMKEKENITTTLWWSTKNQGS------DWMRAE--------YVLPNIT--SKYY 663

  Fly  1877 LWVQAHATPTKSNSSERLHVRSFAEL--------PE---LQLLE--LGPYS-------------- 1914
            |..:|           |:.:|.::::        ||   |.:.|  ||.|:              
  Fly   664 LQFEA-----------RMGMRIYSDVAVDDFSLSPECFGLNIPEDHLGGYNYWDVRQNLKSPTYK 717

  Fly  1915 -------LSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCR------- 1965
                   |.||...|...:|..|.:|.::..:..:    .|....|..::.::.|:..       
  Fly   718 DFEYTNYLELTTCDTRGMIGPSQAQCEAAYREQNK----THVLREVHVVEDQSSYKGMQKWKVPH 778

  Fly  1966 ----LLLGYAATPG---------------APL-YHGTAEVYETLGDAPSQPGKPQ---------- 2000
                .::...|:.|               |.| .|...|:|..:|    |.|:..          
  Fly   779 EGHYTIIAKGASGGLGSGGVGSSRGSVAVAILELHKNEELYFLVG----QQGENACIKSMGVLKE 839

  Fly  2001 ----LEH---IAEEVFRVTWTAAR-----------GNGAPIALYNLEALQARS------------ 2035
                .:|   :|:..||......:           |.|:.:.|.|    ||::            
  Fly   840 AGCGTDHDLDLAQYSFRSKQDMVKNIYIENGAGGGGGGSYVFLLN----QAKNEAVPLLVAGGGG 900

  Fly  2036 ----------DIRRRRRRR--RRNSGGSLEQLP-----------WAEEPVVVEDQWLDFCNTTEL 2077
                      |.:..::.:  :....|.:...|           |..:    |||.|.......|
  Fly   901 GLGIGQYIDEDFQHGQKAKPLQAPESGQINGEPLNKKTAGPGGGWRAK----EDQALSPTYGAAL 961

  Fly  2078 --------SCIVK------SLHSSRLLLFRVRARSLEHGWGPY---------------------- 2106
                    ||.|:      |:|              .||.|.:                      
  Fly   962 LQGGRGGHSCYVELADNGTSVH--------------RHGQGGFGGGGGGCNTGGGGGGYAGGDVY 1012

  Fly  2107 -SEESERVAEPFVSP-------------------------------------------------- 2120
             :|.:......::||                                                  
  Fly  1013 LTESNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIPAIEGCGCDYRCVALDEFRSKVRCIC 1077

  Fly  2121 -----------------EKRGS-----LVLAIIAPAAIVSSCVLALVLV------RKVQKRRLRA 2157
                             |:.|.     ||..::...|::..|:.||:.:      ||.|.:: |.
  Fly  1078 PDGWSLKRDNHTACEIREEAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQSKK-RH 1141

  Fly  2158 KKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSD--------------ADIALLPQINWSQ 2208
            |.|::|              ..||..:||....:.|::              .|:..|||:....
  Fly  1142 KMLVEQ--------------DLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARDS 1192

  Fly  2209 LKLLRFLGSGAFGEVYEGQLKTEDSEEPQR-VAIKSLRKGASEFAE--LLQEAQLMSNFKHENIV 2270
            |:|:..||.|||||||....:..|.:..:. ||:|:||:......|  .|:||.:|:.|.|.|:|
  Fly  1193 LQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMV 1257

  Fly  2271 CLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLE 2335
            .|:|:|||.:...:::|.:..|||..:||..|.|    |:..:.|::.:||...:|||.||.|:|
  Fly  1258 HLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNT----PERPSLLTMKDLLFCALDVAKGCRYME 1318

  Fly  2336 DMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLV 2400
            ...|:|||:|.||||::    |....|.|||.|||::||||:||||||.|:.:||::||.||:.:
  Fly  1319 SKRFIHRDIAARNCLLS----SKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFL 1379

  Fly  2401 DGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWR 2465
            ||:||:::|||:||:|.||:.:||:.||..::|.:|:..|..||||..|..|...:|.::..||.
  Fly  1380 DGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWN 1444

  Fly  2466 TDPWERPSFRRCYNTLHAISTD-----------LRRTQMASATADTVVSCSRP 2507
            ..|.:||:|......|.|.:.|           |..|  ||...|||:   ||
  Fly  1445 PTPEDRPTFITLLEHLTACTQDASIMNAPLPNILGPT--ASERDDTVI---RP 1492

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470
FN3 826..921 CDD:238020
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495 18/106 (17%)
FN3 1799..1897 CDD:238020 21/103 (20%)
FN3 1993..2111 CDD:238020 30/217 (14%)
Pkinase_Tyr 2209..2481 CDD:285015 116/274 (42%)
PTKc_c-ros 2213..2483 CDD:270640 115/272 (42%)
AlkNP_001261027.1 MAM 288..450 CDD:279023 39/200 (20%)
MAM 288..447 CDD:99706 39/197 (20%)
MAM 505..691 CDD:279023 40/224 (18%)
MAM 505..689 CDD:99706 39/222 (18%)
PTKc_ALK_LTK 1186..1462 CDD:270632 119/283 (42%)
TyrKc 1193..1460 CDD:197581 116/274 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45455279
Domainoid 1 1.000 165 1.000 Domainoid score I1208
eggNOG 1 0.900 - - E2759_KOG1095
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D27151at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
65.850

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