DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sev and INSR

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_000199.2 Gene:INSR / 3643 HGNCID:6091 Length:1382 Species:Homo sapiens


Alignment Length:1141 Identity:282/1141 - (24%)
Similarity:436/1141 - (38%) Gaps:323/1141 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1580 LEPGSETLNLVDNQGKLCVYDVARQL--CTASALRAQLNLLGEDSIAGQLAQD-------SGYL- 1634
            |.|..:..:|::.:..:.....|::|  ||.......:|:.|.:::|.:|..:       |||| 
Human   332 LGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLK 396

  Fly  1635 ----YAVKNWS-------IRA----------YGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKN 1678
                ||:.:.|       ||.          |....|.|....:.....:.:.|...:..|.||.
Human   397 IRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKL 461

  Fly  1679 CL---------------------LLPSSGGSLLKATDCEEQRCLLHLPMITASEDC------PLP 1716
            ||                     .|.::|..    ..||.:  ||....|..|.|.      |..
Human   462 CLSEIHKMEEVSGTKGRQERNDIALKTNGDQ----ASCENE--LLKFSYIRTSFDKILLRWEPYW 520

  Fly  1717 IPGVR-------------YQLNLT----------------------LAKEPGSEEHD----HGME 1742
            .|..|             || |:|                      .:.:|.|:.|.    .|::
Human   521 PPDFRDLLGFMLFYKEAPYQ-NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLK 584

  Fly  1743 PLGQWLLGAGESLNLTDLLPFTRYRVSGILSS--FYQKKLALPTLVLAPLELLTASATPSPPRNF 1805
            |..|:.:.....:..:|     ..|..|..|.  :.|.....|::.|.|:.:..:|:        
Human   585 PWTQYAIFVKTLVTFSD-----ERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSS-------- 636

  Fly  1806 SVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQD-----------RREWEAHERRLE 1859
                    ::.:.|.||........:|.:.|:::.:...:.:           .|.| :.....|
Human   637 --------QIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTW-SPPFESE 692

  Fly  1860 TAGTHRLTGIKPGSGYSLWVQAHATP-TKSNSSERLHVRSFAELPE--LQLLELGPYSLSLTWAG 1921
            .:..|..:..:..:|     :..:.| |.|...:.|...||.:..|  |..:...|...| :..|
Human   693 DSQKHNQSEYEDSAG-----ECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTS-SGTG 751

  Fly  1922 TPDP--------LGSL-----------------QLECRSSAEQLR--RNVAGNHTKMVVEPLQPR 1959
            ..||        ||.:                 .....:|.|:.|  ..|. |...:|:..|:..
Human   752 AEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVV-NKESLVISGLRHF 815

  Fly  1960 TRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVF-----RVTWTAARGN 2019
            |.|:..|   .|.....|....:...|.:....|.......:..:..|:|     .:.|...:..
Human   816 TGYRIEL---QACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEP 877

  Fly  2020 GAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNT-----TELSC 2079
            ...|.||         ::..||                      ..|:.|..|.:     .|..|
Human   878 NGLIVLY---------EVSYRR----------------------YGDEELHLCVSRKHFALERGC 911

  Fly  2080 IVKSLHSSRLLLFRVRARSLEHGWGPYSEES-----------ERVAEPFVSPEKRGSLVLAIIAP 2133
            .::.|......: |:||.||. |.|.::|.:           ..:|:..:.|      ::.:...
Human   912 RLRGLSPGNYSV-RIRATSLA-GNGSWTEPTYFYVTDYLDVPSNIAKIIIGP------LIFVFLF 968

  Fly  2134 AAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADI 2198
            :.::.|..|.|      :||        |...|           ...|.|..|..:   ||.:|:
Human   969 SVVIGSIYLFL------RKR--------QPDGP-----------LGPLYASSNPEY---LSASDV 1005

  Fly  2199 ----ALLP---QINWSQLKLLRFLGSGAFGEVYEGQLK-TEDSEEPQRVAIKSLRKGAS--EFAE 2253
                ..:|   :::..::.|||.||.|:||.||||..: ....|...|||:|::.:.||  |..|
Human  1006 FPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIE 1070

  Fly  2254 LLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQ---EPQPTAGL 2315
            .|.||.:|..|...::|.|:|:....:...::||.|..|||.||||:.|..:..   .|.||   
Human  1071 FLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPT--- 1132

  Fly  2316 SLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDY 2380
             |.|::.|..::|:|.:||....|||||||.|||:|....       ||||||||:.||||::||
Human  1133 -LQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDF-------TVKIGDFGMTRDIYETDY 1189

  Fly  2381 YRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGR 2445
            |||.|:||||||||:||||.||:|||.||:|:|||:.|||.:|.:|||...:|.:||..|.:||.
Human  1190 YRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGY 1254

  Fly  2446 LQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEF- 2509
            |.||..|.|::..|:.:||:.:|..||:|....|.|   ..||                 .|.| 
Human  1255 LDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL---KDDL-----------------HPSFP 1299

  Fly  2510 KVRFDGQPLEEHREHNERPEDENL-----TLREVPL 2540
            :|.|      .|.|.|:.||.|.|     .:..|||
Human  1300 EVSF------FHSEENKAPESEELEMEFEDMENVPL 1329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470
FN3 826..921 CDD:238020
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
FN3 1799..1897 CDD:238020 14/109 (13%)
FN3 1993..2111 CDD:238020 23/138 (17%)
Pkinase_Tyr 2209..2481 CDD:285015 128/277 (46%)
PTKc_c-ros 2213..2483 CDD:270640 127/275 (46%)
INSRNP_000199.2 Recep_L_domain 52..164 CDD:279382
Furin-like 179..337 CDD:279142 2/4 (50%)
FU 234..281 CDD:238021
Recep_L_domain 359..472 CDD:279382 24/112 (21%)
FN3 622..>665 CDD:238020 9/58 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..708 3/26 (12%)
Insulin-binding 733..741 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 746..766 5/20 (25%)
FN3 867..944 CDD:238020 20/109 (18%)
PTKc_InsR 1016..1303 CDD:133192 134/317 (42%)
Pkinase_Tyr 1023..1290 CDD:285015 128/277 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1360..1382
PIK3R1-binding 1361..1364
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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