DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and LTK

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_002335.2 Gene:LTK / 4058 HGNCID:6721 Length:864 Species:Homo sapiens


Alignment Length:877 Identity:237/877 - (27%)
Similarity:338/877 - (38%) Gaps:280/877 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1788 APLELLTASATPSPPR-NFSVRVLSPRE------LEVSWL----------PPEQLRSESVYYTLH 1835
            :||.|  ||.:|..|: :....:|.|..      .|.|||          .|.|.:.:..|    
Human    32 SPLPL--ASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAY---- 90

  Fly  1836 WQQELDGENVQDRREWEAHERRLETAG-THRLTGIK----PGSGYSLWVQAHATPTK--SNSSER 1893
                 .|.:|            :.|.| ..:|.|::    ||.|..|.....|...|  .|...|
Human    91 -----AGTSV------------VVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSR 138

  Fly  1894 LH---VRSFAEL----------------------PELQLLELGPYSL---------------SLT 1918
            .|   |.:...|                      ||.||:.||....               |..
Human   139 AHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCLGESRAVEEHAAMDGSEGVPGSRR 203

  Fly  1919 WAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEP------------LQPRTRYQCRLLLGYA 1971
            |||.....|......|..|.:|             ||            |:||.|         .
Human   204 WAGGGGGGGGATYVFRVRAGEL-------------EPLLVAAGGGGRAYLRPRDR---------G 246

  Fly  1972 ATPGAPLYHGTAEVYETLGDAPSQPGK----------------PQL-----------EHIAEEVF 2009
            .|..:|      |..|...:||...|:                ||.           :..:|...
Human   247 RTQASP------EKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGCSEAWA 305

  Fly  2010 RVTWTAA----RGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLD 2070
            .:.|.||    .|.||..|                      ..||...:...|.|   .::.|.|
Human   306 TLGWAAAGGFGGGGGACTA----------------------GGGGGGYRGGDASE---TDNLWAD 345

  Fly  2071 FCNTTELSCIVKSLHSSRLLLFRVRARSLEHG-------------------WGPYSEESERVAEP 2116
            ..:.      |..:|.|..|..:..|.:..||                   |     ::|.....
Human   346 GEDG------VSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQW-----QAELQLAE 399

  Fly  2117 FVSPE----------------KRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSR 2165
            .:.||                ..|.|||.:    |:|::..|:|::|..|       ..|::|.:
Human   400 CLCPEGMELAVDNVTCMDLHKPPGPLVLMV----AVVATSTLSLLMVCGV-------LILVKQKK 453

  Fly  2166 PSIWSNLSTLQ---TQQQLMAVRNRAFSTTLSD--ADIALLPQINW-----------SQLKLLRF 2214
               |..|..::   .:.:|..:|..|..|..:.  ..:.|.|..:|           :.:.|||.
Human   454 ---WQGLQEMRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRA 515

  Fly  2215 LGSGAFGEVYEG-QLKTEDSEEPQRVAIKSLRKGASEFAEL--LQEAQLMSNFKHENIVCLVGIC 2276
            ||.||||||||| .:.......|.:||||:|.:..|...||  |.||.::|.|:|:|||..||:.
Human   516 LGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLS 580

  Fly  2277 FDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVH 2341
            .......:::|.|..||:.|:||.:|....| |.|   |.:.:||.:..|:|.||.|||:.||:|
Human   581 LRATPRLILLELMSGGDMKSFLRHSRPHLGQ-PSP---LVMRDLLQLAQDIAQGCHYLEENHFIH 641

  Fly  2342 RDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTT 2406
            ||:|.||||::.:..|    |..||||||:|||||::.|||:....||||:||.||:.::|:||:
Human   642 RDIAARNCLLSCAGPS----RVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTS 702

  Fly  2407 QSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWER 2471
            ::|.|:||||.|||.:||..||..|.|.|||..|..|||:..|..|...:|.::..||:.:|..|
Human   703 KTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELR 767

  Fly  2472 PSFRRCYNTLHAISTDLRRTQMASATADTVVS 2503
            |||          ::.|.|.|..:...|.:.|
Human   768 PSF----------ASILERLQYCTQDPDVLNS 789

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996 23/114 (20%)
FN3 1993..2111 CDD:238020 26/167 (16%)
PTKc_c-ros 2213..2483 CDD:270640 122/272 (45%)
LTKNP_002335.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 30..64 9/33 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..297 13/72 (18%)
PTKc_ALK_LTK 503..779 CDD:270632 126/293 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 790..830 237/877 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 842..864
Blue background indicates that the domain is not in the aligned region.

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