DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sev and btl

DIOPT Version :9

Sequence 1:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	1120	Identity:	253/1120 - (22%)
Similarity:	402/1120 - (35%)	Gaps:	322/1120 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1526 LKDLVALPQAQSLIWLEYEQGSPRNGSLRGRNLTDGSELEWATVQPLIRLHAGSLEPGSETLNLV 1590
            |:|..|||::....       .|.|.|...:.|....:....|...|.:|:...::|.::.:|:
  Fly   120 LEDAPALPESDLFF-------QPLNESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPDAKGVNI- 176

  Fly  1591 DNQGKLCVYDVARQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYT 1655
                              |.|.....:||.   .|::        .:|.||:            |
  Fly   177 ------------------SWLHNDTQILGG---RGRI--------KLKRWSL------------T 200

  Fly  1656 V-ELEPEEVRLLQAHNYQAYPPKNCLLLPSSGGSLLKATDCEEQRCL----LHLPMITASEDCPL 1715
            | :|:||:     |.:|      :|.|             |.||.|.    ..|.:|:.....|:
  Fly   201 VGQLQPED-----AGSY------HCEL-------------CVEQDCQRSNPTQLEVISRKHTVPM 241

  Fly  1716 PIPGVRYQLNLTLAKEPGSE--EHDHGMEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQK 1778
            ..||.....::.|......|  ..|..:||...| |..|.:.|:.|||...|            :
  Fly   242 LKPGYPRNTSIALGDNVSIECLLEDSALEPKITW-LHKGNADNIDDLLQRLR------------E 293

  Fly  1779 KLALPTLVLAPLELLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGE 1843
            :..||..|                    .|:::..:      .|:.||..:|.
  Fly   294 QSQLPVDV--------------------TRLITRMD------EPQVLRLGNVL------------ 320

  Fly  1844 NVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLL 1908
                          :|..|               |....|    .|...|....|:.:|
  Fly   321 --------------MEDGG---------------WYICIA----ENQVGRTVAASYVDL------ 346

  Fly  1909 ELGPYSLS---------LTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQC 1964
                ||.|         .|...:|.|..|...:.....|......:|.....|......|.::.
  Fly   347 ----YSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHS- 406

  Fly  1965 RLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTA--ARGNGAPIALYN 2027
              |.|.......|:| |.|.:..|      :..||....:...| :..||.  .........|||
  Fly   407 --LSGNTVNLACPVY-GKANITWT------KDKKPLNRELGVYV-QKNWTLRFVEATSEDSGLYN 461

  Fly  2028 LEALQA----RSDIRRRRRRRRRNS-------------GGSL-----------EQLPWAEEPVVV 2064
            .:...|    :.|...:...|.|::             .|||           ..:.|  :.||:
  Fly   462 CKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSW--KRVVL 524

  Fly  2065 EDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGW-------GPYSEESE---RVAEPFVS 2119
            ::..||...:.|:..:..::.:..::|........:.||       |.....|.   ||..| :.
  Fly   525 KNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSP-LP 588

  Fly  2120 PEKRGSLVLAIIAPAAIVSSCVLALVLVRKV----QKRRLRAKKLLQQSRPSI--W--------- 2169
            |.:..:|:.|......:.:..::||.|:...    ..||||.:|||:....::  |
  Fly   589 PLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRP 653

  Fly  2170 -----SNLSTLQTQQQLMAVRNR--AFSTT----------LSDADIALLPQINW----SQLKLLR 2213
                 |..|:...|..::.:..:  ..|||          .::.:..|  ..||    .||.|..
  Fly   654 GGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPL--DSNWEIPRQQLSLGS 716

  Fly  2214 FLGSGAFGEVY----EGQLKTEDSEEPQRVAIKSLRK--GASEFAELLQEAQLMSNF-KHENIVC 2271
            .||.||||.|.    ||..::....| ..||:|.:::  ..::.|.|::|.::|... ||.||:.
  Fly   717 ILGEGAFGRVVMAEAEGLPRSPQLAE-TIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIIN 780

  Fly  2272 LVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAG------------LSLSELLAMC 2324
            |:|.|.....:.:|:|:...|:|..:|:..|..:.|....:.|            |...||....
  Fly   781 LLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFA 845

  Fly  2325 IDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLL 2389
            ..:|.|..||.....:|||||.||.||::.       ..:||.||||||||..::||||...|.|
  Fly   846 FQIARGMEYLASRRCIHRDLAARNVLVSDG-------YVMKIADFGLARDIQDTEYYRKNTNGRL 903

  Fly  2390 PVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPY----AARNNFEVLAHVKEGGRLQQPP 2450
            |::||:||||.:..:.:|||||::|||.|||:|.|.|||    :|.   |:.:::..|.|:::|.
  Fly   904 PIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAE---ELYSYLITGQRMEKPA 965

  Fly  2451 MCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATA-DTVVSCSRPEFKV--- 2511
            .|:..:|.::..||..:...||:|.....:...|      .|.||:.. |..:..|.|..:.
  Fly   966 KCSLNIYVVMRQCWHFESCARPTFAELVESFDGI------LQQASSNPNDAYLDLSMPMLETPPS 1024

  Fly  2512 ---RFDGQPLEEHRE 2523
               ..||...|..||
  Fly  1025 SGDEDDGSDTETFRE 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020	11/97 (11%)
		FN3	1993..2111	CDD:238020	25/154 (16%)
		Pkinase_Tyr	2209..2481	CDD:285015	101/294 (34%)
		PTKc_c-ros	2213..2483	CDD:270640	99/292 (34%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653	27/148 (18%)
		IGc2	157..215	CDD:197706	19/110 (17%)
		IG	247..336	CDD:214652	26/172 (15%)
		Ig	258..340	CDD:143165	26/165 (16%)
		I-set	394..479	CDD:254352	19/95 (20%)
		IGc2	408..469	CDD:197706	15/68 (22%)
		IG_like	492..583	CDD:214653	14/92 (15%)
		Ig	507..583	CDD:299845	11/77 (14%)
		PKc_like	700..1000	CDD:304357	106/318 (33%)
		TyrKc	712..996	CDD:197581	101/294 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455224
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940