Protein Alignment sev and MST1R

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: XP_005265227.2
• Gene: MST1R / 4486
• HGNCID: 7381
• Length: 1401
• Species: Homo sapiens
• Alignment Length: 1741
• Identity: 381/1741 - (21%)
• Similarity: 574/1741 - (32%)
• Gaps: 609/1741 - (34%)

  Fly  1033 ELLPVFEANFLAL-----DPRQGHLYYATSSQLSRHGSTPDEAVTY----YRVNGLEGSIASFVL 1088
            ||||....:||.|     .|..|..:....:.   :.::.|..|.|    :...||..::.::..
Human     2 ELLPPLPQSFLLLLLLPAKPAAGEDWQCPRTP---YAASRDFDVKYVVPSFSAGGLVQAMVTYEG 63

  Fly  1089 DTQQDQLFWLVKGSGALRLYRAPLTAGGDSLQMIQQI--------------------KGVFQAVP 1133
            |..:..:|..::.    ||:     ..|..|:.:|.:                    .|......
Human    64 DRNESAVFVAIRN----RLH-----VLGPDLKSVQSLATGPAGDPGCQTCAACGPGPHGPPGDTD 119

  Fly  1134 DSLQLLRP-LGALLWLERS--GR--------RARLVRLAAPLDVMEL--PTPDQ-----ASP--- 1177
            ..:.:|.| |.||:....|  ||        :...|.||||..:...  ..||.     |||
Human   120 TKVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVASPLGT 184

  Fly  1178 ---------------ASALQLLDPQPLPPRD--------------EGVIPMTVLPDSVRLDDGHW 1213
                           ||:|.........||.              .|.:.::|||
Human   185 RVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVALSVLP---------- 239

  Fly  1214 DDFHVRWQPSTSGGNHSVSYRLLLEFGQRLQT----LDLSTPFARLTQLPQAQLQLKISITPRTA 1274
                          .|.|||.  :|:.....|    ..|:...|.:|..|.| |..:::....|.
Human   240 --------------KHLVSYS--IEYVHSFHTGAFVYFLTVQPASVTDDPSA-LHTRLARLSATE 287

  Fly  1275 WRSGDTTRVQLTTPPVAPSQPRRLRVFVERLATALQEANVSAVLRWDAPEQGQEAPMQALEYHIS 1339
            ...||...:.|.. ..||.:.||                       .|||.||..|:..:.:  |
Human   288 PELGDYRELVLDC-RFAPKRRRR-----------------------GAPEGGQPYPVLRVAH--S 326

  Fly  1340 CWVGSELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATG--AAAGAASHALHVAPEVQAVP 1402
            ..||::|..||.:.:..                :|...|..||  ...|...:::..|..:..:.
Human   327 APVGAQLATELSIAEGQ----------------EVLFGVFVTGKDGGPGVGPNSVVCAFPIDLLD 375

  Fly  1403 RVLYANAEFIGELDLDTRNRRRLVHTASP--VEHLVGIEGEQRLLWVNEHVELLTHVPGSAPAKL 1465
            .::....|...|..:....||.|....||  ..:..|:|.    |..|....   |.|....:..
Human   376 TLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPGLEA----LSPNTSCR---HFPLLVSSSF 433

  Fly  1466 ARMRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRLD------LCNFEGKILQGERVWSTPRGR 1524
            :|         ||....:     |......|..:.|||      :...:|:|||.|.|
Human   434 SR---------VDLFNGL-----LGPVQVTALYVTRLDNVTVAHMGTMDGRILQVELV------- 477

  Fly  1525 LLKDLVALPQAQSLIWLEY-------EQGSP--RNGSLRGRNLTDGSELEWATVQPLIRLHAGSL 1580
                       :||.:|.|       :.|.|  |:.|..|.:|...|
Human   478 -----------RSLNYLLYVSNFSLGDSGQPVQRDVSRLGDHLLFAS------------------ 513

  Fly  1581 EPGSETLNLVDNQGKLCVYDVARQLCTASALRAQLNLLG---EDSIAGQLAQDSGYLYAVKNWSI 1642
              |.:... |..||..|     |...|........:.:|   ..::.||..:..|      :|.
Human   514 --GDQVFQ-VPIQGPGC-----RHFLTCGRCLRAWHFMGCGWCGNMCGQQKECPG------SWQ- 563

  Fly  1643 RAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCLLLPSSG---GSLLKATDCEEQRCLLH- 1703
                                    |.|    .|||.....|.||   || .:.|.| .....||
Human   564 ------------------------QDH----CPPKLTEFHPHSGPLRGS-TRLTLC-GSNFYLHP 598

  Fly  1704 ---LP----MITASEDCPLPIPGVRYQLNLTLAKEPGSEEHDHGMEPLGQWLLG-AGESLNLTDL 1760
               :|    .:|..:....|:|....:|. .:.::...||.:..:||||...:| ...||.:|::
Human   599 SGLVPEGTHQVTVGQSPCRPLPKDSSKLR-PVPRKDFVEEFECELEPLGTQAVGPTNVSLTVTNM 662

