DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sev and Ret

DIOPT Version :9

Sequence 1:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster
Sequence 2:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	427	Identity:	136/427 - (31%)
Similarity:	209/427 - (48%)	Gaps:	96/427 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  2105 PYSEESERVAEPFVSPEKRGS---------LVLAIIAPAA---------IVSSCVLALVLV---- 2147
            |...::|..|||.:. .:||:         ::|.::..|.         .|.:|.|..||:
  Fly   650 PRKRKNETEAEPLLG-VRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCL 713

  Fly  2148 ----RKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALLP------ 2202
                ||:.:|||..:.:...|:.::..:                      ...|.||:|
  Fly   714 LIAQRKMLQRRLGKQSMTTSSKQALPES----------------------GGGDFALMPLQSGFR 756

  Fly  2203 ----QINW----SQLKLLRFLGSGAFGEVYEGQLKTEDSEEP--QRVAIKSLRKGAS--EFAELL 2255
                ...|    .:|:|...||.|.||:|.:| ..||.:..|  ..||:|.|:||::  |:..||
  Fly   757 FESGDAKWEFPREKLQLDTVLGEGEFGQVLKG-FATEIAGLPGITTVAVKMLKKGSNSVEYMALL 820

  Fly  2256 QEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSE- 2319
            .|.||:....|.|::.|:|.|..:|:..||:|:...|.|.||||.:|...      .||:..::
  Fly   821 SEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIE------CAGVDFADG 879

  Fly  2320 --------LLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIY 2376
                    :|.....:..|.:||.::..||||||.||.|:.:.       :..||.||||.||:|
  Fly   880 VEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADG-------KICKISDFGLTRDVY 937

  Fly  2377 KSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPY---AARNNFEVLA 2438
            :.|.|.|.....:||:||:||||.|.::|::||||:|||||||::|||..||   |.:|.:.:|
  Fly   938 EDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLL- 1001

  Fly  2439 HVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFR 2475
              |.|.|:.:|..|:|.:||::..||..:|..||||:
  Fly  1002 --KTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFK 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020
		FN3	1993..2111	CDD:238020	1/5 (20%)
		Pkinase_Tyr	2209..2481	CDD:285015	111/283 (39%)
		PTKc_c-ros	2213..2483	CDD:270640	109/279 (39%)
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	111/284 (39%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	111/283 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455269
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940