Protein Alignment sev and IGF1R

DIOPT Version :9

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: XP_016877625.1
• Gene: IGF1R / 3480
• HGNCID: 5465
• Length: 1392
• Species: Homo sapiens
• Alignment Length: 1132
• Identity: 307/1132 - (27%)
• Similarity: 446/1132 - (39%)
• Gaps: 283/1132 - (25%)

  Fly  1527 KDLVALPQAQSLIWLEYEQGSPRNGSLRGRNLTDGSELEWATVQPLIRLHAGSLEPGSETLNLVD 1591
            |.:.::..||.|......:|:......||.|:  .||||  ....||.:..|.::
Human   364 KTIDSVTSAQMLQGCTIFKGNLLINIRRGNNI--ASELE--NFMGLIEVVTGYVK---------- 414

  Fly  1592 NQGKLCVYDVARQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTV 1656
                   ...:..|.:.|.|:....:|||:.:.|..:     .|.:.|          |.|:...
Human   415 -------IRHSHALVSLSFLKNLRLILGEEQLEGNYS-----FYVLDN----------QNLQQLW 457

  Fly  1657 ELEPEEVRLLQAHNYQAYPPKNCL--------LLPSSG----GSLLKATDCEEQRC---LLHLPM 1706
            :.:...:.:.....|.|:.||.|:        :..:.|    |.:....:.|...|   :||...
Human   458 DWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTS 522

  Fly  1707 ITASEDCPL-------PIPGVRYQLNLTL----AKEPGSEEHDHGMEPLGQWLLGAGESLNLTD- 1759
            .|.|::..:       | |..|..::.|:    |......|:| |.:..|      ..|.|:.|
Human   523 TTTSKNRIIITWHRYRP-PDYRDLISFTVYYKEAPFKNVTEYD-GQDACG------SNSWNMVDV 579

  Fly  1760 ----------------LLPFTRYRVSGILSSFYQKKLALPTLVL------APLELL---TASATP 1799
                            |.|:|:|.|       |.|.:.| |:|.      |..|:|   |.::.|
Human   580 DLPPNKDVEPGILLHGLKPWTQYAV-------YVKAVTL-TMVENDHIRGAKSEILYIRTNASVP 636

  Fly  1800 SPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQ-QELDG----------ENVQDRREWEA 1853
            |.|.:......|..:|.|.|.||........||.:.|| |..||          :.:..|:..:.
Human   637 SIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADG 701

  Fly  1854 H---ERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSER------LHVRSFAELPE----- 1904
            .   |...|...|....|.|.........:|.....|..:..|      ||...|...||
Human   702 TIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRD 766

  Fly  1905 -LQLLE--LGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRL 1966
             :|:..  :...|.:.|.|.|.:.....:||......:.|   ..|..:.|:..|:|.|.|:..:
Human   767 VMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESR---VDNKERTVISNLRPFTLYRIDI 828

  Fly  1967 LLGYAATPGAPLYHGTAEVYETLGDAPSQ---------------PGKPQLEHIAEEVFRVTWTAA 2016
                         |......|.||.:.|.               ||....|...|....:.|...
Human   829 -------------HSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEP 880

  Fly  2017 RGNGAPIALYNLEALQARSDIRR--RRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSC 2079
            ......|.:|.::......|.|.  .|:..|:..|..|.:|                 |....:.
Human   881 ENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRL-----------------NPGNYTA 928

  Fly  2080 IVKSLHSSRLLLFRVRARSLEHGWGPYSE------ESERVAEPFVSPEKRGSLVLAI-IAPAAIV 2137
                         |::|.||. |.|.:::      :::...|.|:      .|::|: :|...||
Human   929 -------------RIQATSLS-GNGSWTDPVFFYVQAKTGYENFI------HLIIALPVAVLLIV 973

  Fly  2138 SSCVLAL-VLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALL 2201
            ...|:.| |..||....||....|.....|..:                        |.||: .:
Human   974 GGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYF------------------------SAADV-YV 1013

  Fly  2202 PQINW----SQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQ-RVAIKSLRKGAS--EFAELLQEAQ 2259
            |. .|    .::.:.|.||.|:||.||||..|....:||: |||||::.:.||  |..|.|.||.
Human  1014 PD-EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEAS 1077

  Fly  2260 LMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMC 2324
            :|..|...::|.|:|:....:...:|||.|..|||.||||:.|......| ..|..|||:::.|.
Human  1078 VMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNP-VLAPPSLSKMIQMA 1141

  Fly  2325 IDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLL 2389
            .::|:|.:||....|||||||.|||:|.|..       ||||||||:.||||::|||||.|:|||
Human  1142 GEIADGMAYLNANKFVHRDLAARNCMVAEDF-------TVKIGDFGMTRDIYETDYYRKGGKGLL 1199

  Fly  2390 PVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTE 2454
            ||||||||||.||:|||.||||:|||:.|||.||.:|||...:|.:||..|.|||.|.:|..|.:
Human  1200 PVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPD 1264

  Fly  2455 KLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEFK-VRFDGQPL 2518
            .|:.|:.:||:.:|..||||      |..||              ::.....|.|: |.|
Human  1265 MLFELMRMCWQYNPKMRPSF------LEIIS--------------SIKEEMEPGFREVSF----- 1304

  Fly  2519 EEHREHNERPEDENLTL-----REVPL 2540
             .:.|.|:.||.|.|.|     ..|||
Human  1305 -YYSEENKLPEPEELDLEPENMESVPL 1330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020	27/117 (23%)
		FN3	1993..2111	CDD:238020	22/140 (16%)
		Pkinase_Tyr	2209..2481	CDD:285015	134/274 (49%)
		PTKc_c-ros	2213..2483	CDD:270640	135/272 (50%)
IGF1R	XP_016877625.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010