Protein Alignment sev and LOC4578387

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: XP_061510796.1
• Gene: LOC4578387 / 4578387
• VectorBaseID: AGAMI1_010804
• Length: 1482
• Species: Anopheles gambiae
• Alignment Length: 1481
• Identity: 322/1481 - (21%)
• Similarity: 540/1481 - (36%)
• Gaps: 425/1481 - (28%)

  Fly  1297 RLRVFVERLATALQEANVSAV------LRWDAPEQGQEAPMQALEYHISCWVGSELHEELRLNQS 1355
            |.|:|:..|..|.....|.|.      ||:....|.:..|.:|....:..:..|..::.:
Mosquito    24 RFRLFILLLLYASTIGTVGAFKQPLSKLRYLEHFQYECFPPEAKANLVPRFASSNQNDSI----- 83

  Fly  1356 ALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVAPEVQAVPRVLYAN---AEFIGELDL 1417
                   .||..:.|..|:.:||.|.            :..||..     |.|   .|:..||.:
Mosquito    84 -------SLQVSRRYTHQIVSRVYAI------------LLREVLG-----YGNVKMVEYSDELPI 124

  Fly  1418 DTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVEL-------LTHVPG--------SAPAKLAR 1467
            ..:.|.|:.||   :|||....||    |.:..::|       ..::||        :.|.:...
Mosquito   125 LEKERIRMFHT---LEHLTSYGGE----WPDPTIDLEVWLLSDYHYIPGEIREAGAIANPGRFGL 182

  Fly  1468 MRAEVLALAVD-WIQRIVYW---------------AELDATAPQAAIIYRL------DLCNFEGK 1510
            ...:.|....| :.:.::|.               .:.|.:.|....|||.      :.|:..|.
Mosquito   183 FLPKALIRKEDNFPKPLIYTLFQEDSNNHRYYDFIKKFDISQPVLESIYRYAERKCDNDCDDYGM 247

  Fly  1511 IL-----QGERV-------WSTPRGRLLKDLVALPQAQSLIWLEYEQGSPRNGSLRGRNLTDGSE 1563
            .:     ||.:.       :...| .|::.:..:.....:|||                   |..
Mosquito   248 FVPTQCAQGVKCALVLAPHYEDTR-FLVQHITEMNFQLKVIWL-------------------GDR 292

  Fly  1564 LEWATVQPLIRLHAGSLEPGSE------TLNLVDNQGKLCVYDVARQLCTASALRAQLNLLGEDS 1622
            |:.. ::.|:..:.|..:.|.:      |.:.|.|...:....:....|             ||.
Mosquito   293 LKLG-IRQLMNTYGGDRKNGKKFLVFHWTPSEVINTRTMEYVPITMPRC-------------EDM 343

  Fly  1623 IAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYT----VELEPEEVRLLQAHN-YQAYPPKNCLLL 1682
            ||   :.|:|..|.:.. .::.||::.::.:|.    :....||..:.|..: |.|:.|: .:.:
Mosquito   344 IA---SNDTGCKYEMTP-LLKYYGKKFREADYAFNSLILTHFEEQSMQQIFDLYDAHEPE-IMRV 403

  Fly  1683 PSSG-------GSLLKATDCEEQRCLLHLPMITASEDCPLPIPGVRYQLNLTLAKEPGSEEHDHG 1740
            ...|       ..:.....||..|         |.|.     ..:|::     .::|..|.:..|
Mosquito   404 REEGDPDQTRVAEIYNQIACEWMR---------AQES-----TWMRWK-----PEDPKEEVYIGG 449

  Fly  1741 MEPL---GQWLLGAGESLNLTD--------LLPFTRY-----------RVSGILSSFYQKKLALP 1783
            :.||   |...||...:..|..        :||  .|           |...::.||....:...
Mosquito   450 IFPLTGMGPSYLGIAPAALLAQDHINGNGTILP--NYELTVQQNDGQCRADTVMKSFISYYIQQT 512

  Fly  1784 TL--VLAPLELLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQ 1846
            .:  :|.|....|........::|.:.|:| ...|.::|      |:...|...::  ..|||
Mosquito   513 RMIGILGPACSETVEPIAGVSKHFRMAVIS-YSAEGAFL------SDREKYPFFFR--TIGEN-- 566

  Fly  1847 DRREWE-AHERRLETAGTHRLTGI-KPGSGYSLWVQAHATPTKSNSSERLHVRSF------AELP 1903
              |::| .:.:.|:.....|:..: :.|...:.::....|..|..|.|.:..:.|      .|:.
Mosquito   567 --RQYEHVYAQLLQRMNWRRVAALTEDGQKATEYISYMETLLKERSIELISNKKFPRDRTDTEMN 629