  Fly  1761 LPFTRYRVSG--ILSSFYQKKLALPTLV-LAPLELLTASATPSPPRNFSVRVLSPR--------- 1813
            .|...:||.|  :|..|   ....|.|: :.||....|..|.......|:.|.:.|
Human   663 PPGKHFRVDGTSVLRGF---SFMEPVLIAVQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVNGTEC 724

  Fly  1814 ------ELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPG 1872
                  |.::....|......||..:|    ::.|..|.....::..|..:       :..|.|.
Human   725 LLARVSEGQLLCATPPGATVASVPLSL----QVGGAQVPGSWTFQYREDPV-------VLSISPN 778

  Fly  1873 SGYSLWVQAHATPTKSNSSERLH-VRSF-------------AELPELQLLELGPYSLSLTWAGTP 1923
            .||   :.:|.|....:.:...| |.||             .:|||.||..|..|.:.
Human   779 CGY---INSHITICGQHLTSAWHLVLSFHDGLRAVESRQCERQLPEQQLCRLPEYVVR------- 833

  Fly  1924 DPLGSLQLECRSSAEQLRRNVAGN----------------------HTKMV-VEPLQP-----RT 1960
            ||.|.               ||||                      |.... :.||:|     :.
Human   834 DPQGW---------------VAGNLSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKF 883

  Fly  1961 RY-------QCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARG 2018
            .|       .|   :|...|.|     |.:..:|..||....|..|.|: :.::
Human   884 EYIGLGAVADC---VGINVTVG-----GESCQHEFRGDMVVCPLPPSLQ-LGQD----------- 928

  Fly  2019 NGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKS 2083
             |||:.:                                                     |:...
Human   929 -GAPLQV-----------------------------------------------------CVDGE 939

  Fly  2084 LHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRG---SLVLAIIAP-----AAIVSSC 2140
            .|    :|.||                       |.|...|   |.:|.|:.|     ||:.::.
Human   940 CH----ILGRV-----------------------VRPGPDGVPQSTLLGILLPLLLLVAALATAL 977

  Fly  2141 VLALVLVRK--VQKRRLRAKKLLQQSR-----PSIWSN--------LSTLQTQQQLMAVRNRAFS 2190
            |.:....||  |....|.....|.|:.     |.::|.        |..:........|...:||
Human   978 VFSYWWRRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSGLALPAIDGLDSTTCVHGASFS 1042

  Fly  2191 TT---------------LSDADIALLPQINWSQLKLL-----------RFLGSGAFGEVYEGQLK 2229
            .:               |.|.|.|||.::.    .:|           |.:|.|.||.||.|:.
Human  1043 DSEDESCVPLLRKESIQLRDLDSALLAEVK----DVLIPHERVVTHSDRVIGKGHFGVVYHGEY- 1102

  Fly  2230 TEDSEEPQRVAIKSLRKGASEFAEL---LQEAQLMSNFKHENIVCLVGICFDTESI-SLIMEHME 2290
            .:.::...:.|||||.: .:|..::   |:|..||....|.|::.|:||....|.: .:::.:|.
Human  1103 IDQAQNRIQCAIKSLSR-ITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMC 1166

  Fly  2291 AGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTEST 2355
            .||||.::|:          |....::.:|::..:.||.|..||.:..|||||||.|||::.||.
Human  1167 HGDLLQFIRS----------PQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESF 1221

  Fly  2356 GSTDRRRTVKIGDFGLARDIYKSDYY--RKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCW 2418
                   |||:.||||||||...:||  ::.....|||:||:.|||....|||:||||:||||.|
Human  1222 -------TVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLW 1279

  Fly  2419 EILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHA 2483
            |:||.|..||...:.|::...:.:|.||.||..|.:.||.::..||..||..||:||
Human  1280 ELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFR-------- 1336

  Fly  2484 ISTDLRRTQMASATADTVVSCSRPEFKVRFDGQ-----PLEEHREHNERPE 2529
                     :.....:.:||....:..|:....     |...| |.|.|||
Human  1337 ---------VLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSH-EMNVRPE 1377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399	19/93 (20%)
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495	15/81 (19%)
		fn3	1800..1891	CDD:394996	17/105 (16%)
		FN3	1993..2111	CDD:238020	11/117 (9%)
		PTKc_c-ros	2213..2483	CDD:270640	105/275 (38%)
MST1R	XP_005265227.2	Sema_RON	27..523	CDD:200540	118/636 (19%)
		PSI	526..568	CDD:396154	10/81 (12%)
		IPT_plexin_repeat1	569..683	CDD:238585	32/119 (27%)
		IPT_plexin_repeat2	684..768	CDD:238584	16/87 (18%)
		IPT	769..860	CDD:214657	24/122 (20%)
		PTKc_Met_Ron	1087..1348	CDD:270649	106/296 (36%)