Protein Alignment sev and Fes

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_001101958.1
• Gene: Fes / 361597
• RGDID: 1564385
• Length: 822
• Species: Rattus norvegicus
• Alignment Length: 1078
• Identity: 254/1078 - (23%)
• Similarity: 399/1078 - (37%)
• Gaps: 362/1078 - (33%)

  Fly  1503 DLCNFEG------------KILQGERVWSTPRGRLLKDLVALPQAQSLIWLEYEQGSPRNGSLRG 1555
            :||:.:|            ::|:|.|.|...|.:..::...|....||    .:.|        |
  Rat     6 ELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSL----QDSG--------G 58

  Fly  1556 RNLTDGSE----LEWATVQPLIRLHAGSLEPGSETLNLVDNQGKLCVYDVARQLCTASALRAQLN 1616
            ::.:.|.:    ..||.:.             |:|.||                  :..||..
  Rat    59 QSWSSGPDSPVSQSWAEIT-------------SQTENL------------------SRVLRQH-- 90

  Fly  1617 LLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLE--------YTVELEPEEVRLLQAHNYQA 1673
              .||..:|.|::.| .|...:....:.|..:.|||:        ..:|....:.|.|...:.||
  Rat    91 --AEDLNSGPLSKLS-VLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKSQYRTLTRDSAQA 152

  Fly  1674 ---YPPKNCLLLPSSGGSLLKATDCEEQRCLLHLPMITASEDCPLPIPGVRYQLNLTLAKEPGSE 1735
               |          ...|..|..|..:.:.:..|..:.|..:        ||.|.:..|:.  ..
  Rat   153 RRKY----------QEASKDKDRDKAKDKYVRSLWKLFAHHN--------RYVLGVRAAQL--HH 197

  Fly  1736 EHDHGMEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLV---LAPL--ELLTA 1795
            :|.|      |::| .|...:|.||    ...::|||....|:.|.:.:||   :|.:  ||..|
  Rat   198 QHYH------QFML-PGLLQSLQDL----HEEMAGILKDILQEYLEISSLVQDDVASIHRELAAA 251

  Fly  1796 SATPSPPRNFSVRVLSPRELEVSWL------------PPEQLRSESVYYTLHWQQELDGENVQDR 1848
            :|...|              |..:|            ||      .|.:.:...:|  ||.
  Rat   252 AARIQP--------------EFEYLGFLRQYGSAPDVPP------CVTFDVSLLEE--GEQ---- 290

  Fly  1849 REWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPY 1913
                                ::||                               :|||.||...
  Rat   291 --------------------LEPG-------------------------------DLQLNELTLE 304

  Fly  1914 SLSLTWAGTPDPLGSLQLECRSSAE---QLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPG 1975
            |:..|.....|.|.....|..|..|   ||:|.:     :...:...||.|.|   ||
  Rat   305 SVQHTLTSVTDELAVATKEVLSRQEMVSQLQREL-----QCEEQNTHPRERVQ---LL------- 354

  Fly  1976 APLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRR 2040
                                 ||.|   :.:|..:         |..:||.|.:.|||:.::.:.
  Rat   355 ---------------------GKRQ---VLQEAMQ---------GLQVALCNQDKLQAQQELLQS 386

  Fly  2041 RRRRRRNSGGSLEQLPWAEEPVV--VED---------QWLDFCNTTELSCIVKSLHSSRLLLFR- 2093
            :          :|||...|.|.|  ::|         |..|...|..|. |:||..|.   :||
  Rat   387 K----------MEQLGTGEPPAVPLLQDDRHSTSSTEQERDGGRTPTLE-IIKSHFSG---IFRP 437

  Fly  2094 -----------------VRARSLEHGWGPYSEESERVAE--PFVSPEKRG--SLVLAIIAPAAIV 2137
                             :..:...||..|.:|.:|.:..  .|:..|.:|  ..||:::...
  Rat   438 KFSIPPPLQLVPEVQKPLHEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVLWDG--- 499

  Fly  2138 SSCVLALVLVRKVQKRRLRAKKLLQQSR----------PSIWSNLSTLQTQQQLMAVRNRAFSTT 2192
                         |.|..    ::|.|.          |||...::.|.:.||.:..::   ...
  Rat   500 -------------QPRHF----IIQSSDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKS---GVV 544

  Fly  2193 LSDADIALLPQINW----SQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASE--F 2251
            |..|    :|:..|    ..|.|...:|.|.||||:.|:|:.:::.    ||:||.|:....  .
  Rat   545 LFRA----VPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTP----VAVKSCRETLPPDLK 601

  Fly  2252 AELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLS 2316
            |:.||||:::..:.|.|||.|:|:|...:.|.::||.::.||.|::||...|.          |.
  Rat   602 AKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGAR----------LR 656

  Fly  2317 LSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYY 2381
            :..||.|..|.|.|..|||....:|||||.|||||||       :..:||.|||::|:.....|.
  Rat   657 VKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTE-------KNVLKISDFGMSREEADGIYA 714

  Fly  2382 RKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRL 2446
            ...|...:||:|.:||:|..|.::::||||:||:|.||..:||..||....|.:....|::|.||
  Rat   715 ASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRL 779

  Fly  2447 QQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAI 2484
            ..|.:|.:.::.|:..||..:|.:||||......|.:|
  Rat   780 PCPELCPDAVFRLMEQCWAYEPGQRPSFSTICQELQSI 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	11/102 (11%)
		FN3	1993..2111	CDD:238020	32/146 (22%)
		PTKc_c-ros	2213..2483	CDD:270640	100/271 (37%)
Fes	NP_001101958.1	F-BAR_Fes	7..239	CDD:153369	62/310 (20%)
		SH2_Fps_family	453..537	CDD:198224	20/103 (19%)
		Protein Kinases, catalytic domain	564..815	CDD:473864	99/271 (37%)