  Fly  1904 ELQLLELGPYSLSLTWAGTPDPLGSLQLECRS-SAEQLRRN--------------------VAGN 1947
            : .||:|...|..:..|...|.:..: :.|.: ..|....|                    ..|.
Mosquito   630 Q-YLLDLKSKSAKIIIADVDDKVARV-IMCEAYKLEMTAENGYIWFLPIWLSNVWNFSSEVPGGE 692

  Fly  1948 HTKMVVEPLQP-RTRYQC------RLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIA 2005
            :....|.|... ||...|      |.:.|:.:...|| |.....:.:....|..:..|
Mosquito   693 NGATAVPPTSTNRTTRGCTNSELLRAMNGHFSLSHAP-YADDDSILDVNRSATVRDWK------- 749

  Fly  2006 EEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWA----------EE 2060
             :.:.|:          ::.||..|    ||.           .|......|.          |:
Mosquito   750 -QAYNVS----------LSEYNYMA----SDY-----------AGFAYDAVWVYALAFDRLLRED 788

  Fly  2061 PVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWG--PYSEESERVA--------- 2114
            |..:.|              :.|.|:::.|:..:|....:...|  .::|...|..
Mosquito   789 PSYISD--------------LHSRHTTKRLMELIRETDFQGVTGRIKFNEAGSRYTIVNVLQFVN 839

  Fly  2115 ---------EPFVS-PEKR---GSLVL---AII------------APAAIVSSCV---------L 2142
                     .|.:| |:.:   |.|||   ||:            .|...:.|.|         :
Mosquito   840 GTANIVGHFTPNISEPDYKLLGGDLVLNESAIVWMTRDGHIPDDGTPVCALESFVRIFGISCDEV 904

  Fly  2143 ALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVR-NRAFSTT---LSDADIALLPQ 2203
            .::::..|                ||.|.|...........|| :|...|:   |....|.||.|
Mosquito   905 TMIVISMV----------------SIISILILSVASFLFWKVRYDRKMQTSAKYLQKLGIDLLSQ 953

  Fly  2204 IN--------W----SQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGAS--EFAEL 2254
            .:        |    .::.:.|.||.||||.||.|:.:..| |....||:|:|:.|::  :..:.
Mosquito   954 TSGPVNTLDKWEIPKDRVVINRRLGEGAFGTVYGGEAQIGD-EGWTAVAVKTLKVGSTTEDKVDF 1017

  Fly  2255 LQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSE 2319
            |.||:.|..|.|.|||.|:|:|..:|.:..:||.|..|||.:||.|.|.....:....:.:|...
Mosquito  1018 LSEAEAMKRFDHNNIVRLLGVCLQSEPVYTVMEFMLYGDLKTYLLARRHLVNSKQSEDSDISNKR 1082

  Fly  2320 LLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKE 2384
            |..|.:||:...|||.:..:||||:|||||:|       :.:|.||:||||:||..:::||||..
Mosquito  1083 LTMMALDVSRALSYLAEQKYVHRDVACRNCMV-------NAQRVVKLGDFGMARPTFENDYYRFN 1140

  Fly  2385 GEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQP 2449
            ..|:||||||:||||..|:||..||||::|||.:||:|.|..|:....|.:||.|:|.|..:..|
Mosquito  1141 RRGMLPVRWMAPESLGLGIFTPASDVWSYGVLLYEIITFGSFPFQGLTNNQVLEHLKNGNTITIP 1205

  Fly  2450 PMCTEKLYSLLLLCWRTDPWERPS----------FRRCYNTLHAISTDLRRTQMASATADTVVSC 2504
            .....:|..|:..||..|..:|||          :.|..|.  .:...|...:|....:|
Mosquito  1206 AGVKPQLEGLMKACWNQDYKKRPSASEVSEFISNYPRLLNP--CLDVPLASVEMVDTGSD----- 1263

  Fly  2505 SRPEFKVRFDGQP-LEEHREHNERPEDENLTLREVPLKDKQLYANEGVSRL 2554
                   :|:..| |.::::.:::| ..:|.:...|:.|    .|.|.:.:
Mosquito  1264 -------QFELLPGLRKYKDESQQP-TADLLVGTQPMND----LNNGYNNV 1302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495	16/82 (20%)
		fn3	1800..1891	CDD:394996	17/92 (18%)
		FN3	1993..2111	CDD:238020	18/129 (14%)
		PTKc_c-ros	2213..2483	CDD:270640	114/281 (41%)
LOC4578387	XP_061510796.1	None