DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sev and Ror

DIOPT Version :9

Sequence 1:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster
Sequence 2:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	209/744 - (28%)
Similarity:	310/744 - (41%)	Gaps:	180/744 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1783 PTLVLAPLELLTASA----TPSPPRNFSVRVLSPRELEVSWLP----PEQLRSESVYYTLHWQQE 1839
            |.|.:..||....:|    ..|...|.:.|:.:...|..|.:|    ||  |:..:|:.......
  Fly    62 PNLTMNDLEERLKAAYGVIKESKDMNANCRMYALPSLCFSSMPICRTPE--RTNLLYFANVATNA 124

  Fly  1840 LDGENVQDRREWEAHERRLETAGTHRLTGIKPGSG-----YSLWVQAHATPTKSNSSERLHVRSF 1899
            ...:||..||      :|.::.....::..|..|.     :|..:.:...||:.:.:.:...|..
  Fly   125 KQLKNVSIRR------KRTKSKDIKNISIFKKKSTIYEDVFSTDISSKYPPTRESENLKRICREE 183

  Fly  1900 AELPELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMV-VEPLQPRTRYQ 1963
            .||.|.:|.:                        :..|...|..|.|    || ||..|...:::
  Fly   184 CELLENELCQ------------------------KEYAIAKRHPVIG----MVGVEDCQKLPQHK 220

  Fly  1964 CRLLLGYAAT---------PGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGN 2019
            ..|.||....         .....|.|.|.|        |..|||.|        |.:|
  Fly   221 DCLSLGITIEVDKTENCYWEDGSTYRGVANV--------SASGKPCL--------RWSW------ 263

  Fly  2020 GAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSL 2084
                      .::..||......:....:.||:|..||                     |.|
  Fly   264 ----------LMKEISDFPELIGQNYCRNPGSVENSPW---------------------CFV--- 294

  Fly  2085 HSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAA---IVSSCVLALVL 2146
            .|||                      ||:.|....|:....:.:||:...|   ::...:.|::|
  Fly   295 DSSR----------------------ERIIELCDIPKCADKIWIAIVGTTAAIILIFIIIFAIIL 337

  Fly  2147 VRKVQKRRLRAKKLLQQSRPSIWSNL---STLQTQQQLMAVRNRAFSTTLSDADIAL-------- 2200
            .::........:.:...:.||...|:   |.|...|.    ..|.....||| .:||
  Fly   338 FKRRTIMHYGMRNIHNINTPSADKNIYGNSQLNNAQD----AGRGNLGNLSD-HVALNSKLIERN 397

  Fly  2201 -LPQINWSQLKLLRF---LGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGAS--EFAELLQEAQ 2259
             |.:||...|:.:.|   ||.||||:||:||| .:.::....||||:|::.||  ...:..:|.:
  Fly   398 TLLRINHFTLQDVEFLEELGEGAFGKVYKGQL-LQPNKTTITVAIKALKENASVKTQQDFKREIE 461

  Fly  2260 LMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSEL--LA 2322
            |:|:.||:||||::|:..:.|...::.|:|..|||..:|.:        ..||.|.|||:|  |.
  Fly   462 LISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLIS--------NSPTEGKSLSQLEFLQ 518

  Fly  2323 MCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEG 2387
            :.:.::.|..||...|:||||||.|||||.|..       .|||.||||:||||.|||||.:.:.
  Fly   519 IALQISEGMQYLSAHHYVHRDLAARNCLVNEGL-------VVKISDFGLSRDIYSSDYYRVQSKS 576

  Fly  2388 LLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMC 2452
            |||||||..||::.|.|||:||||:|||:.|||.:.|.|||...:|.||:..::....|..|..|
  Fly   577 LLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENC 641

  Fly  2453 TEKLYSLLLLCWRTDPWERPSFRRCYNTL 2481
            ...:|||::.||.....:||:|....|.|
  Fly   642 PTAVYSLMIECWHEQSVKRPTFTDISNRL 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020	20/106 (19%)
		FN3	1993..2111	CDD:238020	19/117 (16%)
		Pkinase_Tyr	2209..2481	CDD:285015	119/278 (43%)
		PTKc_c-ros	2213..2483	CDD:270640	119/276 (43%)
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	42/201 (21%)
		KR	235..312	CDD:214527	27/154 (18%)
		PTKc_Ror	404..673	CDD:270642	120/283 (42%)
		Pkinase_Tyr	410..670	CDD:285015	118/275 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455278
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940