DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and fgfr2

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:XP_068081038.1 Gene:fgfr2 / 352940 ZFINID:ZDB-GENE-030323-1 Length:840 Species:Danio rerio


Alignment Length:929 Identity:236/929 - (25%)
Similarity:366/929 - (39%) Gaps:230/929 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1740 GMEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATPSPPRN 1804
            ||...| |||||        ||..|...||          :|.|:|   .::|:..||...||..
Zfish    23 GMFARG-WLLGA--------LLLMTLATVS----------VARPSL---KIDLVNTSAPEEPPTK 65

  Fly  1805 --------FSVRVLSPREL-----------EVSWL-PPEQLRSES-VYYTLHWQQELDGE----- 1843
                    |||.   |.||           :|.|. ....||.:: ...|..|.|..|..     
Zfish    66 NQNCVPVLFSVH---PGELLKLKCPLSGADDVVWTKDSSSLRPDNRTLVTRDWLQISDATPKDSG 127

  Fly  1844 -------------------NVQD---RREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPT 1886
                               ||.|   ..:.|....|.:..|         ..|..:.:.....|.
Zfish   128 LYSCSATGSRDCDVFSFIVNVTDAISSGDDEDDTERSDDVG---------ADGEQMRLPYWTFPE 183

  Fly  1887 KSNSSERLHVRSFAELPELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKM 1951
            |  ..::||....|...:.:....|.....:.|.....|   .:.|.|....::|.    .|..:
Zfish   184 K--MEKKLHAVPAANTVKFRCAAAGNPKPKMRWLKNAKP---FRQEDRMGGYKVRL----QHWTL 239

  Fly  1952 VVEPLQP--RTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWT 2014
            ::|.:.|  :..|.|.:...|    |:..:..|.:|.|.   :|.:|       |.:.......|
Zfish   240 IMESVVPSDKGNYTCLVENQY----GSINHTYTLDVVER---SPHRP-------ILQAGLPANVT 290

  Fly  2015 AARGNGAPIA--LYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAE----EPVVVEDQWLD--- 2070
            ...|..|...  :|:    .|:..|:..:...:..|....:.||:..    ..|...|:.::   
Zfish   291 VQVGQDAKFVCKVYS----DAQPHIQWLQHYTKNGSRYGPDGLPYVRVLKTAGVNTTDKEIEVLY 351

  Fly  2071 -----FCNTTELSCIVK-----SLHSSRLLLFRVRARSLEHGWGP-YSEESERVAEPFVSPEKRG 2124
                 |.:..|.:|:..     |.|::.|.:.......:|..:.| |.|                
Zfish   352 LPNVTFEDAGEYTCLAGNSIGISYHTAWLTVHPAETNPIETDYPPDYVE---------------- 400

  Fly  2125 SLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIW-------------------S 2170
               :||......:.:|::.:|:|.::   |..|||....|:|::.                   |
Zfish   401 ---IAIYCIGVFLIACMVVIVVVCRM---RTSAKKPDFSSQPAVHKLTKQIPLRRQVTVSSDSSS 459

  Fly  2171 NLSTLQTQQQLMAVRNRAFSTTLSDADIALLPQINWSQLKLL--RFLGSGAFGEVYEGQLKTEDS 2233
            ::|:.....::...|:.|....:.:.|:...|:..:|:.||.  :.||.|.||:|...:....|.
Zfish   460 SMSSSTPLVRITTRRSSAHDDPIPEYDLPEDPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDK 524

  Fly  2234 EEPQR---VAIKSLRKGASE--FAELLQEAQLMSNF-KHENIVCLVGICFDTESISLIMEHMEAG 2292
            ::|:.   ||:|.|:..|:|  .::|:.|.::|... :|:||:.|:|.|.....:.:|:|:...|
Zfish   525 DKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGRHKNIINLLGACTQDGPLYVIVEYASKG 589

  Fly  2293 DLLSYLRAAR----------ATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACR 2347
            :|..||||.|          |..:.||     |:..:|::....||.|..||.....:|||||.|
Zfish   590 NLREYLRARRPPGMEYSYDIARVSDEP-----LTFKDLVSCTYQVARGMEYLASQKCIHRDLAAR 649

  Fly  2348 NCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWA 2412
            |.|||||       ..:||.|||||||::..|||:|...|.|||:||:||:|.|.::|.|||||:
Zfish   650 NVLVTES-------NVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 707

  Fly  2413 FGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRC 2477
            ||||.|||.|||..||......|:...:|||.|:.:|..||.:||.::..||......||:|::.
Zfish   708 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMKDCWHAISSHRPTFKQL 772

  Fly  2478 YNTLHAIST--------DLRR--TQMASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPEDEN 2532
            ...|..|.|        ||..  .|.:.:..||..|||..:..| |...||.:.           
Zfish   773 VEDLDRILTLATNEEYLDLCAPVEQYSPSFPDTRSSCSSGDDSV-FSHDPLADE----------- 825

  Fly  2533 LTLREVPLKDKQLYANEGV 2551
                  |...|..:.|.|:
Zfish   826 ------PCLPKYQHINGGI 838

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996 25/138 (18%)
FN3 1993..2111 CDD:238020 24/137 (18%)
PTKc_c-ros 2213..2483 CDD:270640 111/285 (39%)
fgfr2XP_068081038.1 Ig 56..148 CDD:472250 18/94 (19%)
Ig strand B 82..86 CDD:409353 0/3 (0%)
Ig strand E 114..118 CDD:409353 1/3 (33%)
Ig strand F 128..133 CDD:409353 0/4 (0%)
Ig strand G 141..144 CDD:409353 0/2 (0%)
IgI_2_FGFR 177..271 CDD:409443 19/106 (18%)
Ig strand A 177..180 CDD:409443 0/2 (0%)
Ig strand A' 188..193 CDD:409443 2/4 (50%)
Ig strand B 197..205 CDD:409443 0/7 (0%)
Ig strand C 211..216 CDD:409443 1/4 (25%)
Ig strand C' 219..221 CDD:409443 1/4 (25%)
Ig strand D 230..233 CDD:409443 0/2 (0%)
Ig strand E 237..242 CDD:409443 0/4 (0%)
Ig strand F 251..258 CDD:409443 2/6 (33%)
Ig strand G 261..271 CDD:409443 2/9 (22%)
IgI_3_FGFR2 279..383 CDD:409444 19/114 (17%)
Ig strand A 279..282 CDD:409444 2/9 (22%)
Ig strand A' 286..290 CDD:409444 0/3 (0%)
Ig strand B 298..305 CDD:409444 0/6 (0%)
Ig strand C 309..316 CDD:409444 1/6 (17%)
Ig strand D 331..336 CDD:409444 0/4 (0%)
Ig strand E 348..353 CDD:409444 0/4 (0%)
Ig strand F 361..369 CDD:409444 2/7 (29%)
Ig strand G 372..380 CDD:409444 2/7 (29%)
PTKc_FGFR2 475..787 CDD:270679 119/323 (37%)
Blue background indicates that the domain is not in the aligned region.

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